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In this article, we present an algorithm that drives the outputs of a network of agents to jointly track the solutions of time-varying optimization problems in a way that is robust to asynchrony in the agents' operations. We consider three…

Optimization and Control · Mathematics 2023-12-04 Gabriel Behrendt , Matthew Longmire , Zachary I. Bell , Matthew Hale

In variational quantum algorithms (VQAs), the most common objective is to find the minimum energy eigenstate of a given energy Hamiltonian. In this paper, we consider the general problem of finding a sufficient control Hamiltonian structure…

Understanding the quantum control landscape (QCL) is important for designing effective quantum control strategies. In this study, we analyze the QCL for a single two-level quantum system (qubit) using various control strategies. We employ…

Quantum Physics · Physics 2025-05-06 Haftu W. Fentaw , Steve Campbell , Simon Caton

Coherent feedback is a non-measurement based, hence a back-action free, method of control for quantum systems. A typical application of this control scheme is squeezing enhancement, a purely non-classical effect in quantum optics. In this…

Quantum Physics · Physics 2016-11-17 Sanae Iida , Mitsuyoshi Yukawa , Hidehiro Yonezawa , Naoki Yamamoto , Akira Furusawa

Control of large-scale networked systems often necessitates the availability of complex models for the interactions amongst the agents. However in many applications, building accurate models of agents or interactions amongst them might be…

Optimization and Control · Mathematics 2019-03-21 Siavash Alemzadeh , Mehran Mesbahi

In brain-machine interface (BMI) applications, a key challenge is the low information content and high noise level in neural signals, severely affecting stable robotic control. To address this challenge, we proposes a cooperative shared…

Robotics · Computer Science 2024-10-15 Junjie Yang , Ling Liu , Shengjie Zheng , Lang Qian , Gang Gao , Xin Chen , Xiaojian Li

Feedback control is an essential component of many modern technologies and provides a key capability for emergent quantum technologies. We extend existing approaches of direct feedback control in which the controller applies a function…

Quantum Physics · Physics 2020-12-15 Hui Chen , Hanhan Li , Felix Motzoi , Leigh S. Martin , K. Birgitta Whaley , Mohan Sarovar

Optimal control theory is a powerful tool for solving control problems in quantum mechanics, ranging from the control of chemical reactions to the implementation of gates in a quantum computer. Gradient-based optimization methods are able…

Quantum Physics · Physics 2015-10-06 Michael H. Goerz , K. Birgitta Whaley , Christiane P. Koch

We propose a novel approach to solving input- and state-constrained parametric mixed-integer optimal control problems using Differentiable Predictive Control (DPC). Our approach follows the differentiable programming paradigm by learning an…

Systems and Control · Electrical Eng. & Systems 2025-06-25 Ján Boldocký , Shahriar Dadras Javan , Martin Gulan , Martin Mönnigmann , Ján Drgoňa

Distributed control problems under some specific information constraints can be formulated as (possibly infinite dimensional) convex optimization problems. The underlying motivation of this work is to develop an understanding of the optimal…

Optimization and Control · Mathematics 2014-03-19 Takashi Tanaka , Pablo A. Parrilo

Motivation: Computational prediction of multiple-type drug-drug interaction (DDI) helps reduce unexpected side effects in poly-drug treatments. Although existing computational approaches achieve inspiring results, they ignore that the…

Machine Learning · Computer Science 2021-12-07 Hui Yu , ShiYu Zhao , JianYu Shi

Combinatorial optimization problems are one of the areas where near-term noisy quantum computers may have practical advantage against classical computers. Recently a novel feedback-based quantum optimization algorithm has been proposed by…

Quantum Physics · Physics 2025-01-13 Don Arai , Ken N. Okada , Yuichiro Nakano , Kosuke Mitarai , Keisuke Fujii

We consider the optimal experimental design problem of allocating subjects to treatment or control when subjects participate in multiple, separate controlled experiments within a short time-frame and subject covariate information is…

Methodology · Statistics 2024-12-16 William Fisher , Qiong Zhang , Lulu Kang , Xinwei Deng

Identification of optimal dose combinations in early phase dose-finding trials is challenging, due to the trade-off between precisely estimating the many parameters required to flexibly model the possibly non-monotonic dose-response…

Methodology · Statistics 2024-02-13 James Willard , Shirin Golchi , Erica E. M. Moodie , Bruno Boulanger , Bradley P. Carlin

When patients need to take medicine, particularly taking more than one kind of drug simultaneously, they should be alarmed that there possibly exists drug-drug interaction. Interaction between drugs may have a negative impact on patients or…

Computation and Language · Computer Science 2020-08-31 Siliang Tang , Qi Zhang , Tianpeng Zheng , Mengdi Zhou , Zhan Chen , Lixing Shen , Xiang Ren , Yueting Zhuang , Shiliang Pu , Fei Wu

Drug-drug interactions (DDIs) represent a critical challenge in pharmacology, often leading to adverse drug reactions with significant implications for patient safety and healthcare outcomes. While graph-based methods have achieved strong…

Machine Learning · Computer Science 2025-07-15 Mengjie Chen , Ming Zhang , Cunquan Qu

In silico drug-target interaction (DTI) prediction is an important and challenging problem in biomedical research with a huge potential benefit to the pharmaceutical industry and patients. Most existing methods for DTI prediction including…

Machine Learning · Computer Science 2019-08-22 Qingyuan Feng , Evgenia Dueva , Artem Cherkasov , Martin Ester

The need for strategies able to accurately manipulate quantum dynamics is ubiquitous in quantum control and quantum information processing. We investigate two scenarios where randomized dynamical decoupling techniques become more…

Quantum Physics · Physics 2009-11-13 Lorenza Viola , Lea F. Santos

While quantum devices rely on interactions between constituent subsystems and with their environment to operate, native interactions alone often fail to deliver targeted performance. Coherent pulsed control provides the ability to tailor…

Quantum Physics · Physics 2019-03-01 Michael F. O'Keeffe , Lior Horesh , John F. Barry , Danielle A. Braje , Isaac L. Chuang

Achieving both safety guarantees and real-time performance in cooperative vehicle coordination remains a fundamental challenge, particularly in dynamic and uncertain environments. Existing methods often suffer from insufficient uncertainty…

Robotics · Computer Science 2026-04-20 Haojie Bai , Tingting Zhang , Cong Guo , Yang Wang , Xiongwei Zhao , Hai Zhu
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