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Recent proprietary large language models (LLMs), such as GPT-4, have achieved a milestone in tackling diverse challenges in the biomedical domain, ranging from multiple-choice questions to long-form generations. To address challenges that…

Computation and Language · Computer Science 2024-06-19 Minbyul Jeong , Jiwoong Sohn , Mujeen Sung , Jaewoo Kang

Critical appraisal of scientific literature is an essential skill in the biomedical field. While large language models (LLMs) can offer promising support in this task, their reliability remains limited, particularly for critical reasoning…

Computation and Language · Computer Science 2026-03-05 Doria Bonzi , Alexandre Guiggi , Frédéric Béchet , Carlos Ramisch , Benoit Favre

In this paper, we propose CitaLaw, the first benchmark designed to evaluate LLMs' ability to produce legally sound responses with appropriate citations. CitaLaw features a diverse set of legal questions for both laypersons and…

Computation and Language · Computer Science 2025-02-25 Kepu Zhang , Weijie Yu , Sunhao Dai , Jun Xu

Large Language Models (LLMs) have emerged as powerful assistants for scientific writing. However, concerns remain about the quality and reliability of the generated text, including citation accuracy and faithfulness. While most recent work…

Digital Libraries · Computer Science 2026-04-14 Yee Man Choi , Xuehang Guo , Yi R. Fung , Qingyun Wang

This study applies Large Language Models (LLMs) to two foundational Electronic Health Record (EHR) data science tasks: structured data querying (using programmatic languages, Python/Pandas) and information extraction from unstructured…

Computation and Language · Computer Science 2026-01-29 Juan Jose Rubio Jan , Jack Wu , Julia Ive

With the advancement of large language models (LLMs), the biomedical domain has seen significant progress and improvement in multiple tasks such as biomedical question answering, lay language summarization of the biomedical literature,…

Information Retrieval · Computer Science 2024-12-17 Deepak Gupta , Dina Demner-Fushman , William Hersh , Steven Bedrick , Kirk Roberts

Large Language Models (LLMs) are increasingly used for clinical decision support, where hallucinations and unsafe suggestions may pose direct risks to patient safety. These risks are hard to assess: subtle clinical errors are often missed…

Computation and Language · Computer Science 2026-05-14 Yinzhu Chen , Abdine Maiga , Hossein A. Rahmani , Emine Yilmaz

We present BioRAGent, an interactive web-based retrieval-augmented generation (RAG) system for biomedical question answering. The system uses large language models (LLMs) for query expansion, snippet extraction, and answer generation while…

Computation and Language · Computer Science 2024-12-18 Samy Ateia , Udo Kruschwitz

Biomedical queries often rely on a deep understanding of specialized knowledge such as gene regulatory mechanisms and pathological processes of diseases. They require detailed analysis of complex physiological processes and effective…

Computation and Language · Computer Science 2026-02-02 Congying Liu , Xingyuan Wei , Peipei Liu , Yiqing Shen , Yanxu Mao , Tiehan Cui

Document-Level Biomedical Relation Extraction (Bio-RE) aims to identify relations between biomedical entities within extensive texts, serving as a crucial subfield of biomedical text mining. Existing Bio-RE methods struggle with…

Computation and Language · Computer Science 2025-01-10 Yufei Shang , Yanrong Guo , Shijie Hao , Richang Hong

Recent advances in large language models (LLMs) have made significant progress across multiple biomedical tasks, including biomedical question answering, lay-language summarization of the biomedical literature, and clinical note…

Information Retrieval · Computer Science 2026-03-24 Deepak Gupta , Dina Demner-Fushman , William Hersh , Steven Bedrick , Kirk Roberts

This work presents a Biomedical Literature Question Answering (Q&A) system based on a Retrieval-Augmented Generation (RAG) architecture, designed to improve access to accurate, evidence-based medical information. Addressing the shortcomings…

Computation and Language · Computer Science 2025-09-09 Mansi Garg , Lee-Chi Wang , Bhavesh Ghanchi , Sanjana Dumpala , Shreyash Kakde , Yen Chih Chen

Recent breakthroughs in Large Language Models (LLMs) have revolutionized scientific literature analysis. However, existing benchmarks fail to adequately evaluate the proficiency of LLMs in this domain, particularly in scenarios requiring…

The ability to automatically generate accurate protocols for scientific experiments would represent a major step towards the automation of science. Large Language Models (LLMs) have impressive capabilities on a wide range of tasks, such as…

Computation and Language · Computer Science 2023-10-17 Odhran O'Donoghue , Aleksandar Shtedritski , John Ginger , Ralph Abboud , Ali Essa Ghareeb , Justin Booth , Samuel G Rodriques

Large language models (LLMs) hold great promise for assisting clinical interviews due to their fluent interactive capabilities and extensive medical knowledge. However, the lack of high-quality interview dialogue data and widely accepted…

Computation and Language · Computer Science 2025-04-15 Jing Chen , Zhihua Wei , Wei Zhang , Yingying Hu , Qiong Zhang

Though current long-context large language models (LLMs) have demonstrated impressive capacities in answering user questions based on extensive text, the lack of citations in their responses makes user verification difficult, leading to…

Computation and Language · Computer Science 2024-09-11 Jiajie Zhang , Yushi Bai , Xin Lv , Wanjun Gu , Danqing Liu , Minhao Zou , Shulin Cao , Lei Hou , Yuxiao Dong , Ling Feng , Juanzi Li

Large language models (LLMs) exhibit extensive medical knowledge but are prone to hallucinations and inaccurate citations, which pose a challenge to their clinical adoption and regulatory compliance. Current methods, such as Retrieval…

Artificial intelligence (AI) and large language models (LLMs) in healthcare require advanced clinical skills (CS), yet current benchmarks fail to evaluate these comprehensively. We introduce MedQA-CS, an AI-SCE framework inspired by medical…

Artificial Intelligence · Computer Science 2026-01-21 Zonghai Yao , Zihao Zhang , Chaolong Tang , Xingyu Bian , Youxia Zhao , Zhichao Yang , Junda Wang , Huixue Zhou , Won Seok Jang , Feiyun Ouyang , Hong Yu

Question Answering (QA) is a natural language processing task that aims at obtaining relevant answers to user questions. While some progress has been made in this area, biomedical questions are still a challenge to most QA approaches, due…

Information Retrieval · Computer Science 2020-12-23 Andre Lamurias , Diana Sousa , Francisco M. Couto

Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim