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Large Language Models (LLMs) have demonstrated their transformative potential across numerous disciplinary studies, reshaping the existing research methodologies and fostering interdisciplinary collaboration. However, a systematic…

Computation and Language · Computer Science 2025-07-14 Lu Xiang , Yang Zhao , Yaping Zhang , Chengqing Zong

Background: Data collected in controlled settings typically results in high-quality datasets. However, in real-world applications, the quality of data collection is often compromised. It is well established that the quality of a dataset…

Computation and Language · Computer Science 2025-02-14 Tabinda Sarwar , Antonio Jose Jimeno Yepes , Lawrence Cavedon

Effective toxic content detection relies heavily on high-quality and diverse data, which serve as the foundation for robust content moderation models. Synthetic data has become a common approach for training models across various NLP tasks.…

Computation and Language · Computer Science 2025-02-25 Zheng Hui , Zhaoxiao Guo , Hang Zhao , Juanyong Duan , Lin Ai , Yinheng Li , Julia Hirschberg , Congrui Huang

Humans often interact with large language models (LLMs) in multi-turn interaction to obtain desired answers or more information. However, most existing studies overlook the multi-turn instruction following ability of LLMs, in terms of…

Computation and Language · Computer Science 2024-05-24 Yuchong Sun , Che Liu , Kun Zhou , Jinwen Huang , Ruihua Song , Wayne Xin Zhao , Fuzheng Zhang , Di Zhang , Kun Gai

The sequential recommendation problem has attracted considerable research attention in the past few years, leading to the rise of numerous recommendation models. In this work, we explore how Large Language Models (LLMs), which are nowadays…

Information Retrieval · Computer Science 2025-01-14 Artun Boz , Wouter Zorgdrager , Zoe Kotti , Jesse Harte , Panos Louridas , Dietmar Jannach , Vassilios Karakoidas , Marios Fragkoulis

An important issue impacting healthcare is a lack of available experts. Machine learning (ML) models could resolve this by aiding in diagnosing patients. However, creating datasets large enough to train these models is expensive. We…

Computation and Language · Computer Science 2024-05-14 Chancellor R. Woolsey , Prakash Bisht , Joshua Rothman , Gondy Leroy

Large Language Models (LLMs) have shown growing potential in molecular sciences, but they often produce chemically inaccurate descriptions and struggle to recognize or justify potential errors. This raises important concerns about their…

Chemical Physics · Physics 2025-10-29 Yuyang Wu , Jinhui Ye , Shuhao Zhang , Lu Dai , Yonatan Bisk , Olexandr Isayev

Drug discovery is a critical task in biomedical natural language processing (NLP), yet explainable drug discovery remains underexplored. Meanwhile, large language models (LLMs) have shown remarkable abilities in natural language…

Computation and Language · Computer Science 2025-02-28 Kai Zhang , Rui Zhu , Shutian Ma , Jingwei Xiong , Yejin Kim , Fabricio Murai , Xiaozhong Liu

Recent studies have shown that Large Language Models (LLMs) struggle to accurately retrieve information and maintain reasoning capabilities when processing long-context inputs. To address these limitations, we propose a finetuning approach…

Machine Learning · Computer Science 2024-10-15 Zheyang Xiong , Vasilis Papageorgiou , Kangwook Lee , Dimitris Papailiopoulos

The rise of Large Language Models (LLMs) has driven progress in reasoning tasks -- from program synthesis to scientific hypothesis generation -- yet their ability to handle ranked preferences and structured algorithms in combinatorial…

Artificial Intelligence · Computer Science 2025-12-09 Hadi Hosseini , Samarth Khanna , Ronak Singh

Formal languages are an integral part of modeling and simulation. They allow the distillation of knowledge into concise simulation models amenable to automatic execution, interpretation, and analysis. However, the arguably most humanly…

Machine Learning · Computer Science 2025-10-23 Justin N. Kreikemeyer , Miłosz Jankowski , Pia Wilsdorf , Adelinde M. Uhrmacher

We present MM1.5, a new family of multimodal large language models (MLLMs) designed to enhance capabilities in text-rich image understanding, visual referring and grounding, and multi-image reasoning. Building upon the MM1 architecture,…

Background: Large language models (LLMs) such as OpenAI's GPT-4 or Google's PaLM 2 are proposed as viable diagnostic support tools or even spoken of as replacements for "curbside consults". However, even LLMs specifically trained on medical…

Artificial Intelligence · Computer Science 2024-10-21 Gioele Barabucci , Victor Shia , Eugene Chu , Benjamin Harack , Nathan Fu

In-context learning (ICL) adapts LLMs by providing demonstrations without fine-tuning the model parameters; however, it does not differentiate between demonstrations and quadratically increases the complexity of Transformer LLMs, exhausting…

Computation and Language · Computer Science 2024-11-06 Giwon Hong , Emile van Krieken , Edoardo Ponti , Nikolay Malkin , Pasquale Minervini

The introduction of large language models (LLMs) has greatly enhanced the capabilities of software agents. Instead of relying on rule-based interactions, agents can now interact in flexible ways akin to humans. However, this flexibility…

Human-Computer Interaction · Computer Science 2026-02-04 Joar Sabel , Mattias Wingren , Andreas Lundell , Sören Andersson , Sara Rosenberg , Susanne Hägglund , Linda Estman , Malin Andtfolk

Role-playing is important for Large Language Models (LLMs) to follow diverse instructions while maintaining role identity and the role's pre-defined ability limits. Existing role-playing datasets mostly contribute to controlling role style…

Computation and Language · Computer Science 2025-02-18 Junru Lu , Jiazheng Li , Guodong Shen , Lin Gui , Siyu An , Yulan He , Di Yin , Xing Sun

Large Language Models (LLMs) need to be aligned with human expectations to ensure their safety and utility in most applications. Alignment is challenging, costly, and needs to be repeated for every LLM and alignment criterion. We propose to…

Computation and Language · Computer Science 2024-10-07 Lilian Ngweta , Mayank Agarwal , Subha Maity , Alex Gittens , Yuekai Sun , Mikhail Yurochkin

Large Language Models(LLMs) have shown exceptional abilities, yet training these models can be quite challenging. There is a strong dependence on the quality of data and finding the best instruction tuning set. Further, the inherent…

Machine Learning · Computer Science 2024-06-28 Nikhil Kothari , Ravindra Nayak , Shreyas Shetty , Amey Patil , Nikesh Garera

Large language models (LLMs) effectively generate fluent text when the target output follows natural language patterns. However, structured prediction tasks confine the output format to a limited ontology, causing even very large models to…

Computation and Language · Computer Science 2023-10-19 Derek Chen , Celine Lee , Yunan Lu , Domenic Rosati , Zhou Yu

Large Language Models (LLMs) have made great strides in areas such as language processing and computer vision. Despite the emergence of diverse techniques to improve few-shot learning capacity, current LLMs fall short in handling the…

Biomolecules · Quantitative Biology 2024-05-14 Xianggen Liu , Yan Guo , Haoran Li , Jin Liu , Shudong Huang , Bowen Ke , Jiancheng Lv