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Large language models (LLMs) holds significant promise in achieving general medication recommendation systems owing to their comprehensive interpretation of clinical notes and flexibility to medication encoding. We evaluated both…

Information Retrieval · Computer Science 2025-08-05 Zihao Zhao , Chenxiao Fan , Junlong Liu , Zheng Wang , Xiangnan He , Chongming Gao , Juan Li , Fuli Feng

Large pre-trained language models (LLMs) have been shown to have significant potential in few-shot learning across various fields, even with minimal training data. However, their ability to generalize to unseen tasks in more complex fields,…

Computation and Language · Computer Science 2023-04-24 Tianhao Li , Sandesh Shetty , Advaith Kamath , Ajay Jaiswal , Xianqian Jiang , Ying Ding , Yejin Kim

The increasing volume of drug combinations in modern therapeutic regimens needs reliable methods for predicting drug-drug interactions (DDIs). While Large Language Models (LLMs) have revolutionized various domains, their potential in…

Machine Learning · Computer Science 2025-02-12 Gabriele De Vito , Filomena Ferrucci , Athanasios Angelakis

We explore the potential of Large Language Models (LLMs) to assist and potentially correct physicians in medical decision-making tasks. We evaluate several LLMs, including Meditron, Llama2, and Mistral, to analyze the ability of these…

Computation and Language · Computer Science 2024-05-07 Burcu Sayin , Pasquale Minervini , Jacopo Staiano , Andrea Passerini

In this study, the performance of various predictive models, including probabilistic baseline, CNN, LSTM, and finetuned LLMs, in forecasting merchant categories from financial transaction data have been evaluated. Utilizing datasets from…

Information Retrieval · Computer Science 2025-02-25 Halil Ibrahim Ergul , Selim Balcisoy , Burcin Bozkaya

Predicting enzymatic reactions is crucial for applications in biocatalysis, metabolic engineering, and drug discovery, yet it remains a complex and resource-intensive task. Large Language Models (LLMs) have recently demonstrated remarkable…

Artificial Intelligence · Computer Science 2025-05-12 Lorenzo Di Fruscia , Jana Marie Weber

Optimizing data mixtures is essential for unlocking the full potential of large language models (LLMs), yet identifying the optimal composition remains computationally prohibitive due to reliance on heuristic trials or expensive proxy…

Machine Learning · Computer Science 2026-01-27 Jiapeng Wang , Changxin Tian , Kunlong Chen , Ziqi Liu , Jiaxin Mao , Wayne Xin Zhao , Zhiqiang Zhang , Jun Zhou

When aligning large language models (LLMs), their performance on various tasks (such as being helpful, harmless, and honest) depends heavily on the composition of their training data. However, selecting a data mixture that achieves strong…

Machine Learning · Computer Science 2025-06-03 Nicholas E. Corrado , Julian Katz-Samuels , Adithya Devraj , Hyokun Yun , Chao Zhang , Yi Xu , Yi Pan , Bing Yin , Trishul Chilimbi

Drug combination therapy is a well-established strategy for disease treatment with better effectiveness and less safety degradation. However, identifying novel drug combinations through wet-lab experiments is resource intensive due to the…

Machine Learning · Computer Science 2023-01-18 Zhihang Hu , Qinze Yu , Yucheng Guo , Taifeng Wang , Irwin King , Xin Gao , Le Song , Yu Li

In this study, we propose a structured methodology that utilizes large language models (LLMs) in a cost-efficient and parsimonious manner, integrating the strengths of scholars and machines while offsetting their respective weaknesses. Our…

Computation and Language · Computer Science 2025-12-30 Navid Asgari , Benjamin M. Cole

The advancement of Large Language Models (LLMs) for domain applications in fields such as materials science and engineering depends on the development of fine-tuning strategies that adapt models for specialized, technical capabilities. In…

Computation and Language · Computer Science 2024-09-06 Wei Lu , Rachel K. Luu , Markus J. Buehler

The rapid evolution of artificial intelligence in drug discovery encounters challenges with generalization and extensive training, yet Large Language Models (LLMs) offer promise in reshaping interactions with complex molecular data. Our…

Biomolecules · Quantitative Biology 2024-12-20 He Cao , Zijing Liu , Xingyu Lu , Yuan Yao , Yu Li

One of the promising methods for the treatment of complex diseases such as cancer is combinational therapy. Due to the combinatorial complexity, machine learning models can be useful in this field, where significant improvements have…

Machine Learning · Computer Science 2020-01-08 Işıksu Ekşioğlu , Mehmet Tan

Instruction tuning significantly enhances the performance of large language models (LLMs) across various tasks. However, the procedure to optimizing the mixing of instruction datasets for LLM fine-tuning is still poorly understood. This…

Computation and Language · Computer Science 2024-02-20 Renxi Wang , Haonan Li , Minghao Wu , Yuxia Wang , Xudong Han , Chiyu Zhang , Timothy Baldwin

Vision-language alignment in multi-modal large language models (MLLMs) relies on supervised fine-tuning (SFT) or reinforcement learning (RL). To align multi-modal large language models (MLLMs) in the post-training stage, supervised…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Xin Jin , Siyuan Li , Siyong Jian , Kai Yu , Huan Wang

Since the rise of Large Language Models (LLMs) a couple of years ago, researchers in metaheuristics (MHs) have wondered how to use their power in a beneficial way within their algorithms. This paper introduces a novel approach that…

Artificial Intelligence · Computer Science 2025-02-13 Camilo Chacón Sartori , Christian Blum , Filippo Bistaffa , Guillem Rodríguez Corominas

Detecting life-threatening language is essential for safeguarding individuals in distress, promoting mental health and well-being, and preventing potential harm and loss of life. This paper presents an effective approach to identifying…

Computation and Language · Computer Science 2025-06-13 Thanh Thi Nguyen , Campbell Wilson , Janis Dalins

Large language models have demonstrated remarkable capabilities across various tasks, primarily attributed to the utilization of diversely sourced data. However, the impact of pretraining data composition on model performance remains poorly…

Machine Learning · Computer Science 2025-01-28 Ce Ge , Zhijian Ma , Daoyuan Chen , Yaliang Li , Bolin Ding

Large Language Models (LLMs) have demonstrated significant potential in transforming clinical applications. In this study, we investigate the efficacy of four techniques in adapting LLMs for clinical use-cases: continuous pretraining,…

In this study, we investigated the ability of the large language model (LLM) to enhance healthcare data interoperability. We leveraged the LLM to convert clinical texts into their corresponding FHIR resources. Our experiments, conducted on…

Computation and Language · Computer Science 2023-10-23 Yikuan Li , Hanyin Wang , Halid Yerebakan , Yoshihisa Shinagawa , Yuan Luo
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