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We experimentally and theoretically study the thermodynamically optimal control of interacting multiple-particle systems, focusing on collections of colloidal particles individually confined in optical traps. We investigate protocols that…

Soft Condensed Matter · Physics 2026-03-19 Samuel Monter , Lars T. Stutzer , Sarah A. M. Loos , Clemens Bechinger

This paper proposes a new thermodynamic hypothesis that states that a nonlinear natural system that is not isolated and involves positive feedbacks tends to minimize its resistance to the flow process through it that is imposed by its…

Geophysics · Physics 2013-02-26 Hui-Hai Liu

We study the thermodynamics of open systems weakly driven out-of-equilibrium by nonconservative and time-dependent forces using the linear regime of stochastic thermodynamics. We make use of conservation laws to identify the potential and…

Statistical Mechanics · Physics 2022-10-13 Danilo Forastiere , Riccardo Rao , Massimiliano Esposito

This paper considers sequential adaptive estimation of sparse signals under a constraint on the total sensing effort. The advantage of adaptivity in this context is the ability to focus more resources on regions of space where signal…

Methodology · Statistics 2013-04-03 Dennis Wei , Alfred O. Hero

Biological and living systems process information across spatiotemporal scales, exhibiting the hallmark ability to constantly modulate their behavior to ever-changing and complex environments. In the presence of repeated stimuli, a…

Statistical Mechanics · Physics 2025-02-04 Giorgio Nicoletti , Matteo Bruzzone , Samir Suweis , Marco Dal Maschio , Daniel Maria Busiello

We present a spatially-extended system of chemical reactions exhibiting adaptation to time-dependent influxes of reactants. Here adaptation is defined as improved reproductive success, namely the ability of one of the many locally stable…

Statistical Mechanics · Physics 2025-12-02 Olivier Rivoire , Guy Bunin

Organisms may respond to local stimuli that benefit or threaten their fitness. The adaptive movement behaviour may allow individuals to adjust their speed to maximise the chances of being in comfort zones, where death risk is minimal. We…

Populations and Evolution · Quantitative Biology 2022-12-27 M. Tenorio , E. Rangel , J. Menezes

Accurate phase diagram calculation from molecular dynamics requires systematic treatment and convergence of statistical averages. In this work we propose a Gaussian process regression based framework for reconstructing the free energy…

Computational Physics · Physics 2021-11-02 V. Ladygin , I. Beniya , E. Makarov , A. Shapeev

Generative models of complex systems often require post-hoc parameter adjustments to produce useful outputs. For example, energy-based models for protein design are sampled at an artificially low ''temperature'' to generate novel,…

Quantitative Methods · Quantitative Biology 2025-12-11 Peter W Fields , Vudtiwat Ngampruetikorn , David J Schwab , Stephanie E Palmer

As in the preceding paper we aim at identifying the effective theory that describes the fluctuations of the local overlap with an equilibrium reference configuration close to a putative thermodynamic glass transition. We focus here on the…

Statistical Mechanics · Physics 2018-11-21 G. Biroli , C. Cammarota , G. Tarjus , M. Tarzia

A central goal of protein-folding theory is to predict the stochastic dynamics of transition paths --- the rare trajectories that transit between the folded and unfolded ensembles --- using only thermodynamic information, such as a…

Biomolecules · Quantitative Biology 2018-08-09 William M. Jacobs , Eugene I. Shakhnovich

We develop a microscopic theory to analyze the phase behaviour and compute correlation functions of dense assemblies of soft repulsive particles both at finite temperature, as in colloidal materials, and at vanishing temperature, a…

Disordered Systems and Neural Networks · Physics 2011-11-09 Ludovic Berthier , Hugo Jacquin , Francesco Zamponi

Responsive, adaptive and intelligent are widely used but inconsistently defined descriptors of soft matter. A conceptual framework is proposed in which the three classes are information channels of increasing architectural complexity: a…

Soft Condensed Matter · Physics 2026-05-29 George S. Attard

The thermodynamic entropy of coarse-grained (CG) models stands as one of the most important properties for quantifying the missing information during the CG process and for establishing transferable (or extendible) CG interactions. However,…

Chemical Physics · Physics 2024-04-10 Jaehyeok Jin , David R. Reichman

Many natural systems exhibit tipping points where changing environmental conditions spark a sudden shift to a new and sometimes quite different state. Global climate change is often associated with the stability of marine carbon stocks. We…

Dynamical Systems · Mathematics 2024-06-19 Jianyu Chen , Jianyu Hu , Wei Wei , Jinqiao Duan

Reaction-diffusion systems offer a powerful framework for understanding self-organized patterns in biological systems, yet controlling these patterns remains a significant challenge. As a consequence, we present a rigorous framework of…

Optimization and Control · Mathematics 2026-04-13 Mohamed Amine Ouchdiri , Hamza Faquir , Saad Benjelloun , Mohamed Adlene Maghenem , Irene Otero-Muras , Adnane Saoud

This paper addresses the problem of active learning of a multi-output Gaussian process (MOGP) model representing multiple types of coexisting correlated environmental phenomena. In contrast to existing works, our active learning problem…

Machine Learning · Statistics 2015-11-25 Yehong Zhang , Trong Nghia Hoang , Kian Hsiang Low , Mohan Kankanhalli

A system consisting of a doubly clamped beam with an attached body (slider) free to move along the beam has been studied recently by multiple research groups. Under harmonic base excitation, the system has the capacity to passively adapt…

Adaptation and Self-Organizing Systems · Physics 2022-08-02 Florian Müller , Maximilian Beck , Malte Krack

For systems in an externally controllable time-dependent potential, the optimal protocol minimizes the mean work spent in a finite-time transition between two given equilibrium states. For overdamped dynamics which ignores inertia effects,…

Statistical Mechanics · Physics 2008-07-23 Alex Gomez-Marin , Tim Schmiedl , Udo Seifert

Active sensing is traditionally defined as the expenditure of energy, typically in the form of movement, for obtaining information. Here, we propose that the combination of reliance on adaptive sensors, the linkage between movement and…

Neurons and Cognition · Quantitative Biology 2026-05-25 Andrew Lamperski , Debojyoti Biswas , Eric S. Fortune , John Guckenheimer , Kathleen Hoffman , Noah J. Cowan
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