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With the rapid expansion of unstructured clinical texts in electronic health records (EHRs), clinical named entity recognition (NER) has become a crucial technique for extracting medical information. However, traditional supervised models…

Computation and Language · Computer Science 2026-03-31 Xinli Tao , Xin Dong , Xuezhong Zhou

This paper presents an iterative approach to performing Scientific Named Entity Recognition (SciNER) using BERT-based models. We leverage transfer learning to fine-tune pretrained models with a small but high-quality set of manually…

Computation and Language · Computer Science 2025-02-25 Kartik Gupta

Single-cell RNA-sequencing (scRNA-seq) stands as a powerful tool for deciphering cellular heterogeneity and exploring gene expression profiles at high resolution. However, its high cost renders it impractical for extensive sample cohorts…

Accurately annotating and controlling protein function from sequence data remains a major challenge, particularly within homologous families where annotated sequences are scarce and structural variation is minimal. We present a two-stage…

Quantitative Methods · Quantitative Biology 2025-07-22 Lorenzo Rosset , Martin Weigt , Francesco Zamponi

Single-cell-resolution spatial transcriptomics profiles gene expression at cellular locations in native tissues, yet accurate cell-type annotation remains challenging: imaging-based platforms are constrained by targeted gene panels, whereas…

Cell Behavior · Quantitative Biology 2026-05-27 Yiyang Zhang , Bokai Zhao , Xiaoru Zhang , Zongchang Du , Xiaojuan Sun , Tianzi Jiang

The recently released Segment Anything Model (SAM) has shown powerful zero-shot segmentation capabilities through a semi-automatic annotation setup in which the user can provide a prompt in the form of clicks or bounding boxes. There is…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Benjamin Towle , Xin Chen , Ke Zhou

Semantic human matting aims to estimate the per-pixel opacity of the foreground human regions. It is quite challenging and usually requires user interactive trimaps and plenty of high quality annotated data. Annotating such kind of data is…

Computer Vision and Pattern Recognition · Computer Science 2020-04-13 Jinlin Liu , Yuan Yao , Wendi Hou , Miaomiao Cui , Xuansong Xie , Changshui Zhang , Xian-sheng Hua

Instruction fine-tuning is crucial in NLP tasks, enhancing pretrained models' instruction-following capabilities and task-specific performance. However, obtaining high-quality fine-tuning data for large models is challenging due to data…

Computation and Language · Computer Science 2025-06-05 Liang Yue , Yihong Tang , Kehai Chen , Jie Liu , Min Zhang

An increasing number of public datasets have shown a transformative impact on automated medical segmentation. However, these datasets are often with varying label quality, ranging from manual expert annotations to AI-generated…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Yixiong Chen , Zongwei Zhou , Alan Yuille

We present a lightweight annotation tool, the Data AnnotatoR Tool (DART), for the general task of labeling structured data with textual descriptions. The tool is implemented as an interactive application that reduces human efforts in…

Computation and Language · Computer Science 2020-12-02 Ernie Chang , Jeriah Caplinger , Alex Marin , Xiaoyu Shen , Vera Demberg

Functional MRI (fMRI) and single-cell transcriptomics are pivotal in Alzheimer's disease (AD) research, each providing unique insights into neural function and molecular mechanisms. However, integrating these complementary modalities…

Quantitative Methods · Quantitative Biology 2025-02-06 Yu-An Huang , Yao Hu , Yue-Chao Li , Xiyue Cao , Xinyuan Li , Kay Chen Tan , Zhu-Hong You , Zhi-An Huang

Classifying and analyzing human cells is a lengthy procedure, often involving a trained professional. In an attempt to expedite this process, an active area of research involves automating cell classification through use of deep…

Computer Vision and Pattern Recognition · Computer Science 2022-03-15 Reece Walsh , Mohamed H. Abdelpakey , Mohamed S. Shehata , Mostafa M. Mohamed

Supervised named entity recognition (NER) in the biomedical domain depends on large sets of annotated texts with the given named entities. The creation of such datasets can be time-consuming and expensive, while extraction of new entities…

Computation and Language · Computer Science 2024-08-27 Miloš Košprdić , Nikola Prodanović , Adela Ljajić , Bojana Bašaragin , Nikola Milošević

Recent advances in tissue microarray technology have allowed immunohistochemistry to become a powerful medium-to-high throughput analysis tool, particularly for the validation of diagnostic and prognostic biomarkers. However, as study size…

Methodology · Statistics 2015-03-18 Donghui Yan , Pei Wang , Michael Linden , Beatrice Knudsen , Timothy Randolph

Prognostic signatures play an important role in clinical research, offering insights into the potential health outcomes of patients and guiding therapeutic decisions. Although single-gene prognostic biomarkers are valuable, multi-gene…

Quantitative Methods · Quantitative Biology 2023-11-15 Xu Zhang , Lei Chen

Artificial Intelligence (AI) has emerged as a valuable tool for assisting radiologists in breast cancer detection and diagnosis. However, the success of AI applications in this domain is restricted by the quantity and quality of available…

Computer Vision and Pattern Recognition · Computer Science 2024-05-31 Marta Buetas Arcas , Richard Osuala , Karim Lekadir , Oliver Díaz

This technique report introduces TexSmart, a text understanding system that supports fine-grained named entity recognition (NER) and enhanced semantic analysis functionalities. Compared to most previous publicly available text understanding…

Accurate cell counting in microscopic images is important for medical diagnoses and biological studies. However, manual cell counting is very time-consuming, tedious, and prone to subjective errors. We propose a new density regression-based…

Computer Vision and Pattern Recognition · Computer Science 2019-03-25 Shenghua He , Kyaw Thu Minn , Lilianna Solnica-Krezel , Hua Li , Mark Anastasio

While single-cell RNA sequencing provides an understanding of the transcriptome of individual cells, its high sparsity, often termed dropout, hampers the capture of significant cell-cell relationships. Here, we propose scFP (single-cell…

Computational Engineering, Finance, and Science · Computer Science 2023-07-24 Sukwon Yun , Junseok Lee , Chanyoung Park

Objective: Medical image datasets with pixel-level labels tend to have a limited number of organ or tissue label classes annotated, even when the images have wide anatomical coverage. With supervised learning, multiple classifiers are…

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