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Three-dimensional molecular imaging of living cells is essential for unraveling cellular metabolism and response to therapies. However, existing volumetric methods, including fluorescence microscopy and quantitative phase imaging, either…

Cross-correlation heterodyne detectors exhibit the potential for suppression of the detection quantum noise below shot noise without use of optical squeezing for capturing weak optical signals in low frequency bands. To understand the…

Quantum Physics · Physics 2022-11-09 Sheng Feng , Kaikai Wu

Optical quantum computing, as well as quantum communication and sensing technology based on quantum correlations are in preparation. These require photodiodes for the detection of about 10^16 photons per second with close to perfect quantum…

Quantum Physics · Physics 2026-02-16 Leif Albers , Jan-Malte Michaelsen , Roman Schnabel

Employing electro-optic sampling (EOS) with ultrashort probe pulses, recent experiments showed direct measurements of quantum vacuum fields and their correlations on subcycle timescales. Here, we propose a quantum-enhanced EOS where…

Quantum Physics · Physics 2022-01-12 Stéphane Virally , Patrick Cusson , Denis V. Seletskiy

Single-molecule microscopy has become an indispensable tool for biochemical analysis. The capability of characterizing distinct properties of individual molecules without averaging has provided us with a different perspective for the…

Applied Physics · Physics 2020-05-21 Miao-Hsuan Chien , Silvan Schmid

Label-free optical absorption microscopy techniques have evolved as effective tools for non-invasive chemical specific structural, and functional imaging. Yet most modern label-free microscopy modalities target only a fraction of the…

Squeezed light can exponentially increase the signal-to-noise ratio (SNR) of dispersive qubit readout, especially using a combination of injected external squeezing (IES) and intracavity squeezing (ICS). We further investigate whether IES…

Quantum Physics · Physics 2025-07-04 Dong Xie , Chunling Xu

Is it possible to detect a feature in an image without ever looking at it? Images are known to have sparser representation in Wavelets and other similar transforms. Compressed Sensing is a technique which proposes simultaneous acquisition…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Suyash Shandilya

The investigation of novel electronic phases in low-dimensional quantum materials demands for the concurrent development of new measurement techniques that combine surface sensitivity with high spatial resolution and high measurement…

Mesoscale and Nanoscale Physics · Physics 2020-10-14 Berthold Jäck

We demonstrate a squeezing experiment exploiting the association of integrated optics and telecom technology as key features for compact, stable, and practical continuous variable quantum optics. In our setup, squeezed light is generated by…

FRET-based approaches are a unique tool for sensing the immediate surroundings and interactions of (bio)molecules. FRET imaging and FLIM (Fluorescence Lifetime Imaging Microscopy) enable the visualization of the spatial distribution of…

Cellular membrane dynamics play an important role in a variety of physiological processes. However, due to the stringent light-coupling conditions required for exciting evanescent waves, label-free mapping of cellular membrane dynamics on…

Biological Physics · Physics 2024-10-22 Chaoyang Gong , Yu-Cheng Chen

The mathematical theory of compressed sensing (CS) asserts that one can acquire signals from measurements whose rate is much lower than the total bandwidth. Whereas the CS theory is now well developed, challenges concerning hardware…

Information Theory · Computer Science 2013-07-18 Makhlad Chahid , Jerome Bobin , Hamed Shams Mousavi , Emmanuel Candes , Maxime Dahan , Vincent Studer

Squeezed-light generation in photonic integrated circuits (PICs) is essential for scalable continuous-variable (CV) quantum information processing. By suppressing quantum fluctuations below the shot-noise limit, squeezed states enable…

Quantum Physics · Physics 2025-09-15 Shuai Liu , Kailu Zhou , Yuheng Zhang , Abdulkarim Hariri , Nicholas Reynolds , Bo-Han Wu , Zheshen Zhang

Spectroscopy is a powerful tool to probe physical, chemical, and biological systems. Recent advances in microfabrication have introduced novel, intriguing mesoscopic quantum systems including superconductor-semiconductor hybrid devices and…

Mesoscale and Nanoscale Physics · Physics 2021-11-04 J. Griesmar , R. H. Rodriguez , V. Benzoni , J. -D. Pillet , J. -L. Smirr , F. Lafont , Ç. Ö. Girit

One of the most fundamental quantum states of light is squeezed vacuum, in which noise in one of the quadratures is less than the standard quantum noise limit. Significant progress has been made in the generation of optical squeezed vacuum…

Quantum Physics · Physics 2022-10-05 Rajveer Nehra , Ryoto Sekine , Luis Ledezma , Qiushi Guo , Robert M. Gray , Arkadev Roy , Alireza Marandi

The photo-kinetics of fluorescent molecules have enabled the circumvention of far-field optical diffraction-limit. Despite its enormous potential, the necessity to label the sample may adversely influence the delicate biology under…

Quantum sensors, qubits sensitive to external fields, have become powerful detectors for various small acoustic and electromagnetic fields. A major key to their success have been dynamical decoupling protocols which enhance sensitivity to…

Quantum Physics · Physics 2021-06-24 Timo Joas , Andreas M. Waeber , Georg Braunbeck , Friedemann Reinhard

Squeezed states of light are essential for emerging quantum technology in metrology and information processing. Chip-integrated photonics offers a route to scalable and efficient squeezed light generation, however, parasitic nonlinear…

Optics · Physics 2025-02-25 Alexander E. Ulanov , Bastian Ruhnke , Thibault Wildi , Tobias Herr

State-of-the-art microscopes use intense lasers that can severely disturb biological processes, function and viability. This introduces hard limits on performance that only quantum photon correlations can overcome. Here we demonstrate this…