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Efficient control of qubits plays a key role in quantum information processing. In the current work, an alternative set of differential equations are derived for an optimal quantum control of single or multiple qubits with or without…

Quantum Physics · Physics 2020-11-26 Ding Wang , Haowei Shi , Yueheng Lan

Data-driven predictive control (DPC) is a feedback control method for systems with unknown dynamics. It repeatedly optimizes a system's future trajectories based on past input-output data. We develop a numerical method that computes…

Systems and Control · Electrical Eng. & Systems 2022-11-28 Yue Yu , Ruihan Zhao , Sandeep Chinchali , Ufuk Topcu

Background: Drug-drug interactions (DDIs) refer to processes triggered by the administration of two or more drugs leading to side effects beyond those observed when drugs are administered by themselves. Due to the massive number of possible…

Quantitative Methods · Quantitative Biology 2020-12-25 Kyriakos Schwarz , Ahmed Allam , Nicolas Andres Perez Gonzalez , Michael Krauthammer

In this paper we formulate a risk-sensitive optimal control problem for continuously monitored open quantum systems modelled by quantum Langevin equations. The optimal controller is expressed in terms of a modified conditional state, which…

Quantum Physics · Physics 2016-09-08 M. R. James

A central challenge in quantum computing is to identify more computational problems for which utilization of quantum resources can offer significant speedup. Here, we propose a hybrid quantum-classical scheme to tackle the quantum optimal…

Quantum Physics · Physics 2017-04-19 Jun Li , Xiaodong Yang , Xinhua Peng , Chang-Pu Sun

We consider the problem of controlling the group behavior of a large number of dynamic systems that are constantly interacting with each other. These systems are assumed to have identical dynamics (e.g., birds flock, robot swarm) and their…

Optimization and Control · Mathematics 2021-08-18 Yongxin Chen

Molecular docking is a critical process for drug discovery and challenging due to the complexity and size of biomolecular systems, where the optimal binding configuration of a drug to a target protein is determined. Hybrid classical-quantum…

Emerging Technologies · Computer Science 2025-03-07 Christos Papalitsas , Yanfei Guan , Shreyas Waghe , Athanasios Liakos , Ioannis Balatsos , Vassilios Pantazopoulos

Pulse-modulated feedback is utilized in drug dosing to mimic sustained over a longer period of time manual discrete dose administration, the latter is in contrast with continuous drug infusion. The intermittent mode of dosing calls for a…

Dynamical Systems · Mathematics 2025-02-28 Alexander Medvedev , Anton V. Proskurnikov , Zhanybai T. Zhusubaliyev

Adverse drug-drug interactions~(DDIs) can compromise the effectiveness of concurrent drug administration, posing a significant challenge in healthcare. As the development of new drugs continues, the potential for unknown adverse effects…

Computation and Language · Computer Science 2024-03-14 Fangqi Zhu , Yongqi Zhang , Lei Chen , Bing Qin , Ruifeng Xu

Quantum optimization holds promise for addressing classically intractable combinatorial problems, yet a standardized framework for benchmarking its performance, particularly in terms of solution quality, computational speed, and scalability…

Quantum Physics · Physics 2025-03-20 Monit Sharma , Hoong Chuin Lau

Polypharmacy, defined as the use of multiple drugs together, is a standard treatment method, especially for severe and chronic diseases. However, using multiple drugs together may cause interactions between drugs. Drug-drug interaction…

Machine Learning · Computer Science 2022-07-13 Farhan Tanvir , Khaled Mohammed Saifuddin , Esra Akbas

We propose a quantum control scheme aimed at interacting systems that gives rise to highly selective coupling among their near-to-resonance constituents. Our protocol implements temporal control of the interaction strength, switching it on…

Quantum Physics · Physics 2018-08-06 J. F. Haase , Z. -Y. Wang , J. Casanova , M. B. Plenio

Quantum control is concerned with active manipulation of physical and chemical processes on the atomic and molecular scale. This work presents a perspective of progress in the field of control over quantum phenomena, tracing the evolution…

Quantum Physics · Physics 2010-07-20 Constantin Brif , Raj Chakrabarti , Herschel Rabitz

Predicting and discovering drug-drug interactions (DDIs) using machine learning has been studied extensively. However, most of the approaches have focused on text data or textual representation of the drug structures. We present the first…

Machine Learning · Computer Science 2021-03-22 Devendra Singh Dhami , Siwen Yan , Gautam Kunapuli , David Page , Sriraam Natarajan

Quantum Optimal Control (QOC) supports the advance of quantum technologies by tackling its problems at the pulse level: Numerical approaches iteratively work towards a given target by parametrising the applied time-dependent fields with a…

Quantum Physics · Physics 2025-08-05 Alice Pagano , Matthias M Müller , Tommaso Calarco , Simone Montangero , Phila Rembold

The keyboard design is a novel phase I dose-finding method that is simple and has good operating characteristics. This paper studies theoretical properties of the keyboard design, including the optimality of its decision rules, coherence in…

Methodology · Statistics 2017-12-20 Haitao Pan , Ruitao Lin , Ying Yuan

In parametric Bayesian designs of early phase cancer clinical trials with drug combinations exploring a discrete set of partially ordered doses, several authors claimed that there is no added value in including an interaction term to model…

Methodology · Statistics 2022-08-12 Mourad Tighiouart , José L. Jiménez , Marcio A. Diniz , André Rogatko

Quantum optimal control is a technique for controlling the evolution of a quantum system and has been applied to a wide range of problems in quantum physics. We study a binary quantum control optimization problem, where control decisions…

Quantum Physics · Physics 2024-10-15 Xinyu Fei , Lucas T. Brady , Jeffrey Larson , Sven Leyffer , Siqian Shen

We present a classical control mechanism for Quantum devices using Reinforcement Learning. Our strategy is applied to the Quantum Approximate Optimization Algorithm (QAOA) in order to optimize an objective function that encodes a solution…

Quantum Physics · Physics 2019-11-25 Artur Garcia-Saez , Jordi Riu

The optimal control problem for open quantum systems can be formulated as a time-dependent Lindbladian that is parameterized by a number of time-dependent control variables. Given an observable and an initial state, the goal is to tune the…

Quantum Physics · Physics 2024-05-30 Wenhao He , Tongyang Li , Xiantao Li , Zecheng Li , Chunhao Wang , Ke Wang
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