Related papers: Unsupervised dimensionality reduction of polarimet…
In the present study, we consider the Extra-Membrane-Intra model (EMI) for the simulation of excitable tissues at the cellular level. We provide the (possibly large) system of partial differential equations (PDEs), equipped with ad hoc…
Preterm birth is associated with premature cervical remodeling, yet current clinical assessments cannot detect the underlying microstructural changes in collagen organization. We apply imaging Mueller polarimetry to murine cervical tissue…
Background and Aims: Limited methods exist to accurately characterize risk of malignant progression of liver lesions in patients undergoing surveillance for hepatocellular carcinoma (HCC). Enhancement pattern mapping (EPM) measures…
In hyperspectral imaging, spectral unmixing aims at decomposing the image into a set of reference spectral signatures corresponding to the materials present in the observed scene and their relative proportions in every pixel. While a linear…
Cell migration in fibreous extracellular matrix (ECM) is crucial to many physiological and pathological processes such as tissue regeneration, immune response and cancer progression. During migration, individual cells can generate active…
Neuronal and glial cells release diverse proteoglycans and glycoproteins, which aggregate in the extracellular space and form the extracellular matrix (ECM) that may in turn regulate major cellular functions. Brain cells also release…
Polarization is a degree of freedom of light carrying important information that is usually absent in intensity and spectral content. Imaging polarimetry is the process of determining the polarization state of light, either partially or…
Electron microscopy (EM) imaging offers unparalleled resolution for analyzing neural tissues, crucial for uncovering the intricacies of synaptic connections and neural processes fundamental to understanding behavioral mechanisms. Recently,…
The ability to locally degrade the extracellular matrix (ECM) and interact with the tumour microenvironment is a key process distinguishing cancer from normal cells, and is a critical step in the metastatic spread of the tumour. The…
Protrusions at the leading-edge of a cell play an important role in sensing the extracellular cues, during cellular spreading and motility. Recent studies provided indications that these protrusions wrap (coil) around the extra-cellular…
Control of the cytoskeleton and mechanical contacts with the extracellular environment are essential component of motility in eukaryotic cells. In the absence of signals, cells continuously rebuild the cytoskeleton and periodically extend…
Depolarization of circularly polarized light scattered from biological tissues depends on structural changes in cell nuclei, which can provide valuable information for differentiating cancer tissues concealed in healthy tissues. In this…
The human body is mysterious, consisting of innumerable fine and complex structures and a vast amount of information. The field of modern pathology has been systematized around the findings and observations obtained from light microscopy.…
This article aims to provide a brief overview of both established and novel ellipsometry techniques, as well as their applications. Ellipsometry is an indirect optical technique in that information about the physical properties of a sample…
Many cellular processes require a polarization axis which generally initially emerges as an inhomogeneous distribution of molecular markers in the cell. We present a simple analytical model of a general mechanism of cell polarization taking…
Colonoscopy is a procedure to detect colorectal polyps which are the primary cause for developing colorectal cancer. However, polyp segmentation is a challenging task due to the diverse shape, size, color, and texture of polyps, shuttle…
Multicellular migration and pattern formation play important roles in developmental biology, cancer metastasis and wound healing. To understand the collective cell dynamics in three dimensional extracellular matrix (ECM), we have developed…
Mueller matrices provide a complete description of a medium's response to excitation by polarized light, and their characterization is important across a broad range of applications from ellipsometry in material science to polarimetry in…
Given a hyperspectral image, the problem of hyperspectral unmixing (HU) is to identify the endmembers (or materials) and the abundance (or endmembers' contributions on pixels) that underlie the image. HU can be seen as a matrix…
Collagen fibers, an important component of the extracellular matrix (ECM), can both inhibit and promote cellular migration. {\it In-vitro} studies have revealed that the fibers' orientations are crucial to cellular invasion, while {\it…