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For acute ischemic stroke (AIS) patients with large vessel occlusions, clinicians must decide if the benefit of mechanical thrombectomy (MTB) outweighs the risks and potential complications following an invasive procedure. Pre-treatment…
Abdominal aortic aneurysms (AAAs) are local dilatations in the abdominal aorta occurring due to weakening of arterial wall. The present work investigates the influence of the ratio of maximum transverse diameter to abdominal height (DHr) on…
Coronary artery stenosis, characterized by the narrowing of the lumen, significantly affects blood flow and contributes to the progression of cardiovascular diseases. This study investigates the hemodynamics of coronary artery models with…
Estimation of the initial state of turbulent channel flow from limited data is investigated using an adjoint-variational approach. The data are generated from a reference direct numerical simulation (DNS) which is sub-sampled at different…
SUMMARY This work aims at quantifying the effect of inherent uncertainties from cardiac output on the sensitivity of a human compliant arterial network response based on stochastic simulations of a reduced-order pulse wave propagation…
We propose Video-TransUNet, a deep architecture for instance segmentation in medical CT videos constructed by integrating temporal feature blending into the TransUNet deep learning framework. In particular, our approach amalgamates strong…
The aorta is the body's largest arterial vessel, serving as the primary pathway for oxygenated blood within the systemic circulation. Aortic aneurysms consistently rank among the top twenty causes of mortality in the United States. Thoracic…
Predicting the long-term success of endovascular interventions in the clinical management of cerebral aneurysms requires detailed insight into the patient-specific physiological conditions. In this work, we not only propose numerical…
We performed numerical simulations of blood flow in arteries with a variable stiffness and cross-section at rest using a finite volume method coupled with a hydrostatic reconstruction of the variables at the interface of each mesh cell. The…
The aortic valve is a three-leaflet passive structure that, driven by pressure differences between the left ventricle and the aorta, opens and closes during the heartbeat to ensure the correct stream direction and flow rate. In elderly…
Aortic stenosis (AS) is the most common valvular heart disease in developed countries. High-fidelity preclinical models can improve AS management by enabling therapeutic innovation, early diagnosis, and tailored treatment planning. However,…
Thrombosis involves processes spanning large-scale fluid flow to sub-cellular events such as platelet activation. Traditional CFD approaches often treat blood as a continuum, which can limit their ability to capture these microscale…
Postoperative complications pose a significant challenge in the healthcare industry, resulting in elevated healthcare expenses and prolonged hospital stays, and in rare instances, patient mortality. To improve patient outcomes and reduce…
Aortic valve (AV) biomechanics play a critical role in maintaining normal cardiac function. Pathological variations, particularly in bicuspid aortic valves, alter leaflet loading, increase strain, and accelerate disease progression.…
Cerebral aneurysm rupture, leading to subarachnoid hemorrhage with a high mortality rate, disproportionately affects younger populations, resulting in a significant loss of productive life years. A significant proportion of these deaths is…
Whole-body PET imaging is often hindered by respiratory motion during acquisition, causing significant degradation in the quality of reconstructed activity images. An additional challenge in PET/CT imaging arises from the respiratory phase…
Intracardiac flow patterns are shaped by the coupled motion of the cardiac chambers and heart valves and provide important information about cardiac function. However, clinical flow imaging remains limited by exam times, noise, resolution,…
We assess the suitability of Reynolds-Averaged Navier-Stokes (RANS) simulation using the Spallart-Almaras (SA) turbulence model as a closure in analysing the performance of fluidic Active Flow Control (AFC) applications. In particular, we…
This study uses a one dimensional fluid dynamics arterial network model to infer changes in hemodynamic quantities associated with pulmonary hypertension in mice. Data for this study include blood flow and pressure measurements from the…
Reentry around non-conducting ventricular scar tissue, which often causes lethal arrhythmias, is typically treated by rapid stimulation from an implantable defibrillator. However, the mechanisms of termination (success and failure) are…