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Semi-supervised semantic segmentation in computational pathology remains challenging due to scarce pixel-level annotations and unreliable pseudo-label supervision. We propose UniSemAlign, a dual-modal semantic alignment framework that…

Computer Vision and Pattern Recognition · Computer Science 2026-04-13 Le-Van Thai , Tien Dat Nguyen , Hoai Nhan Pham , Lan Anh Dinh Thi , Duy-Dong Nguyen , Ngoc Lam Quang Bui

Due to the increasing workload of pathologists, the need for automation to support diagnostic tasks and quantitative biomarker evaluation is becoming more and more apparent. Foundation models have the potential to improve generalizability…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Till Nicke , Jan Raphael Schaefer , Henning Hoefener , Friedrich Feuerhake , Dorit Merhof , Fabian Kiessling , Johannes Lotz

Whole slide image (WSI) classification is a crucial problem for cancer diagnostics in clinics and hospitals. A WSI, acquired at gigapixel size, is commonly tiled into patches and processed by multiple-instance learning (MIL) models.…

Computer Vision and Pattern Recognition · Computer Science 2024-10-10 Doanh C. Bui , Jin Tae Kwak

The process of digitising histology slides involves multiple factors that can affect a whole slide image's (WSI) final appearance, including the staining protocol, scanner, and tissue type. This variability constitutes a domain shift and…

Computer Vision and Pattern Recognition · Computer Science 2024-11-26 Manahil Raza , Saad Bashir , Talha Qaiser , Nasir Rajpoot

Microscopic assessment of histopathology images is vital for accurate cancer diagnosis and treatment. Whole Slide Image (WSI) classification and captioning have become crucial tasks in computer-aided pathology. However, microscopic WSI face…

Computer Vision and Pattern Recognition · Computer Science 2025-07-10 S M Taslim Uddin Raju , Md. Milon Islam , Md Rezwanul Haque , Hamdi Altaheri , Fakhri Karray

Despite remarkable efforts been made, the classification of gigapixels whole-slide image (WSI) is severely restrained from either the constrained computing resources for the whole slides, or limited utilizing of the knowledge from different…

Computer Vision and Pattern Recognition · Computer Science 2022-07-13 Ming Feng , Kele Xu , Nanhui Wu , Weiquan Huang , Yan Bai , Changjian Wang , Huaimin Wang

Accurate analysis of histopathological images is critical for disease diagnosis and treatment planning. Whole-slide images (WSIs), which digitize tissue specimens at gigapixel resolution, are fundamental to this process but require…

Computer Vision and Pattern Recognition · Computer Science 2026-05-07 Enhui Chai , Sicheng Chen , Tianyi Zhang , Chad Wong , Kecheng Huang , Zeyu Liu , Fei Xia

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Histopathologic diagnosis relies on simultaneous integration of information from a broad range of scales, ranging from nuclear aberrations ($\approx \mathcal{O}(0.1{\mu m})$) through cellular structures ($\approx \mathcal{O}(10{\mu m})$) to…

Image and Video Processing · Electrical Eng. & Systems 2021-02-23 Rüdiger Schmitz , Frederic Madesta , Maximilian Nielsen , Jenny Krause , René Werner , Thomas Rösch

Computational analysis of whole slide images (WSIs) has seen significant research progress in recent years, with applications ranging across important diagnostic and prognostic tasks such as survival or cancer subtype prediction. Many…

Computer Vision and Pattern Recognition · Computer Science 2024-11-28 Zak Buzzard , Konstantin Hemker , Nikola Simidjievski , Mateja Jamnik

Unlike language tasks, where the output space is usually limited to a set of tokens, the output space of visual tasks is more complicated, making it difficult to build a unified visual model for various visual tasks. In this paper, we seek…

Computer Vision and Pattern Recognition · Computer Science 2023-02-15 Jia Ning , Chen Li , Zheng Zhang , Zigang Geng , Qi Dai , Kun He , Han Hu

Foundation models for computational pathology have shown great promise for specimen-level tasks and are increasingly accessible to researchers. However, specimen-level models built on these foundation models remain largely unavailable,…

Image and Video Processing · Electrical Eng. & Systems 2025-01-13 Jakub R. Kaczmarzyk , Rishul Sharma , Peter K. Koo , Joel H. Saltz

In this paper, we propose Suppression-Enhancing Mask based attention and Interactive Channel transformatiON (SEMICON) to learn binary hash codes for dealing with large-scale fine-grained image retrieval tasks. In SEMICON, we first develop a…

Computer Vision and Pattern Recognition · Computer Science 2022-09-29 Yang Shen , Xuhao Sun , Xiu-Shen Wei , Qing-Yuan Jiang , Jian Yang

Multiple instance learning (MIL) has been increasingly used in the classification of histopathology whole slide images (WSIs). However, MIL approaches for this specific classification problem still face unique challenges, particularly those…

Computer Vision and Pattern Recognition · Computer Science 2022-03-24 Hongrun Zhang , Yanda Meng , Yitian Zhao , Yihong Qiao , Xiaoyun Yang , Sarah E. Coupland , Yalin Zheng

The main alternatives nowadays to deal with sequences are Recurrent Neural Networks (RNN), Convolutional Neural Networks (CNN) architectures and the Transformer. In this context, RNN's, CNN's and Transformer have most commonly been used as…

Computation and Language · Computer Science 2019-07-02 Carlos Escolano , Marta R. Costa-jussà , Elora Lacroux , Pere-Pau Vázquez

Recent advancements in generative models have highlighted the crucial role of image tokenization in the efficient synthesis of high-resolution images. Tokenization, which transforms images into latent representations, reduces computational…

Computer Vision and Pattern Recognition · Computer Science 2024-06-12 Qihang Yu , Mark Weber , Xueqing Deng , Xiaohui Shen , Daniel Cremers , Liang-Chieh Chen

Whole slide images (WSIs) pose fundamental computational challenges due to their gigapixel resolution and the sparse distribution of informative regions. Existing approaches often treat image patches independently or reshape them in ways…

Computer Vision and Pattern Recognition · Computer Science 2026-05-19 Weiyi Wu , Xingjian Diao , Chunhui Zhang , Chongyang Gao , Xinwen Xu , Siting Li , Jiang Gui

Masked image modeling (MIM) has become a leading self-supervised learning strategy. MIMs such as Masked Autoencoder (MAE) learn strong representations by randomly masking input tokens for the encoder to process, with the decoder…

Computer Vision and Pattern Recognition · Computer Science 2024-08-27 Taekyung Kim , Sanghyuk Chun , Byeongho Heo , Dongyoon Han

Histopathology is essential for disease diagnosis and treatment decision-making. Recent advances in artificial intelligence (AI) have enabled the development of pathology foundation models that learn rich visual representations from…

In computation pathology, the pyramid structure of gigapixel Whole Slide Images (WSIs) has recently been studied for capturing various information from individual cell interactions to tissue microenvironments. This hierarchical structure is…

Computer Vision and Pattern Recognition · Computer Science 2023-09-15 Ziyu Guo , Weiqin Zhao , Shujun Wang , Lequan Yu
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