Percolation and Threshold-like Behavior in Multiple Sclerosis Progression
Disordered Systems and Neural Networks
2026-02-10 v1
Abstract
In this study we investigate the Percolation Hypothesis for Multiple Sclerosis Progression. The methodology relies on cross-reference analysis centered around a question: What is the evidence for a Percolation/phase-transition hypothesis in Multiple Sclerosis (MS), especially the idea that the RRMS dynamic balance can abruptly break akin to crossing a percolation threshold into SPMS? We identify theoretical models invoking percolation/critical thresholds, network/connectome studies assessing percolation robustness or threshold-like behavior, clinical markers showing thresholds or early-warning signals, and counter-evidence arguing for gradual/continuum transitions.
Cite
@article{arxiv.2602.08576,
title = {Percolation and Threshold-like Behavior in Multiple Sclerosis Progression},
author = {Nikola Mirkov and Dušan S. Radivojević and Slobodan Maletić},
journal= {arXiv preprint arXiv:2602.08576},
year = {2026}
}