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Mathematical modelling has become an established tool for studying the dynamics of biological systems. Current applications range from building models that reproduce quantitative data to identifying systems with predefined qualitative…

Molecular Networks · Quantitative Biology 2018-02-07 Carsten Conradi , Elisenda Feliu , Maya Mincheva , Carsten Wiuf

Machine learning (ML) and deep learning models are extensively used for parameter optimization and regression problems. However, not all inverse problems in ML are ``identifiable,'' indicating that model parameters may not be uniquely…

Machine Learning · Computer Science 2023-07-24 Reza Sameni

Elimination of unknowns in a system of differential equations is often required when analysing (possibly nonlinear) dynamical systems models, where only a subset of variables are observable. One such analysis, identifiability, often relies…

Algebraic Geometry · Mathematics 2022-11-28 Ruiwen Dong , Christian Goodbrake , Heather A Harrington , Gleb Pogudin

When employing mechanistic models to study biological phenomena, practical parameter identifiability is important for making accurate predictions across wide range of unseen scenarios, as well as for understanding the underlying mechanisms.…

Quantitative Methods · Quantitative Biology 2023-10-19 Yue Liu , Kevin Suh , Philip K. Maini , Daniel J. Cohen , Ruth E. Baker

The parameters of a linear compartment model are usually estimated from experimental input-output data. A problem arises when infinitely many parameter values can yield the same result; such a model is called unidentifiable. In this case,…

Combinatorics · Mathematics 2016-03-08 Jasmijn A. Baaijens , Jan Draisma

We introduce a local multifractal formalism adapted to functions, measures or distributions which display multifractal characteristics that can change with time, or location. We develop this formalism in a general framework and we work out…

Classical Analysis and ODEs · Mathematics 2012-09-19 Julien Barral , Arnaud Durand , Stéphane Jaffard , Stéphane Seuret

In this paper we outline general considerations on parameter identifiability, and introduce the notion of weak local identifiability and gradient weak local identifiability. These are based on local properties of the likelihood, in…

Statistics Theory · Mathematics 2010-02-28 Mark P. Little , Wolfgang F. Heidenreich , Guangquan Li

Extraction of local feature descriptors is a vital stage in the solution pipelines for numerous computer vision tasks. Learning-based approaches improve performance in certain tasks, but still cannot replace handcrafted features in general.…

Computer Vision and Pattern Recognition · Computer Science 2018-04-19 Kun He , Yan Lu , Stan Sclaroff

For affine stochastic differential equation with uniformly distributed time delay the local asymptotic properties of the likelihood function are studied. Local asymptotic normality, local asymptotic mixed normality, periodic local…

Statistics Theory · Mathematics 2015-09-10 János Marcell Benke , Gyula Pap

The estimation of distributed parameters in partial differential equations (PDE) from measures of the solution of the PDE may lead to under-determination problems. The choice of a parameterization is a usual way of adding a-priori…

Numerical Analysis · Mathematics 2008-01-16 Hend Ben Ameur , François Clément , Pierre Weis , Guy Chavent

The parameter space of dynamical systems arising in applications is often found to be high-dimensional and difficult to explore. We construct a fast algorithm to numerically analyze "quantitative features" of dynamical systems depending on…

Numerical Analysis · Mathematics 2008-07-15 Christian Kuehn

We introduce a logical framework for the specification and verification of component-based systems, in which finitely many component instances are active, but the bound on their number is not known. Besides specifying and verifying…

Logic in Computer Science · Computer Science 2019-08-30 Marius Bozga , Radu Iosif , Joseph Sifakis

A parameter of a mathematical model is structurally identifiable if it can be determined from noiseless experimental data. Here, we examine the identifiability properties of two important classes of linear compartmental models:…

The feasibility of uniquely estimating parameters of dynamical systems from observations is a widely discussed aspect of mathematical modelling. Several approaches have been published for analyzing identifiability. However, they are…

Methodology · Statistics 2017-08-14 Clemens Kreutz

The problem of identifying the diffusion parameter appearing in a nonlocal steady diffusion equation is considered. The identification problem is formulated as an optimal control problem having a matching functional as the objective of the…

Optimization and Control · Mathematics 2015-02-03 Marta D'Elia , Max Gunzburger

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether…

Machine Learning · Computer Science 2025-02-11 Xinshuai Dong , Ignavier Ng , Biwei Huang , Yuewen Sun , Songyao Jin , Roberto Legaspi , Peter Spirtes , Kun Zhang

This contribution deals with identification of fractional-order dynamical systems. System identification, which refers to estimation of process parameters, is a necessity in control theory. Real processes are usually of fractional order as…

Other Computer Science · Computer Science 2016-11-15 Deepyaman Maiti , Ayan Acharya , R. Janarthanan , Amit Konar

We introduce and analyze a method of learning-informed parameter identification for partial differential equations (PDEs) in an all-at-once framework. The underlying PDE model is formulated in a rather general setting with three unknowns:…

Optimization and Control · Mathematics 2023-08-25 Christian Aarset , Martin Holler , Tram Thi Ngoc Nguyen

In this paper, we consider modular local polynomials. These functions satisfy modularity while they are locally defined as polynomials outside of an exceptional set. We prove an inequality for the dimension of the space of such forms when…

Number Theory · Mathematics 2014-05-06 Kathrin Bringmann , Ben Kane

This work focuses on the identifiability of dynamical networks with partial excitation and measurement: a set of nodes are interconnected by unknown transfer functions according to a known topology, some nodes are subject to external…

Optimization and Control · Mathematics 2020-10-12 Antoine Legat , Julien M. Hendrickx