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In this paper, we propose a novel system that integrates state-of-the-art, domain-specific large language models with advanced information retrieval techniques to deliver comprehensive and context-aware responses. Our approach facilitates…

Evaluating the output of generative large language models (LLMs) is challenging and difficult to scale. Many evaluations of LLMs focus on tasks such as single-choice question-answering or text classification. These tasks are not suitable…

Information Retrieval · Computer Science 2025-01-20 Sebastian Heineking , Jonas Probst , Daniel Steinbach , Martin Potthast , Harrisen Scells

Question answering (QA) can only make progress if we know if an answer is correct, but for many of the most challenging and interesting QA examples, current evaluation metrics to determine answer equivalence (AE) often do not align with…

Computation and Language · Computer Science 2024-07-02 Zongxia Li , Ishani Mondal , Yijun Liang , Huy Nghiem , Jordan Boyd-Graber

Timely and accurate situational reports are essential for humanitarian decision-making, yet current workflows remain largely manual, resource intensive, and inconsistent. We present a fully automated framework that uses large language…

Computation and Language · Computer Science 2025-12-23 Ivan Decostanzi , Yelena Mejova , Kyriaki Kalimeri

Recent advances in large language models (LLMs) and biomedical foundation models (BioFMs) have achieved strong results in biological text reasoning, molecular modeling, and single-cell analysis, yet they remain siloed in disjoint embedding…

Quantitative Methods · Quantitative Biology 2025-10-03 Ching-Huei Tsou , Michal Ozery-Flato , Ella Barkan , Diwakar Mahajan , Ben Shapira

Clinical question answering systems have the potential to provide clinicians with relevant and timely answers to their questions. Nonetheless, despite the advances that have been made, adoption of these systems in clinical settings has been…

Large Language Models (LLMs) have demonstrated impressive capabilities in complex reasoning tasks. However, they can be easily misled by unfaithful arguments during conversations, even when their original statements are correct. To this…

Computation and Language · Computer Science 2025-01-03 Yong Zhao , Yang Deng , See-Kiong Ng , Tat-Seng Chua

Retrieval Augmented Generation (RAG) has emerged as a powerful application of Large Language Models (LLMs), revolutionizing information search and consumption. RAG systems combine traditional search capabilities with LLMs to generate…

Information Retrieval · Computer Science 2025-06-12 Harsh Maheshwari , Srikanth Tenneti , Alwarappan Nakkiran

Biomedical research results are being published at a high rate, and with existing search engines, the vast amount of published work is usually easily accessible. However, reproducing published results, either experimental data or…

Molecular Networks · Quantitative Biology 2017-06-19 Kai-Wen Liang , Qinsi Wang , Cheryl Telmer , Divyaa Ravichandran , Peter Spirtes , Natasa Miskov-Zivanov

Large Language Models (LLMs) have swiftly emerged as vital resources for different applications in the biomedical and healthcare domains; however, these models encounter issues such as generating inaccurate information or hallucinations.…

Computation and Language · Computer Science 2024-05-06 Mingchen Li , Halil Kilicoglu , Hua Xu , Rui Zhang

Large Language Models (LLMs) have demonstrated remarkable adaptability, showcasing their capacity to excel in tasks for which they were not explicitly trained. However, despite their impressive natural language processing (NLP)…

Computation and Language · Computer Science 2023-09-08 Supun Manathunga , Isuru Hettigoda

We introduce SelfCite, a novel self-supervised approach that aligns LLMs to generate high-quality, fine-grained, sentence-level citations for the statements in their generated responses. Instead of only relying on costly and labor-intensive…

Computation and Language · Computer Science 2025-06-17 Yung-Sung Chuang , Benjamin Cohen-Wang , Shannon Zejiang Shen , Zhaofeng Wu , Hu Xu , Xi Victoria Lin , James Glass , Shang-Wen Li , Wen-tau Yih

The increasing complexity of clinical decision-making, alongside the rapid expansion of electronic health records (EHR), presents both opportunities and challenges for delivering data-informed care. This paper proposes a clinical decision…

Artificial Intelligence · Computer Science 2025-10-03 Leon Garza , Anantaa Kotal , Michael A. Grasso , Emre Umucu

Large language models (LLMs) have achieved remarkable advancements in natural language understanding and generation. However, one major issue towards their widespread deployment in the real world is that they can generate "hallucinated"…

Computation and Language · Computer Science 2024-04-04 Xi Ye , Ruoxi Sun , Sercan Ö. Arik , Tomas Pfister

Literature review requires researchers to synthesize a large amount of information and is increasingly challenging as the scientific literature expands. In this work, we investigate the potential of LLMs for producing hierarchical…

Computation and Language · Computer Science 2024-07-24 Chao-Chun Hsu , Erin Bransom , Jenna Sparks , Bailey Kuehl , Chenhao Tan , David Wadden , Lucy Lu Wang , Aakanksha Naik

LLMs have demonstrated impressive proficiency in generating coherent and high-quality text, making them valuable across a range of text-generation tasks. However, rigorous evaluation of this generated content is crucial, as ensuring its…

Biomedical semantic question answering rooted in information retrieval can play a crucial role in keeping up to date with vast, rapidly evolving and ever-growing biomedical literature. A robust system can help researchers, healthcare…

Information Retrieval · Computer Science 2025-07-09 Shashank Verma , Fengyi Jiang , Xiangning Xue

LLM evaluation is challenging even the case of base models. In real world deployments, evaluation is further complicated by the interplay of task specific prompts and experiential context. At scale, bias evaluation is often based on short…

Computation and Language · Computer Science 2025-05-07 Jennifer Healey , Laurie Byrum , Md Nadeem Akhtar , Surabhi Bhargava , Moumita Sinha

Retrieval-augmented generation (RAG) appears as a promising method to alleviate the "hallucination" problem in large language models (LLMs), since it can incorporate external traceable resources for response generation. The essence of RAG…

Computation and Language · Computer Science 2024-10-16 Haosheng Qian , Yixing Fan , Ruqing Zhang , Jiafeng Guo

Since the emergence of Large Language Models (LLMs), the challenge of effectively leveraging their potential in healthcare has taken center stage. A critical barrier to using LLMs for extracting insights from unstructured clinical notes…

Artificial Intelligence · Computer Science 2024-12-04 Nader Karayanni , Aya Awwad , Chein-Lien Hsiao , Surish P Shanmugam