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The construction of high-quality parallel corpora for translation research has increasingly evolved from simple sentence alignment to complex, multi-layered annotation tasks. This methodological shift presents significant challenges for…

Computation and Language · Computer Science 2026-02-12 Baorong Huang , Ali Asiri

Understanding cell identity and function through single-cell level sequencing data remains a key challenge in computational biology. We present a novel framework that leverages gene-specific textual annotations from the NCBI Gene database…

Genomics · Quantitative Biology 2025-05-14 Douglas Jiang , Zilin Dai , Luxuan Zhang , Qiyi Yu , Haoqi Sun , Feng Tian

In this work, we introduce a novel framework that employs cluster annotation to boost active learning by reducing the number of human interactions required to train deep neural networks. Instead of annotating single samples individually,…

Machine Learning · Computer Science 2019-01-28 Fábio Perez , Rémi Lebret , Karl Aberer

Numerous tools have been recently developed to predict disease phenotypes using single-cell RNA sequencing (RNA-seq) data. CloudPred is an end-to-end differentiable learning algorithm coupled with a biologically informed mixture model,…

Genomics · Quantitative Biology 2024-02-20 Hossein Moghimianavval , Baharan Meghdadi , Tasmine Clement , Man I Wu

Many neuroscientific applications require robust and accurate localization of neurons. It is still an unsolved problem because of the enormous variation in intensity, texture, spatial overlap, morphology and background artifacts. In…

Quantitative Methods · Quantitative Biology 2021-03-22 Tamal Batabyal , Aijaz Ahmad Naik , Daniel Weller , Jaideep Kapur

Inferring gene regulatory networks (GRNs) from single-cell RNA sequencing (scRNA-seq) data is a complex challenge that requires capturing the intricate relationships between genes and their regulatory interactions. In this study, we tackle…

Machine Learning · Computer Science 2024-07-26 Sindhura Kommu , Yizhi Wang , Yue Wang , Xuan Wang

Column type annotation is vital for tasks like data cleaning, integration, and visualization. Recent solutions rely on resource-intensive language models fine-tuned on well-annotated columns from a particular set of tables, i.e., a source…

Computation and Language · Computer Science 2026-02-10 Yushi Sun , Xujia Li , Nan Tang , Quanqing Xu , Chuanhui Yang , Lei Chen

The proliferation of digital microscopy images, driven by advances in automated whole slide scanning, presents significant opportunities for biomedical research and clinical diagnostics. However, accurately annotating densely packed…

Computer Vision and Pattern Recognition · Computer Science 2025-04-25 Chen Liu , Danqi Liao , Alejandro Parada-Mayorga , Alejandro Ribeiro , Marcello DiStasio , Smita Krishnaswamy

Rapid advancements in high-throughput single-cell RNA-seq (scRNA-seq) technologies and experimental protocols have led to the generation of vast amounts of genomic data that populates several online databases and repositories. Here, we…

Genomics · Quantitative Biology 2024-04-17 Mahnoor N. Gondal , Saad Ur Rehman Shah , Arul M. Chinnaiyan , Marcin Cieslik

As model families, training recipes, and compute budgets become increasingly standardized, further gains in machine learning systems depend increasingly on data. Yet data engineering remains largely manual and ad hoc: practitioners…

Modeling the dynamics of cellular differentiation is fundamental to advancing the understanding and treatment of diseases associated with this process, such as cancer. With the rapid growth of single-cell datasets, this has also become a…

Although the annotation paradigm based on Large Language Models (LLMs) has made significant breakthroughs in recent years, its actual deployment still has two core bottlenecks: first, the cost of calling commercial APIs in large-scale…

Computation and Language · Computer Science 2025-06-23 Yao Lu , Zhaiyuan Ji , Jiawei Du , Yu Shanqing , Qi Xuan , Tianyi Zhou

Microscopy data collections are becoming larger and more frequent. Accurate and precise quantitative analysis tools like cell instance segmentation are necessary to benefit from them. This is challenging due to the variability in the data,…

Computer Vision and Pattern Recognition · Computer Science 2024-02-28 Ram J. Zaveri , Voke Brume , Gianfranco Doretto

Manual annotation of medical images is a labor-intensive and time-consuming process, posing a significant bottleneck in the development and deployment of robust medical imaging AI systems. This paper introduces a novel hands-free Human-AI…

Image and Video Processing · Electrical Eng. & Systems 2025-07-29 Yizhe Zhang

Single-cell multi-omics (scMulti-omics) refers to the paired multimodal data, such as Cellular Indexing of Transcriptomes and Epitopes by Sequencing (CITE-seq), where the regulation of each cell was measured from different modalities, i.e.…

Machine Learning · Computer Science 2024-10-18 Dian Meng , Bohao Xing , Xinlei Huang , Yanran Liu , Yijun Zhou , Yongjun xiao , Zitong Yu , Xubin Zheng

Real-world domain experts (e.g., doctors) rarely annotate only a decision label in their day-to-day workflow without providing explanations. Yet, existing low-resource learning techniques, such as Active Learning (AL), that aim to support…

Computation and Language · Computer Science 2023-10-24 Bingsheng Yao , Ishan Jindal , Lucian Popa , Yannis Katsis , Sayan Ghosh , Lihong He , Yuxuan Lu , Shashank Srivastava , Yunyao Li , James Hendler , Dakuo Wang

We present MedCATTrainer an interface for building, improving and customising a given Named Entity Recognition and Linking (NER+L) model for biomedical domain text. NER+L is often used as a first step in deriving value from clinical text.…

Human-Computer Interaction · Computer Science 2023-02-28 Thomas Searle , Zeljko Kraljevic , Rebecca Bendayan , Daniel Bean , Richard Dobson

Data annotation is essential for supervised learning, yet producing accurate, unbiased, and scalable labels remains challenging as datasets grow in size and modality. Traditional human-centric pipelines are costly, slow, and prone to…

Machine Learning · Computer Science 2026-02-04 Subhodeep Ghosh , Bayan Divaaniaazar , Md Ishat-E-Rabban , Spencer Clarke , Senjuti Basu Roy

Cellular automata have been useful artificial models for exploring how relatively simple rules combined with spatial memory can give rise to complex emergent patterns. Moreover, studying the dynamics of how rules emerge under artificial…

Cellular Automata and Lattice Gases · Physics 2014-07-11 Theodore P. Pavlic , Alyssa M. Adams , Paul C. W. Davies , Sara Imari Walker

We present SwellShark, a framework for building biomedical named entity recognition (NER) systems quickly and without hand-labeled data. Our approach views biomedical resources like lexicons as function primitives for autogenerating weak…

Computation and Language · Computer Science 2017-04-24 Jason Fries , Sen Wu , Alex Ratner , Christopher Ré