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Understanding the biological mechanisms of disease is crucial for medicine, and in particular, for drug discovery. AI-powered analysis of genome-scale biological data holds great potential in this regard. The increasing availability of…

Recent advancements in artificial intelligence (AI), particularly foundation models (FMs), have revolutionized medical image analysis, demonstrating strong zero- and few-shot performance across diverse medical imaging tasks, from…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Praveenbalaji Rajendran , Mojtaba Safari , Wenfeng He , Mingzhe Hu , Shansong Wang , Jun Zhou , Xiaofeng Yang

Deep Learning has thrived on the emergence of biomedical big data. However, medical datasets acquired at different institutions have inherent bias caused by various confounding factors such as operation policies, machine protocols,…

Image and Video Processing · Electrical Eng. & Systems 2019-11-15 Yundong Zhang , Hang Wu , Huiye Liu , Li Tong , May D Wang

Seismic processing plays a crucial role in transforming raw data into high-quality subsurface images, pivotal for various geoscience applications. Despite its importance, traditional seismic processing techniques face challenges such as…

Computer Vision and Pattern Recognition · Computer Science 2025-05-12 Fabian Fuchs , Mario Ruben Fernandez , Norman Ettrich , Janis Keuper

A recent trend in deep learning algorithms has been towards training large scale models, having high parameter count and trained on big dataset. However, robustness of such large scale models towards real-world settings is still a…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Nishant Jain , Harkirat Behl , Yogesh Singh Rawat , Vibhav Vineet

Recent advances in deep learning have completely transformed the domain of computational pathology (CPath). More specifically, it has altered the diagnostic workflow of pathologists by integrating foundation models (FMs) and vision-language…

Machine Learning · Computer Science 2024-09-19 Dibaloke Chanda , Milan Aryal , Nasim Yahya Soltani , Masoud Ganji

The rapid development of machine learning (ML) and artificial intelligence (AI) applications requires the training of large numbers of models. This growing demand highlights the importance of training models without human supervision, while…

Machine Learning · Computer Science 2025-05-26 Alexey Boldyrev , Fedor Ratnikov , Andrey Shevelev

Rapid progress in computational pathology is increasingly driven by vision foundation models pretrained on vast histopathology datasets. While recent efforts have prioritized training on an ever-larger amount of patches, we take an…

Foundation models can be disruptive for future AI development by scaling up deep learning in terms of model size and training data's breadth and size. These models achieve state-of-the-art performance (often through further adaptation) on a…

Artificial Intelligence · Computer Science 2022-12-20 Johannes Schneider

Despite the promise of computational pathology foundation models, adapting them to specific clinical tasks remains challenging due to the complexity of whole-slide image (WSI) processing, the opacity of learned features, and the wide range…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Abdul Rahman Diab , Emily E. Karn , Renchin Wu , Emily S. Ruiz , William Lotter

Despite advances in deep learning, robustness under domain shift remains a major bottleneck in medical imaging settings. Findings on natural images suggest that deep neural models can show a strong textural bias when carrying out image…

Image and Video Processing · Electrical Eng. & Systems 2021-06-29 Seoin Chai , Daniel Rueckert , Ahmed E. Fetit

Foundation models, first introduced in 2021, refer to large-scale pretrained models (e.g., large language models (LLMs) and vision-language models (VLMs)) that learn from extensive unlabeled datasets through unsupervised methods, enabling…

Foundational models are trained on extensive datasets to capture the general trends of a domain. However, in medical imaging, the scarcity of data makes pre-training for every domain, modality, or task challenging. Continual learning offers…

Image and Video Processing · Electrical Eng. & Systems 2025-08-20 Mohammad Areeb Qazi , Munachiso S Nwadike , Ibrahim Almakky , Mohammad Yaqub , Numan Saeed

Medical image segmentation supports clinical workflows by precisely delineating anatomical structures and lesions. However, medical image datasets medical image datasets suffer from acquisition noise and annotation ambiguity, causing…

Artificial Intelligence · Computer Science 2026-04-14 Ruiyang Li , Fang Liu , Licheng Jiao , Xinglin Xie , Jiayao Hao , Shuo Li , Xu Liu , Jingyi Yang , Lingling Li , Puhua Chen , Wenping Ma

We present a deep transformation model for probabilistic regression. Deep learning is known for outstandingly accurate predictions on complex data but in regression tasks, it is predominantly used to just predict a single number. This…

Machine Learning · Statistics 2020-04-02 Beate Sick , Torsten Hothorn , Oliver Dürr

Machine learning has demonstrated remarkable performance over finite datasets, yet whether the scores over the fixed benchmarks can sufficiently indicate the model's performance in the real world is still in discussion. In reality, an ideal…

Computer Vision and Pattern Recognition · Computer Science 2024-05-17 Peiyan Zhang , Haoyang Liu , Chaozhuo Li , Xing Xie , Sunghun Kim , Haohan Wang

Inevitable domain and task discrepancies in real-world scenarios can impair the generalization performance of the pre-trained deep models for medical data. Therefore, we audaciously propose that we should build a general-purpose medical AI…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Huahui Yi , Ziyuan Qin , Qicheng Lao , Wei Xu , Zekun Jiang , Dequan Wang , Shaoting Zhang , Kang Li

Despite the significant potential of Foundation Models (FMs) in medical imaging, their application to prognosis prediction remains challenging due to data scarcity, class imbalance, and task complexity, which limit their clinical adoption.…

Computer Vision and Pattern Recognition · Computer Science 2026-01-16 Filippo Ruffini , Elena Mulero Ayllon , Linlin Shen , Paolo Soda , Valerio Guarrasi

Many healthcare applications are inherently multimodal, involving several physiological signals. As sensors for these signals become more common, improving machine learning methods for multimodal healthcare data is crucial. Pretraining…

Machine Learning · Computer Science 2024-10-23 Ching Fang , Christopher Sandino , Behrooz Mahasseni , Juri Minxha , Hadi Pouransari , Erdrin Azemi , Ali Moin , Ellen Zippi

Rapid development of large-scale pre-training has resulted in foundation models that can act as effective feature extractors on a variety of downstream tasks and domains. Motivated by this, we study the efficacy of pre-trained vision models…

Machine Learning · Computer Science 2022-07-05 Oleksiy Ostapenko , Timothee Lesort , Pau Rodríguez , Md Rifat Arefin , Arthur Douillard , Irina Rish , Laurent Charlin
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