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Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

In many histopathology tasks, sample classification depends on morphological details in tissue or single cells that are only visible at the highest magnification. For a pathologist, this implies tedious zooming in and out, while for a…

Computer Vision and Pattern Recognition · Computer Science 2023-03-03 Ario Sadafi , Nassir Navab , Carsten Marr

Image classification is central to the big data revolution in medicine. Improved information processing methods for diagnosis and classification of digital medical images have shown to be successful via deep learning approaches. As this…

Image and Video Processing · Electrical Eng. & Systems 2020-06-25 Kamran Kowsari , Rasoul Sali , Lubaina Ehsan , William Adorno , Asad Ali , Sean Moore , Beatrice Amadi , Paul Kelly , Sana Syed , Donald Brown

In digital histopathology, entire neoplasm segmentation on Whole Slide Image (WSI) of Hepatocellular Carcinoma (HCC) plays an important role, especially as a preprocessing filter to automatically exclude healthy tissue, in histological…

Image and Video Processing · Electrical Eng. & Systems 2023-07-13 Zhuxian Guo , Qitong Wang , Henning Müller , Themis Palpanas , Nicolas Loménie , Camille Kurtz

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

The current study of cell architecture of inflammation in histopathology images commonly performed for diagnosis and research purposes excludes a lot of information available on the biopsy slide. In autoimmune diseases, major outstanding…

Image and Video Processing · Electrical Eng. & Systems 2022-10-25 Pranav Singh , Jacopo Cirrone

This paper presents an autoencoder-based neural network architecture to compress histopathological images while retaining the denser and more meaningful representation of the original images. Current research into improving compression…

Image and Video Processing · Electrical Eng. & Systems 2023-05-15 Agnes Barsi , Suvendu Chandan Nayak , Sasmita Parida , Raj Mani Shukla

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

A large number of different lesions and pathologies can affect the human digestive system, resulting in life-threatening situations. Early detection plays a relevant role in the successful treatment and the increase of current survival…

Image and Video Processing · Electrical Eng. & Systems 2021-11-18 Adrian Galdran , Gustavo Carneiro , Miguel A. González Ballester

The whole slide histopathology images (WSIs) play a critical role in gastric cancer diagnosis. However, due to the large scale of WSIs and various sizes of the abnormal area, how to select informative regions and analyze them are quite…

Computer Vision and Pattern Recognition · Computer Science 2020-10-14 Shujun Wang , Yaxi Zhu , Lequan Yu , Hao Chen , Huangjing Lin , Xiangbo Wan , Xinjuan Fan , Pheng-Ann Hen

A large amount of research on Convolutional Neural Networks has focused on flat Classification in the multi-class domain. In the real world, many problems are naturally expressed as problems of hierarchical classification, in which the…

Computer Vision and Pattern Recognition · Computer Science 2020-05-19 Riccardo La Grassa , Ignazio Gallo , Nicola Landro

High-throughput "pathomic" analysis of Whole Slide Images (WSIs) offers new opportunities to study tissue characteristics and for biomarker discovery. However, the clinical relevance of the tissue characteristics at the micro- and…

Computer Vision and Pattern Recognition · Computer Science 2025-12-24 Yuechen Yang , Junlin Guo , Yanfan Zhu , Jialin Yue , Junchao Zhu , Yu Wang , Shilin Zhao , Haichun Yang , Xingyi Guo , Jovan Tanevski , Laura Barisoni , Avi Z. Rosenberg , Yuankai Huo

Deep learning methods have emerged as powerful tools for analyzing histopathological images, but current methods are often specialized for specific domains and software environments, and few open-source options exist for deploying models in…

The popular use of histopathology images, such as hematoxylin and eosin (H&E), has proven to be useful in detecting tumors. However, moving such cancer cases forward for treatment requires accurate on the amount of the human epidermal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Olaide N. Oyelade , Oliver Hoxey , Yulia Humrye

Advancement in digital pathology and artificial intelligence has enabled deep learning-based computer vision techniques for automated disease diagnosis and prognosis. However, WSIs present unique computational and algorithmic challenges.…

Computer Vision and Pattern Recognition · Computer Science 2021-06-15 Yash Sharma , Lubaina Ehsan , Sana Syed , Donald E. Brown

In histopathological image analysis, feature extraction for classification is a challenging task due to the diversity of histology features suitable for each problem as well as presence of rich geometrical structures. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2016-03-30 Tiep Huu Vu , Hojjat Seyed Mousavi , Vishal Monga , Arvind UK Rao , Ganesh Rao

Due to its superior efficiency in utilizing annotations and addressing gigapixel-sized images, multiple instance learning (MIL) has shown great promise as a framework for whole slide image (WSI) classification in digital pathology…

Quantitative Methods · Quantitative Biology 2023-07-14 Qiehe Sun , Jiawen Li , Jin Xu , Junru Cheng , Tian Guan , Yonghong He

Developing deep learning models to analyze histology images has been computationally challenging, as the massive size of the images causes excessive strain on all parts of the computing pipeline. This paper proposes a novel deep…

Image and Video Processing · Electrical Eng. & Systems 2021-01-13 Joseph DiPalma , Arief A. Suriawinata , Laura J. Tafe , Lorenzo Torresani , Saeed Hassanpour

Timely cancer reporting data are required in order to understand the impact of cancer, inform public health resource planning and implement cancer policy especially in Sub Saharan Africa where the reporting lag is behind world averages.…

Machine Learning · Computer Science 2020-09-02 Waheeda Saib , Tapiwa Chiwewe , Elvira Singh

This work addresses how to efficiently classify challenging histopathology images, such as gigapixel whole-slide images for cancer diagnostics with image-level annotation. We use images with annotated tumor regions to identify a set of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Mohammad Iqbal Nouyed , Mary-Anne Hartley , Gianfranco Doretto , Donald A. Adjeroh