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Infectious diseases are a threat for human health with tremendous impact on our society at large. The recent COVID-19 pandemic, caused by the SARS-CoV-2, is the latest example of a highly infectious disease ravaging the world, since late…

Populations and Evolution · Quantitative Biology 2021-09-17 Giacomo Cacciapaglia , Corentin Cot , Michele Della Morte , Stefan Hohenegger , Francesco Sannino , Shahram Vatani

Foundation models have emerged as a powerful approach for processing electronic health records (EHRs), offering flexibility to handle diverse medical data modalities. In this study, we present a comprehensive benchmark that evaluates the…

Machine Learning · Computer Science 2025-07-22 Kunyu Yu , Rui Yang , Jingchi Liao , Siqi Li , Huitao Li , Irene Li , Yifan Peng , Rishikesan Kamaleswaran , Nan Liu

Modeling and forecasting the spread of infectious diseases is essential for effective public health decision-making. Traditional epidemiological models rely on expert-defined frameworks to describe complex dynamics, while neural networks,…

Machine Learning · Computer Science 2024-12-31 Jianda Du , Senwei Liang , Chunmei Wang

To be fully useful for public health practice, models for epidemic response must be able to do more than predict -- it is also important to incorporate the mechanisms underlying transmission dynamics to enable policymakers and practitioners…

Quantitative Methods · Quantitative Biology 2025-05-26 Jiale Tan , Marisa C. Eisenberg

Timely and robust influenza incidence forecasting is critical for public health decision-making. This paper presents MAESTRO (Multi-modal Adaptive Estimation for Temporal Respiratory Disease Outbreak), a novel, unified framework that…

Machine Learning · Computer Science 2025-09-22 Hong Liu , Kerui Cen , Yanxing Chen , Zige Liu , Dong Chen , Zifeng Yang , Chitin Hon

In this article, we introduce the R package EpiILM, which provides tools for simulation from, and inference for, discrete-time individual-level models of infectious disease transmission proposed by Deardon et al. (2010). The inference is…

Applications · Statistics 2020-04-02 Vineetha Warriyar K. V. , Waleed Almutiry , Rob Deardon

The transmission dynamics of an epidemic are rarely homogeneous. Super-spreading events and super-spreading individuals are two types of heterogeneous transmissibility. Inference of super-spreading is commonly carried out on secondary case…

Quantitative Methods · Quantitative Biology 2025-01-23 Hannah Craddock , Simon EF Spencer , Xavier Didelot

Airborne pandemics have caused millions of deaths worldwide, large-scale economic losses, and catastrophic sociological shifts in human history. Researchers have developed multiple mathematical models and computational frameworks to…

Information Retrieval · Computer Science 2024-06-18 Teddy Lazebnik , Ariel Alexi

Multilevel modeling is increasingly relevant in the context of modelling and simulation since it leads to several potential benefits, such as software reuse and integration, the split of semantically separated levels into sub-models, the…

Performance · Computer Science 2024-03-26 Luca Serena , Moreno Marzolla , Gabriele D'Angelo , Stefano Ferretti

We present an end-to-end differentiable molecular simulation framework (DIMOS) for molecular dynamics and Monte Carlo simulations. DIMOS easily integrates machine-learning-based interatomic potentials and implements classical force fields…

Simulation models are an absolute necessity in the human and social sciences, which can only very exceptionally use experimental science methods to construct their knowledge. Models enable the simulation of social processes by replacing the…

Computers and Society · Computer Science 2020-01-06 J. Raimbault , D. Pumain

Running complex sets of machine learning experiments is challenging and time-consuming due to the lack of a unified framework. This leaves researchers forced to spend time implementing necessary features such as parallelization, caching,…

Machine Learning · Computer Science 2023-11-22 Zac Pullar-Strecker , Xinglong Chang , Liam Brydon , Ioannis Ziogas , Katharina Dost , Jörg Wicker

Medical evacuation is one of the United States Army's most storied and critical mission sets, responsible for efficiently and expediently evacuating the battlefield ill and injured. Medical evacuation planning involves designing a robust…

Artificial Intelligence · Computer Science 2026-02-03 Jeremy Fischer , Mahdi Al-Husseini , Ram Krishnamoorthy , Vishal Kumar , Mykel J. Kochenderfer

Mathematical modeling of disease outbreaks can infer the future trajectory of an epidemic, which can inform policy decisions. Another task is inferring the origin of a disease, which is relatively difficult with current mathematical models.…

Physics and Society · Physics 2022-08-31 Mehrad Ansari , David Soriano-Paños , Gourab Ghoshal , Andrew D. White

The spreading dynamics of infectious diseases is influenced by individual behaviours, which are in turn affected by the level of awareness about the epidemic. Modelling the co-evolution of disease transmission and behavioural changes within…

Physics and Society · Physics 2026-02-27 Daniele Proverbio , Riccardo Tessarin , Giulia Giordano

Epidemic models are invaluable tools to understand and implement strategies to control the spread of infectious diseases, as well as to inform public health policies and resource allocation. However, current modeling approaches have…

Methodology · Statistics 2026-05-12 Caitlin Ward , Rob Deardon , Alexandra M. Schmidt

As Large Language Models increasingly power role-playing applications, simulating patients has become a valuable tool for training counselors and scaling therapeutic assessment. However, prior work is fragmented: existing approaches rely on…

Computation and Language · Computer Science 2026-02-13 Sahand Sabour , TszYam NG , Minlie Huang

Accurate immunological models offer the possibility of performing highthroughput experiments in silico that can predict, or at least suggest, in vivo phenomena. In this chapter, we compare various models of immunological memory. We first…

Artificial Intelligence · Computer Science 2010-07-05 Simon Garret , Martin Robbins , Joanne Walker , William Wilson , Uwe Aickelin

The patterns of human mobility play a key role in the spreading of infectious diseases and thus represent a key ingredient of epidemic modeling and forecasting. Unfortunately, as the Covid-19 pandemic has dramatically highlighted, for the…

Physics and Society · Physics 2024-08-28 Antonio Desiderio , Giulio Cimini , Gaetano Salina

Epidemic modeling is essential for public health planning, yet traditional approaches rely on fixed model classes that require manual redesign as pathogens, policies, and scenario assumptions evolve. We introduce EPIAGENT, an agentic…