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We suggest to simulate evolution of complex organisms constrained by the sole requirement of robustness in their expression patterns. This scenario is illustrated by evolving discrete logical networks with epigenetic properties. Evidence…

Statistical Mechanics · Physics 2007-05-23 Stefan Bornholdt , Kim Sneppen

This paper is concerned with the dynamical properties of deterministically modeled chemical reaction systems with mass-action kinetics. Such models are ubiquitously found in chemistry, population biology, and the burgeoning field of systems…

Dynamical Systems · Mathematics 2011-06-20 David F. Anderson

Reaction networks are commonly used to model the evolution of populations of species subject to transformations following an imposed stoichiometry. This paper focuses on the efficient characterisation of dynamical properties of Discrete…

Discrete Mathematics · Computer Science 2013-07-15 Loïc Paulevé , Gheorghe Craciun , Heinz Koeppl

We consider epidemic extinction in finite networks with broad variation in local connectivity. Generalizing the theory of large fluctuations to random networks with a given degree distribution, we are able to predict the most probable, or…

Adaptation and Self-Organizing Systems · Physics 2016-07-07 Jason Hindes , Ira B. Schwartz

We consider local bifurcations of equilibria in dynamical systems arising from chemical reaction networks with mass action kinetics. In particular, given any mass action network admitting a local bifurcation of equilibria, assuming only a…

Dynamical Systems · Mathematics 2025-05-20 Murad Banaji , Balázs Boros , Josef Hofbauer

Negative conductance elements are key to shape the input-output behavior at the terminals of a network through localized positive feedback amplification. The balance of positive and negative differential conductances creates singularities…

Optimization and Control · Mathematics 2025-04-11 Alessio Franci , Bart Besselink , Arjan van der Schaft

In this manuscript, we continue with the systematic study of the speed of extinction of continuous state branching processes in L\'evy environments under more general branching mechanisms. Here, we deal with the weakly subcritical regime…

Probability · Mathematics 2023-02-20 Natalia Cardona-Tobón , Juan Carlos Pardo

New checkable criteria for persistence of chemical reaction networks are proposed, which extend and complement those obtained by the authors in previous work. The new results allow the consideration of reaction rates which are time-varying,…

Molecular Networks · Quantitative Biology 2009-05-12 David Angeli , Patrick De Leenheer , Eduardo Sontag

Populations experience a complex interplay of continuous and discrete processes: continuous growth and interactions are punctuated by discrete reproduction events, dispersal, and external disturbances. These dynamics can be modeled by…

Populations and Evolution · Quantitative Biology 2025-09-03 Sebastian J. Schreiber

In the first part of this paper, we apply a well known discrete-to-continuum approach to a Frenkel-Kontorova-type model of an infinitely long one-dimensional chain of atoms weakly interacting with a line of fixed atoms. The rescaled model…

Mathematical Physics · Physics 2025-10-16 Dmitry Golovaty , J. Patrick Wilber

In a complex community, species continuously adapt to each other. On rare occasions, the adaptation of a species can lead to the extinction of others, and even its own. "Adaptive dynamics" is the standard mathematical framework to describe…

Populations and Evolution · Quantitative Biology 2021-07-13 Vu AT Nguyen , Dervis C Vural

Much of the theory on chemical-reaction networks (CRNs) has been developed in the ideal-solution limit, where interactions between the solutes are negligible. However, there is a large variety of phenomena in biological cells and…

Biological Physics · Physics 2022-12-09 Ander Movilla Miangolarra , Michele Castellana

A dynamical system obtains a wide variety of kinetic realizations, which is advantageous for the analysis of biochemical systems. A reaction network, derived from a dynamical system, may or may not possess some properties needed for a…

Molecular Networks · Quantitative Biology 2024-05-01 Dylan Antonio Talabis , Eduardo Mendoza

Chemical reaction networks (CRNs) are directed graphs with reactant or product complexes as vertices, and reactions as arcs. A CRN is weakly reversible if each of its connected components is strongly connected. Weakly reversible networks…

When exposed to a thermal gradient, reaction networks can convert thermal energy into the chemical selection of states that would be unfavourable at equilibrium. The kinetics of reaction paths, and thus how fast they dissipate available…

Statistical Mechanics · Physics 2021-09-01 Shiling Liang , Paolo De Los Rios , Daniel Maria Busiello

The emergence of dynamical structures in multi-agent systems is analysed. Three different mechanisms are identified, namely: (1) sensitive-dependence and convex coupling, (2) sensitive-dependence and extremal dynamics and (3) interaction…

Adaptation and Self-Organizing Systems · Physics 2007-05-23 R. Vilela Mendes

The paper deals with non-linear Poisson neuron network models with bounded memory dynamics, that can include both Hebbian learning mechanisms and refractory periods. The state of a network is described by the times elapsed since its neurons…

Probability · Mathematics 2012-06-21 Konstantin Borovkov , Geoffrey Decrouez , Matthieu Gilson

The dynamics of species' densities depend both on internal and external variables. Internal variables include frequencies of individuals exhibiting different phenotypes or living in different spatial locations. External variables include…

Populations and Evolution · Quantitative Biology 2019-03-28 Michel Benaïm , Sebastian J. Schreiber

Mass extinction is a phenomenon in the history of life on Earth when a considerable number of species go extinct over a relatively short period of time. The magnitude of extinction varies between the events, the most well known are the…

Adaptation and Self-Organizing Systems · Physics 2022-08-29 Amer Alsulami , Sergei Petrovskii

The quasi-steady state approximation and time-scale separation are commonly applied methods to simplify models of biochemical reaction networks based on ordinary differential equations (ODEs). The concentrations of the "fast" species are…

Dynamical Systems · Mathematics 2016-05-10 Meritxell Sáez , Carsten Wiuf , Elisenda Feliu
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