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Introducing interpretability and reasoning into Multiple Instance Learning (MIL) methods for Whole Slide Image (WSI) analysis is challenging, given the complexity of gigapixel slides. Traditionally, MIL interpretability is limited to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Saarthak Kapse , Pushpak Pati , Srijan Das , Jingwei Zhang , Chao Chen , Maria Vakalopoulou , Joel Saltz , Dimitris Samaras , Rajarsi R. Gupta , Prateek Prasanna

Visual representation learning has been a cornerstone in computer vision, involving typical forms such as visual embeddings, structural symbols, and text-based representations. Despite the success of CLIP-type visual embeddings, they often…

Computer Vision and Pattern Recognition · Computer Science 2024-06-18 Yiwu Zhong , Zi-Yuan Hu , Michael R. Lyu , Liwei Wang

Text Image Machine Translation (TIMT) aims to translate texts embedded within an image into another language. Current TIMT studies primarily focus on providing translations for all the text within an image, while neglecting to provide…

Computer Vision and Pattern Recognition · Computer Science 2025-09-17 Wanru Zhuang , Wenbo Li , Zhibin Lan , Xu Han , Peng Li , Jinsong Su

Whole-slide image analysis via the means of computational pathology often relies on processing tessellated gigapixel images with only slide-level labels available. Applying multiple instance learning-based methods or transformer models is…

Computer Vision and Pattern Recognition · Computer Science 2023-10-20 Joshua Butke , Noriaki Hashimoto , Ichiro Takeuchi , Hiroaki Miyoshi , Koichi Ohshima , Jun Sakuma

Whole Slide Imaging (WSI) is a cornerstone of digital pathology, offering detailed insights critical for diagnosis and research. Yet, the gigapixel size of WSIs imposes significant computational challenges, limiting their practical utility.…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Ravi Kant Gupta , Shounak Das , Amit Sethi

Representation learning of pathology whole-slide images (WSIs) has been has primarily relied on weak supervision with Multiple Instance Learning (MIL). However, the slide representations resulting from this approach are highly tailored to…

Computer Vision and Pattern Recognition · Computer Science 2024-05-21 Andrew H. Song , Richard J. Chen , Tong Ding , Drew F. K. Williamson , Guillaume Jaume , Faisal Mahmood

Recent rapid progress in the field of computational pathology has been enabled by foundation models. These models are beginning to move beyond encoding image patches towards whole-slide understanding but their clinical utility remains…

Large Pre-trained Transformers exhibit an intriguing capacity for in-context learning. Without gradient updates, these models can rapidly construct new predictors from demonstrations presented in the inputs. Recent works promote this…

Computer Vision and Pattern Recognition · Computer Science 2023-08-22 Yi-Syuan Chen , Yun-Zhu Song , Cheng Yu Yeo , Bei Liu , Jianlong Fu , Hong-Han Shuai

In multi-modal biomedical research, integrating high-dimensional genomic data with clinical baselines is essential for precision medicine. However, standard deep neural network approaches often entangle these modalities, obscuring the…

Applications · Statistics 2026-05-26 Jiarui Zhang , Shuoxun Xu , Jiasheng Shi , Xinzhou Guo

With the development of digital imaging in medical microscopy, artificial intelligent-based analysis of pathological whole slide images (WSIs) provides a powerful tool for cancer diagnosis. Limited by the expensive cost of pixel-level…

Computer Vision and Pattern Recognition · Computer Science 2024-11-19 Jiawen Li , Qiehe Sun , Renao Yan , Yizhi Wang , Yuqiu Fu , Yani Wei , Tian Guan , Huijuan Shi , Yonghonghe He , Anjia Han

Encoder transformer models compress information from all tokens in a sequence into a single [CLS] token to represent global context. This approach risks diluting fine-grained or hierarchical features, leading to information loss in…

Computation and Language · Computer Science 2025-09-23 Asif Shahriar , Rifat Shahriyar , M Saifur Rahman

Tissue semantic segmentation is one of the key tasks in computational pathology. To avoid the expensive and laborious acquisition of pixel-level annotations, a wide range of studies attempt to adopt the class activation map (CAM), a…

Computer Vision and Pattern Recognition · Computer Science 2024-12-31 Zijie Fang , Yifeng Wang , Peizhang Xie , Zhi Wang , Yongbing Zhang

While Vision-Language Models (VLMs) have achieved notable progress in computational pathology (CPath), the gigapixel scale and spatial heterogeneity of Whole Slide Images (WSIs) continue to pose challenges for multimodal understanding.…

Computer Vision and Pattern Recognition · Computer Science 2025-12-22 Fengchun Liu , Songhan Jiang , Linghan Cai , Ziyue Wang , Yongbing Zhang

The organization of latent token representations plays a crucial role in determining the stability, generalization, and contextual consistency of language models, yet conventional approaches to embedding refinement often rely on parameter…

Computation and Language · Computer Science 2025-03-26 Meiquan Dong , Haoran Liu , Yan Huang , Zixuan Feng , Jianhong Tang , Ruoxi Wang

Existing WSI analysis methods lie on the consensus that histopathological characteristics of tumors are significant guidance for cancer diagnostics. Particularly, as the evolution of cancers is a continuous process, the correlations and…

Computer Vision and Pattern Recognition · Computer Science 2024-07-22 Tong Shu , Jun Shi , Dongdong Sun , Zhiguo Jiang , Yushan Zheng

Foundation models have revolutionized tasks in computer vision and natural language processing. However, in the realm of tabular data, tree-based models like XGBoost continue to dominate. TabPFN, a transformer model tailored for tabular…

Machine Learning · Computer Science 2024-02-13 Junwei Ma , Valentin Thomas , Guangwei Yu , Anthony Caterini

A Whole Slide Image (WSI) is a high-resolution digital image created by scanning an entire glass slide containing a biological specimen, such as tissue sections or cell samples, at multiple magnifications. These images are digitally…

Pretrained encoders for mathematical texts have achieved significant improvements on various tasks such as formula classification and information retrieval. Yet they remain limited in representing and capturing student strategies for entire…

Computers and Society · Computer Science 2026-04-13 Siddhartha Pradhan , Ethan Prihar , Erin Ottmar

Whole Slide Images (WSIs) exhibit hierarchical structure, where diagnostic information emerges from cellular morphology, regional tissue organization, and global context. Existing Computational Pathology (CPath) Multimodal Large Language…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Basit Alawode , Arif Mahmood , Muaz Khalifa Al-Radi , Shahad Albastaki , Asim Khan , Muhammad Bilal , Moshira Ali Abdalla , Mohammed Bennamoun , Sajid Javed

Artificial intelligence (AI) has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images (WSIs). However, current methods are computationally inefficient, processing thousands of redundant…