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The tumor microenvironment (TME) is a spatially heterogeneous ecosystem where cellular interactions shape tumor progression and response to therapy. Multiplexed imaging technologies enable high-resolution spatial characterization of the…

Applications · Statistics 2025-04-04 Joel Eliason , Arvind Rao , Timothy L Frankel , Michele Peruzzi

In this study we investigate the Percolation Hypothesis for Multiple Sclerosis Progression. The methodology relies on cross-reference analysis centered around a question: What is the evidence for a Percolation/phase-transition hypothesis in…

Disordered Systems and Neural Networks · Physics 2026-02-10 Nikola Mirkov , Dušan S. Radivojević , Slobodan Maletić

Atherosclerosis is a chronic inflammatory disease of the artery wall. The early stages of atherosclerosis are driven by interactions between lipids and monocyte-derived-macrophages (MDMs). The mechanisms that govern the spatial distribution…

Cell Behavior · Quantitative Biology 2025-02-10 Keith L. Chambers , Mary R. Myerscough , Michael G. Watson , Helen M. Byrne

Wrinkling is the phenomenon of out-of-plane deformation patterns in thin walled structures, as a result of a local compressive (internal) loads in combination with a large membrane stiffness and a small but non-zero bending stiffness.…

Numerical Analysis · Mathematics 2025-03-20 H. M. Verhelst , M. Möller , J. H. Den Besten

In this paper the Turing pattern formation mechanism of a two component reaction-diffusion system modeling the Schnakenberg chemical reaction coupled to linear cross-diffusion terms is studied. The linear cross-diffusion terms favors the…

Pattern Formation and Solitons · Physics 2017-05-08 G. Gambino , S. Lupo , M. Sammartino

Motivated by numerical simulations showing the emergence of either periodic or irregular patterns, we explore a mechanism of pattern formation arising in the processes described by a system of a single reaction-diffusion equation coupled…

Analysis of PDEs · Mathematics 2015-03-19 Anna Marciniak-Czochra , Grzegorz Karch , Kanako Suzuki

We investigate a recently proposed cross-diffusion system modelling the growth of gliobastoma taking into account size exclusion both in the migration and proliferation process. In addition to degenerate nonlinear cross-diffusion the model…

Analysis of PDEs · Mathematics 2017-10-12 Martin Burger , Patricia Friele , Jan-Frederik Pietschmann

Precision medicine involves answering counterfactual questions such as "Would this patient respond better to treatment A or treatment B?" These types of questions are causal in nature and require the tools of causal inference to be…

Computer Vision and Pattern Recognition · Computer Science 2021-07-15 Jacob C. Reinhold , Aaron Carass , Jerry L. Prince

Pattern formation from homogeneity is well-studied, but less is known concerning symmetry-breaking instabilities in heterogeneous media. It is nontrivial to separate observed spatial patterning due to inherent spatial heterogeneity from…

Pattern Formation and Solitons · Physics 2019-12-10 Andrew L. Krause , Václav Klika , Thomas E. Woolley , Eamonn A. Gaffney

While the ultrastructure of the myelin has been considered to be a quasi-crystalline stable system, nowadays its multiscale complex dynamics appears to play a key role for its functionality, degeneration and repair processes following…

Quantitative Methods · Quantitative Biology 2017-09-20 Michael Di Gioacchino , Gaetano Campi , Nicola Poccia , Antonio Bianconi

We give a comprehensive study of the analytic properties and long-time behavior of solutions of a reaction-diffusion system in a bounded domain in the case where the nonlinearity satisfies the standard monotonicity assumption. We pay the…

Analysis of PDEs · Mathematics 2020-06-11 Anna Kostianko , Chunyou Sun , Sergey Zelik

We present a theoretical study on pattern formation occurring in miscible fluids reacting by a second-order reaction $A + B \to S$ in a vertical Hele-Shaw cell under constant gravity. We have recently reported that concentration-dependent…

Fluid Dynamics · Physics 2019-09-25 Dmitry Bratsun

We revisit a classical continuum model for the diffusion of multiple species with size-exclusion constraint, which leads to a degenerate nonlinear cross-diffusion system. The purpose of this article is twofold: first, it aims at a…

Analysis of PDEs · Mathematics 2022-08-04 Katharina Hopf , Martin Burger

Injuries to articular cartilage result in the development of lesions that form on the surface of the cartilage. Such lesions are associated with articular cartilage degeneration and osteoarthritis. The typical injury response often causes…

Tissues and Organs · Quantitative Biology 2011-09-08 Jason M. Graham , Bruce P. Ayati , Lei Ding , Prem S. Ramakrishnan , James A. Martin

In this paper, we investigate a mathematical model describing the interactions between effector cells (E), cancer cells (T), and the IL-2 compound (IL). The model considered here is a generalization, taking into account some cross-diffusion…

Dynamical Systems · Mathematics 2025-12-02 C. F. Munafò , S. Bonfiglio , P. Rogolino

Recent advances in denoising diffusion probabilistic models have shown great success in image synthesis tasks. While there are already works exploring the potential of this powerful tool in image semantic segmentation, its application in…

Computer Vision and Pattern Recognition · Computer Science 2023-09-19 Xinrong Hu , Yu-Jen Chen , Tsung-Yi Ho , Yiyu Shi

Plastic deformation of crystalline and amorphous matter often involves intermittent local strain burst events. To understand the physical background of the phenomenon a minimal stochastic mesoscopic model was introduced, where…

Materials Science · Physics 2017-02-15 Péter Dusán Ispánovity , Dániel Tüzes , Péter Szabó , Michael Zaiser , István Groma

We study a nonlocal adhesion model for two interacting tumor cell phenotypes, combining diffusion, pairwise interactions, and random phenotypic switching. The system admits a microscopic diffusion--jump particle description whose mean-field…

Analysis of PDEs · Mathematics 2026-03-16 Myeongju Chae , Young-Pil Choi

Reaction-diffusion processes across layered media arise in several scientific domains such as pattern-forming E. coli on agar substrates, epidermal-mesenchymal coupling in development, and symmetry-breaking in cell polarisation. We develop…

Pattern Formation and Solitons · Physics 2020-09-18 Andrew L. Krause , Václav Klika , Jacob Halatek , Paul K. Grant , Thomas E. Woolley , Neil Dalchau , Eamonn A. Gaffney

The matter distribution of the Universe can be mapped through the weak gravitational lensing (WL) effect: small distortions of the shapes of distant galaxies, which reflects the inhomogeneity of the cosmic density field. The most dominant…

Cosmology and Nongalactic Astrophysics · Physics 2025-11-21 Shohei D. Aoyama , Ken Osato , Masato Shirasaki
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