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The complete physical understanding of the optimization of the thermodynamic work still is an important open problem in stochastic thermodynamics. We address this issue using the Hamiltonian approach of linear response theory in finite time…

Statistical Mechanics · Physics 2022-08-18 Pierre Nazé , Sebastian Deffner , Marcus V. S. Bonança

We present a novel formulation for biochemical reaction networks in the context of signal transduction. The model consists of input-output transfer functions, which are derived from differential equations, using stable equilibria. We select…

Molecular Networks · Quantitative Biology 2013-02-26 Gabriele Scheler

A system responding to a stochastic driving signal can be interpreted as computing, by means of its dynamics, an implicit model of the environmental variables. The system's state retains information about past environmental fluctuations,…

Statistical Mechanics · Physics 2012-10-09 Susanne Still , David A. Sivak , Anthony J. Bell , Gavin E. Crooks

Target-oriented discovery under limited evaluation budgets requires making reliable progress in high-dimensional, heterogeneous design spaces where each new measurement is costly, whether experimental or high-fidelity simulation. We present…

Machine Learning · Computer Science 2026-02-04 Yixuan Zhang , Zhiyuan Li , Weijia He , Mian Dai , Chen Shen , Teng Long , Hongbin Zhang

In many scientific and engineering problems, noise and nonlinearity are unavoidable, which could induce interesting mathematical problem such as transition phenomena. This paper focuses on efficiently discovering the most probable…

Optimization and Control · Mathematics 2023-06-08 Jin Guo , Ting Gao , Peng Zhang , Jiequn Han , Jinqiao Duan

This work is devoted to deriving the Onsager-Machlup function for a class of stochastic dynamical systems under (non-Gaussian) Levy noise as well as (Gaussian) Brownian noise, and examining the corresponding most probable paths. This…

Mathematical Physics · Physics 2020-01-08 Ying Chao , Jinqiao Duan

The Thermodynamic Formalism provides a rigorous mathematical framework to study quantitative and qualitative aspects of dynamical systems. At its core there is a variational principle corresponding, in its simplest form, to the Maximum…

Neurons and Cognition · Quantitative Biology 2020-12-30 Rodrigo Cofré , Cesar Maldonado , Bruno Cessac

Robots and animals both experience the world through their bodies and senses. Their embodiment constrains their experiences, ensuring they unfold continuously in space and time. As a result, the experiences of embodied agents are…

Machine Learning · Computer Science 2024-05-28 Thomas A. Berrueta , Allison Pinosky , Todd D. Murphey

Biological sensory receptors provide excellent examples of microscopic scale information transduction amidst stochastic noise. We argue that stochasticity is not always a hindrance to sensing. Instead, it could allow a single stochastic…

Statistical Mechanics · Physics 2023-04-24 Asawari Pagare , Sa Hoon Min , Zhiyue Lu

We introduce a constructive framework for assigning thermodynamic structure to an arbitrary data system from its measured microstates. Starting from an empirical distribution over configurations, we first infer a data-driven energy function…

Statistical Mechanics · Physics 2026-04-29 George-Rafael Domenikos , Lock Yue Chew , Victoria Leong

Humans rely on multimodal perception to form representations of the world. This implies that environmental stimuli must remain consistent and predictable throughout their journey to our sensory organs. When it comes to vision,…

Materials Science · Physics 2024-08-14 Thomas Daunizeau , Sinan Haliyo , Vincent Hayward

Game theory is playing more and more important roles in understanding complex systems and in investigating intelligent machines with various uncertainties. As a starting point, we consider the classical two-player zero-sum linear-quadratic…

Optimization and Control · Mathematics 2022-04-20 Nian Liu , Lei Guo

We show that a rate of conditional Shannon entropy reduction, characterizing the learning of an internal process about an external process, is bounded by the thermodynamic entropy production. This approach allows for the definition of an…

Biological Physics · Physics 2014-11-07 Andre C. Barato , David Hartich , Udo Seifert

Thermal conditions in the urban canopy exhibit stochastic variability driven by varied radiative fluxes and turbulent wind fields, requiring probabilistic rather than deterministic prediction methods. This study presents a probabilistic…

Applied Physics · Physics 2025-12-10 Shisheng Chen , Ruohan Xu , Nyuk Hien Wong , Shanshan Tong , Jiashuo Wang , Matthaios Santamouris

It is shown that an exact solution of the transient dynamics of an associative memory model storing an infinite number of limit cycles with l finite steps by means of the path-integral analysis. Assuming the Maxwell construction ansatz, we…

Disordered Systems and Neural Networks · Physics 2007-05-23 Kazushi Mimura , Masaki Kawamura , Masato Okada

Nonequilibrium physics encompasses a broad range of natural and synthetic small-scale systems. Optimizing transitions of such systems will be crucial for the development of nanoscale technologies and may reveal the physical principles…

Statistical Mechanics · Physics 2015-09-23 Patrick R. Zulkowski , Michael R. DeWeese

This work presents a systematic methodology for describing the transient dynamics of coarse-grained molecular systems inferred from all-atom simulated data. We suggest Langevin-type dynamics where the coarse-grained interaction potential…

Numerical Analysis · Mathematics 2023-09-22 G. Baxevani , V. Harmandaris , E. Kalligiannaki , I. Tsantili

In various biological systems information from many noisy molecular receptors must be integrated into a collective response. A striking example is the thermal imaging organ of pit vipers. Single nerve fibers in the organ reliably respond to…

Biological Physics · Physics 2024-05-31 Isabella R. Graf , Benjamin B. Machta

The density of states of continuous models is known to span many orders of magnitudes at different energies due to the small volume of phase space near the ground state. Consequently, the traditional Wang-Landau sampling which uses the same…

Statistical Mechanics · Physics 2013-11-20 Yang Wei Koh , Hwee Kuan Lee , Yutaka Okabe

In decision-dependent games, multiple players optimize their decisions under a data distribution that shifts with their joint actions, creating complex dynamics in applications like market pricing. A practical consequence of these dynamics…

Computer Science and Game Theory · Computer Science 2025-09-04 Guangzheng Zhong , Yang Liu , Jiming Liu
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