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Structural identifiability is a property of an ODE model with parameters that allows for the parameters to be determined from continuous noise-free data. This is a natural prerequisite for practical identifiability. Conducting multiple…

Algebraic Geometry · Mathematics 2021-08-18 Alexey Ovchinnikov , Anand Pillay , Gleb Pogudin , Thomas Scanlon

This paper presents a method for investigating, through an automatic procedure, the (lack of) identifiability of parametrized dynamical models. This method takes into account constraints on parameters and returns parameters whose…

Dynamical Systems · Mathematics 2016-10-11 Nathalie Verdière , Sébastien Orange

We investigate the isomorphism problem in the setting of definable sets (equivalent to sets with atoms): given two definable relational structures, are they related by a definable isomorphism? Under mild assumptions on the underlying…

Logic in Computer Science · Computer Science 2023-06-22 Khadijeh Keshvardoost , Bartek Klin , Sławomir Lasota , Joanna Ochremiak , Szymon Toruńczyk

We introduce a subclass of Lie symmetries, called parameter-state symmetries, to analyse the local structural identifiability and observability of mechanistic models consisting of state-dependent ODEs with observed outputs. These symmetries…

Dynamical Systems · Mathematics 2026-03-13 Johannes G. Borgqvist , Alexander P. Browning , Fredrik Ohlsson , Ruth E. Baker

The concept of local fractional derivative was introduced in order to be able to study the local scaling behavior of functions. However it has turned out to be much more useful. It was found that simple equations involving these operators…

Mathematical Physics · Physics 2017-08-04 Kiran M. Kolwankar

Structural identifiability is an important property of parametric ODE models. When conducting an experiment and inferring the parameter value from the time-series data, we want to know if the value is globally, locally, or non-identifiable.…

Discrete Mathematics · Computer Science 2024-06-25 Natali Gogishvili

Reliable predictions from systems biology models require knowing whether parameters can be estimated from available data, and with what certainty. Identifiability analysis reveals whether parameters are learnable in principle (structural…

We discuss the use of symmetries for analysing the structural identifiability and observability of control systems. Special emphasis is put on the role of discrete symmetries, in contrast to the more commonly studied continuous or Lie…

To comprehend complex systems with multiple states, it is imperative to reveal the identity of these states by system outputs. Nevertheless, the mathematical models describing these systems often exhibit nonlinearity so that render the…

Machine Learning · Computer Science 2023-07-04 Guangtao Zhang , Yiting Duan , Guanyu Pan , Qijing Chen , Huiyu Yang , Zhikun Zhang

Learning the unknown causal parameters of a linear structural causal model is a fundamental task in causal analysis. The task, known as the problem of identification, asks to estimate the parameters of the model from a combination of…

Artificial Intelligence · Computer Science 2024-07-18 Julian Dörfler , Benito van der Zander , Markus Bläser , Maciej Liskiewicz

This paper is devoted to integrability conditions for systems of linear difference and differential equations with difference parameters. It is shown that such a system is difference isomonodromic if and only if it is difference…

Commutative Algebra · Mathematics 2014-04-15 Alexey Ovchinnikov

Identifiability is a desirable property of a statistical model: it implies that the true model parameters may be estimated to any desired precision, given sufficient computational resources and data. We study identifiability in the context…

Machine Learning · Statistics 2020-07-09 Geoffrey Roeder , Luke Metz , Diederik P. Kingma

Identifiability of parameters is an essential property for a statistical model to be useful in most settings. However, establishing parameter identifiability for Bayesian networks with hidden variables remains challenging. In the context of…

Statistics Theory · Mathematics 2014-06-04 Elizabeth S. Allman , John A. Rhodes , Elena Stanghellini , Marco Valtorta

We discuss the solution of eigenvalue problems associated with partial differential equations that can be written in the generalized form $\m{A}x=\lambda\m{B}x$, where the matrices $\m{A}$ and/or $\m{B}$ may depend on a scalar parameter.…

Numerical Analysis · Mathematics 2020-10-12 Daniele Boffi , Francesca Gardini , Lucia Gastaldi

The discovery of particle filtering methods has enabled the use of nonlinear filtering in a wide array of applications. Unfortunately, the approximation error of particle filters typically grows exponentially in the dimension of the…

Statistics Theory · Mathematics 2015-09-10 Patrick Rebeschini , Ramon van Handel

The increasing availability of experimental data has intensified interest in calibrating stochastic models, raising fundamental questions about parameter identifiability. Structural identifiability determines whether parameters can be…

Methodology · Statistics 2026-05-14 Arianna Ceccarelli , Alexander P. Browning , Ruth E. Baker

We consider the problem of parameter estimation in dynamic systems described by ordinary differential equations. A review of the existing literature emphasizes the need for deterministic global optimization methods due to the nonconvex…

Optimization and Control · Mathematics 2025-06-16 M. Fernández de Dios , Ángel M. González-Rueda , Julio R. Banga , Julio González-Díaz , David R. Penas

While hidden class models of various types arise in many statistical applications, it is often difficult to establish the identifiability of their parameters. Focusing on models in which there is some structure of independence of some of…

Statistics Theory · Mathematics 2009-09-01 Elizabeth S. Allman , Catherine Matias , John A. Rhodes

This work focuses on the question of how identifiability of a mathematical model, that is, whether parameters can be recovered from data, is related to identifiability of its submodels. We look specifically at linear compartmental models…

Algebraic Geometry · Mathematics 2019-05-27 Elizabeth Gross , Heather A. Harrington , Nicolette Meshkat , Anne Shiu

Observability is a modelling property that describes the possibility of inferring the internal state of a system from observations of its output. A related property, structural identifiability, refers to the theoretical possibility of…

Quantitative Methods · Quantitative Biology 2018-12-12 Alejandro F. Villaverde