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We numerically analyze the use of intense entangled twin beams for ultra-sensitive spectroscopic measurements in chemical and biological systems. The examined scheme makes use of intense frequency-modulated (chirped) entangled beams to…

Quantum Physics · Physics 2018-05-16 Jiří Svozilík , Jan Peřina , Roberto de J. León-Montiel

Synchronising ultra-short (~fs) and focussed laser pulses is a particularly difficult task, as this timescale lies orders of magnitude below the typical range of fast electronic devices. Here we present an optical technique that allows for…

Dispersion-based photonics-assisted microwave measurement systems provide immense potential for real-time analysis of wideband and dynamic signals. However, they face two critical challenges: a difficulty in achieving high frequency…

Optics · Physics 2026-02-13 Chi Jiang , Taixia Shi , Hang Yang , Lei Gao , Xianxin Zhang , Yiqing Liu , Yang Chen

Lightsheet microscopy is a powerful 3-D imaging technique that addresses limitations of traditional optical and confocal microscopy but suffers from a low penetration depth and reduced image quality at greater depths. Multiview lightsheet…

Image and Video Processing · Electrical Eng. & Systems 2025-03-21 Marek Wodzinski , Henning Müller

Selective plane illumination microscopy (SPIM), also known as light sheet fluorescence microscopy, provides high specificity through fluorescence labeling. However, it lacks complementary structural information from the surrounding context,…

Optics · Physics 2024-12-19 Rui Ma , Olga Lyraki , Daniel Wehner , Jochen Guck

Fluorescence microscopes can record the dynamics of living cells with high spatio-temporal resolution in a single plane. However, monitoring rapid and dim fluorescence fluctuations, e.g induced by neuronal activity in the brain, remains…

Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing…

We demonstrate a significant resolution enhancement beyond the conventional limit in multiphoton microscopy (MPM) using saturated excitation of fluorescence. Our technique achieves super-resolved imaging by temporally modulating the…

Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique in biomedical research that uses the fluorophore decay rate to provide additional contrast in fluorescence microscopy. However, at present, the calculation, analysis,…

Image and Video Processing · Electrical Eng. & Systems 2021-06-09 Varun Mannam , Yide Zhang , Xiaotong Yuan , Cara Ravasio , Scott S. Howard

In this letter we report for the first time the possibility of visualizing an atomizing spray by simultaneously recording X-ray absorption and 2- photon laser-induced fluorescence imaging. This unique illumination/detection scheme was made…

Microfluidic systems with integrated sensors are ideal platforms to study and emulate processes such as complex multiphase flow and reactive transport in porous media, numerical modeling of bulk systems in medicine, and in engineering.…

We propose and demonstrate an interferometric scheme for measuring the two-dimensional two-point cross-spectral density function in a two-shot manner. Our scheme comprises a Michelson interferometer with a converging lens in one of the arms…

Instrumentation and Detectors · Physics 2018-08-01 Abhinandan Bhattacharjee , Shaurya Aarav , Anand K. Jha

The absolute calibration and characterization of the Multiband Imaging Photometer for Spitzer (MIPS) 70 micron coarse- and fine-scale imaging modes are presented based on over 2.5 years of observations. Accurate photometry (especially for…

We investigate a method to produce photon pairs by four-wave mixing in photonic crystal fibers (PCFs). By controlling the wavelength of the pump light, which determines the phase matching condition for four-wave mixing, we can obtain a…

Quantum Physics · Physics 2011-06-16 Toshihiro Nakanishi , Kazuo Sakemi , Hirokazu Kobayashi , Kazuhiko Sugiyama , Masao Kitano

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM's utility. Recently, it has been shown that…

Multimode fibres are becoming increasingly attractive in optical endoscopy as they promise to enable unparalleled miniaturisation, spatial resolution and cost as compared to conventional fibre bundle-based counterpart. However, achieving…

Medical Physics · Physics 2024-06-05 Tianrui Zhao , Michelle T. Ma , Sebastien Ourselin , Tom Vercauteren , Wenfeng Xia

We develop a theoretical analysis of four-wave mixing used to generate photon pairs useful for quantum information processing. The analysis applies to a single mode microstructured fibre pumped by an ultra-short coherent pulse in the normal…

Quantum Physics · Physics 2009-11-13 O. Alibart , J. Fulconis , G. K. L. Wong , S. G. Murdoch , W. J. Wadsworth , J. G. Rarity

Birefringence, an inherent characteristic of optically anisotropic materials, is widely utilized in various imaging applications ranging from material characterizations to clinical diagnosis. Polarized light microscopy enables…

Novel imaging techniques utilizing nondegenerate, correlated photon pairs sparked intense interest during the last couple of years among scientists of the quantum optics community and beyond. It is a key property of such "ghost imaging" or…

Applied Physics · Physics 2020-06-26 Andras Buzas , Elmar K. Wolff , Mihaly G. Benedict , Pal Ormos , Andras Der

Microscopes face a trade-off between spatial resolution, field-of-view, and frame rate -- improving one of these properties typically requires sacrificing the others, due to the limited spatiotemporal throughput of the sensor. To overcome…

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