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Transformer has been widely used in histopathology whole slide image (WSI) classification for the purpose of tumor grading, prognosis analysis, etc. However, the design of token-wise self-attention and positional embedding strategy in the…

Computer Vision and Pattern Recognition · Computer Science 2022-06-28 Yushan Zheng , Jun Li , Jun Shi , Fengying Xie , Zhiguo Jiang

Language-supervised pre-training has proven to be a valuable method for extracting semantically meaningful features from images, serving as a foundational element in multimodal systems within the computer vision and medical imaging domains.…

Embodied AI models often employ off the shelf vision backbones like CLIP to encode their visual observations. Although such general purpose representations encode rich syntactic and semantic information about the scene, much of this…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Ainaz Eftekhar , Kuo-Hao Zeng , Jiafei Duan , Ali Farhadi , Ani Kembhavi , Ranjay Krishna

Histopathological whole slide image (WSI) analysis with deep learning has become a research focus in computational pathology. The current paradigm is mainly based on multiple instance learning (MIL), in which approaches with Transformer as…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongbo Chu , Qiehe Sun , Jiawen Li , Yuxuan Chen , Lizhong Zhang , Tian Guan , Anjia Han , Yonghong He

Scientific discovery pipelines typically involve complex, rigid, and time-consuming processes, from data preparation to analyzing and interpreting findings. Recent advances in AI have the potential to transform such pipelines in a way that…

Machine Learning · Computer Science 2026-02-20 Paimon Goulart , Jordan Steinhauser , Dawon Ahn , Kylene Shuler , Edward Korzus , Jia Chen , Evangelos E. Papalexakis

Labelling tissue components in histology whole slide images (WSIs) is prohibitively labour-intensive: a single slide may contain tens of thousands of structures--cells, nuclei, and other morphologically distinct objects--each requiring…

Quantitative Methods · Quantitative Biology 2026-04-13 Muhammad Haseeb Ahmad , Sharmila Rajendran , Damion Young , Jon Mason

Ensuring reliable model performance across diverse domains is a critical challenge in computational pathology. A particular source of variability in Whole-Slide Images is introduced by differences in digital scanners, thus calling for…

Computer Vision and Pattern Recognition · Computer Science 2025-09-19 Jeongun Ryu , Heon Song , Seungeun Lee , Soo Ick Cho , Jiwon Shin , Kyunghyun Paeng , Sérgio Pereira

The traditional Transformer model encounters challenges with variable-length input sequences, particularly in Hyperspectral Image Classification (HSIC), leading to efficiency and scalability concerns. To overcome this, we propose a…

Computer Vision and Pattern Recognition · Computer Science 2024-09-20 Muhammad Ahmad , Muhammad Hassaan Farooq Butt , Manuel Mazzara , Salvatore Distifano

Multiple Instance Learning (MIL) methods allow for gigapixel Whole-Slide Image (WSI) analysis with only slide-level annotations. Interpretability is crucial for safely deploying such algorithms in high-stakes medical domains. Traditional…

Computer Vision and Pattern Recognition · Computer Science 2025-01-07 Susu Sun , Leslie Tessier , Frédérique Meeuwsen , Clément Grisi , Dominique van Midden , Geert Litjens , Christian F. Baumgartner

Survival prediction based on whole slide images (WSIs) is a challenging task for patient-level multiple instance learning (MIL). Due to the vast amount of data for a patient (one or multiple gigapixels WSIs) and the irregularly shaped…

Computer Vision and Pattern Recognition · Computer Science 2023-07-03 Zhuchen Shao , Yang Chen , Hao Bian , Jian Zhang , Guojun Liu , Yongbing Zhang

Machine learning models often learn latent embedding representations that capture the domain semantics of their training data. These embedding representations are valuable for interpreting trained models, building new models, and analyzing…

Machine Learning · Computer Science 2023-06-16 Zijie J. Wang , Fred Hohman , Duen Horng Chau

Digital pathology archives increasingly contain multiple whole-slide images (WSIs) per case, capturing spatially distinct tumour regions and reflecting intrinsic morphological heterogeneity. However, most existing approaches rely on a…

Computer Vision and Pattern Recognition · Computer Science 2026-05-26 Zahra Rahimi Afzal , Wataru Uegami , Saghir Alfasly , Saba Yasir , Judy C. Boughey , Matthew P. Goetz , Krishna R. Kalari , H. R. Tizhoosh

Text-Based Person Search (TBPS) holds unique value in real-world surveillance bridging visual perception and language understanding, yet current paradigms utilizing pre-training models often fail to transfer effectively to complex…

Artificial Intelligence · Computer Science 2026-01-23 Xiangyu Wang , Zhixin Lv , Yongjiao Sun , Anrui Han , Ye Yuan , Hangxu Ji

Internal representations within deep neural architectures encode high-dimensional abstractions of linguistic structures, yet they often exhibit inefficiencies in feature distribution, limiting expressiveness and adaptability. Contextual…

Computation and Language · Computer Science 2025-03-27 Alistair Wren , Beatrice Loxley , Hamish Cadwallader , Simon Beckwith , Fabian Pargeter , James Blades

In the field of computational pathology, the use of decision support systems powered by state-of-the-art deep learning solutions has been hampered by the lack of large labeled datasets. Until recently, studies relied on datasets in the…

Computer Vision and Pattern Recognition · Computer Science 2018-10-01 Gabriele Campanella , Vitor Werneck Krauss Silva , Thomas J. Fuchs

Neural networks encode inputs as high-dimensional vectors, known as representations, that capture how models process data by encoding task-relevant structure and semantics. Representation alignment refers to the degree to which different…

Computational Geometry · Computer Science 2026-05-26 Xinyuan Yan , Rita Sevastjanova , Mennatallah El-Assady , Bei Wang

Deep-learning techniques have been used widely to alleviate the labour-intensive and time-consuming manual annotation required for pixel-level tissue characterization. Our previous study introduced an efficient single dynamic network -…

Image and Video Processing · Electrical Eng. & Systems 2023-05-25 Haoju Leng , Ruining Deng , Zuhayr Asad , R. Michael Womick , Haichun Yang , Lipeng Wan , Yuankai Huo

Gathering histopathology slides from over 100 publicly available cohorts, we compile a diverse dataset of 460 million pathology tiles covering more than 30 cancer sites. Using this dataset, we train a large self-supervised vision…

Image and Video Processing · Electrical Eng. & Systems 2024-09-17 Alexandre Filiot , Paul Jacob , Alice Mac Kain , Charlie Saillard

In this work, we propose aligning pretrained visual encoders to serve as tokenizers for latent diffusion models in image generation. Unlike training a variational autoencoder (VAE) from scratch, which primarily emphasizes low-level details,…

Computer Vision and Pattern Recognition · Computer Science 2026-02-24 Bowei Chen , Sai Bi , Hao Tan , He Zhang , Tianyuan Zhang , Zhengqi Li , Yuanjun Xiong , Jianming Zhang , Kai Zhang

CLIP embeddings have demonstrated remarkable performance across a wide range of multimodal applications. However, these high-dimensional, dense vector representations are not easily interpretable, limiting our understanding of the rich…

Machine Learning · Computer Science 2024-11-05 Usha Bhalla , Alex Oesterling , Suraj Srinivas , Flavio P. Calmon , Himabindu Lakkaraju
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