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The controlled modulation of an optical wavefront is required for aberration correction, digital phase conjugation or patterned photostimulation. For most of these applications it is desirable to control the wavefront modulation at the…
In water monitoring, environmental analysis, cell culture stability, and biomedical applications, precise pH control is demanded. Traditional methods like pH strips and meters have limitations: pH strips lack precision, while…
The emergence of high repetition-rate X-ray free-electron lasers (XFELs) powered by superconducting accelerator technology enables the measurement of significantly more experimental data per day than was previously possible. The European…
Two-photon excitation (TPE) proceeds via a "virtual" pathway, which depends on the accessibility of one or more intermediate states, and, in the case of non-centrosymmetric molecules, an additional "dipole" pathway involving the…
Random scattering is usually viewed as a serious nuisance in optical imaging, and needs to be prevented in the conventional imaging scheme based on single-photon interference. Here we proposed a two-photon imaging scheme with the widely…
We propose and experimentally demonstrate an optical pulse sampling method for photonic blind source separation. The photonic system processes and separates wideband signals based on the statistical information of the mixed signals and thus…
Fast, volumetric imaging over large scales has been a long-standing goal in biological microscopy. Scanning techniques such as fluorescence confocal microscopy can acquire 2D images at high resolution and high speed, but extending the…
Low-light optical imaging refers to the use of cameras to capture images with minimal photon flux. This area has broad application to diverse fields, including optical microscopy for biological studies. In such studies, it is important to…
Microwaves generated by optical techniques have demonstrated unprecedentedly low noise and hold significance in various applications such as communication, radar, instrumentation, and metrology. To date, the purest microwave signals are…
The combination of different imaging modalities into single imaging platforms has a strong potential in biomedical sciences since it permits the analysis of complementary properties of the target sample. Here, we report on an extremely…
Non-degenerate 2-photon excitation (ND-2PE) of a fluorophore with two laser beams of different photon energies offers an independent degree of freedom in tuning of the photon flux for each beam. This feature takes advantage of the infrared…
We report two-photon lensless imaging through a novel golden spiral multicore fiber. This unique layout optimizes the sidelobe levels, field of view, cross-talk, group delay and mode density to achieve a sidelobe contrast of atleast 10.9…
Label-free nonlinear optical microscopy has become a powerful tool for biomedical research. However, the possible photodamage risk hinder further clinical applications. To reduce these adverse effects, we constructed a new platform of…
Fast-responding detector arrays are commonly used for imaging rapidly-changing scenes. Besides array detectors, a single-pixel detector combined with a broadband optical spectrum can also be used for rapid imaging by mapping the spectrum…
An interferometric fluorescent microscope and a novel theoretic image reconstruction approach were developed and used to obtain super-resolution images of live biological samples and to enable dynamic real time tracking. The tracking…
In light-sheet fluorescence microscopy (LSFM), the axial resolution is governed by the illumination beam profile, motivating the development of advanced beam-shaping techniques to enhance imaging performance. Two-photon LSFM (2P-LSFM), in…
Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1. However, MPM is generally based on single-point laser-focus scanning, which…
Intraoperative optical imaging is essential for surgical precision and patient safety, but current systems present anatomical and fluorescence information separately, causing delays and increasing cognitive load. A unified system for…
Gigahertz (GHz) imaging using hard X-rays ($\gtrsim$ 10 keV) can be useful to high-temperature plasma experiments, as well as research using coherent photons from synchrotron radiation and X-ray free electron lasers. GHz framing rate can be…
Optical approaches to fluorescent, spectroscopic, and morphological imaging have made exceptional advances in the last decade. Super-resolution imaging and wide-field multiphoton imaging are now underpinning major advances across the…