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In this article, we design a novel Transcranial Electrical Stimulator for medical applications, which is very cheap and can produce the desired signals very accurately. Our fabricated stimulator generates all current signals related to…

Signal Processing · Electrical Eng. & Systems 2020-09-10 HoseinAli Jafari , Mohammad Bagher Heydari , Niloofar Jafari , Hamid Mirhosseini

Neurofeedback is a promising approach for non-invasive modulation of human brain activity with applications for treatment of mental disorders and enhancement of brain performance. Neurofeedback techniques are commonly based on either…

Medical Physics · Physics 2013-12-10 Vadim Zotev , Raquel Phillips , Han Yuan , Masaya Misaki , Jerzy Bodurka

Precise control of neural activity -- modulating target neurons deep in the brain while leaving nearby neurons unaffected -- is an outstanding challenge in neuroscience, generally approached using invasive techniques. This study…

Neurons and Cognition · Quantitative Biology 2025-06-17 Guy Gaziv , Sarah Goulding , Ani Ayvazian-Hancock , Yoon Bai , James J. DiCarlo

Neuronal excitability is known to be affected by transcranial electrical stimulation. However, due to the existence of both excitatory and inhibitory neurons in the cortex, the mechanism of neuronal excitability shift is still not clear.…

Neurons and Cognition · Quantitative Biology 2019-08-23 Jiahui Wang , Hao Wang , Xin Yuan Thow , Nitish V. Thakor

Transcranial magnetic stimulation (TMS) is widely used for understanding brain function in neurologically intact subjects and for the treatment of various disorders. However, the precise neurophysiological effects of TMS at the site of…

Neurons and Cognition · Quantitative Biology 2021-10-27 Farshad Rafiei , Dobromir Rahnev

The temporal shape of a pulse in transcranial magnetic stimulation (TMS) influences which neuron populations are activated preferentially as well as the strength and even direction of neuromodulation effects. Furthermore, various pulse…

Medical Physics · Physics 2022-02-15 Z. Li , J. Zhang , A. V. Peterchev , S. M. Goetz

Localizing neuronal activity in the brain, both in time and in space, is a central challenge to advance the understanding of brain function. Because of the inability of any single neuroimaging techniques to cover all aspects at once, there…

Neurons and Cognition · Quantitative Biology 2013-07-09 Yaroslav O. Halchenko , Michael Hanke , James V. Haxby , Stephen Jose Hanson , Christoph S. Herrmann

The ability to modulate brain states using targeted stimulation is increasingly being employed to treat neurological disorders and to enhance human performance. Despite the growing interest in brain stimulation as a form of neuromodulation,…

Neurons and Cognition · Quantitative Biology 2016-01-07 Sarah Feldt Muldoon , Fabio Pasqualetti , Shi Gu , Matthew Cieslak , Scott T. Grafton , Jean M. Vettel , Danielle S. Bassett

Whether transcranial direct current stimulation (tDCS) benefits stroke rehabilitation remains unclear. To investigate how tDCS reorganizes brain circuitry, nineteen post-stroke patients underwent rehabilitation sessions with bi-hemispheric…

The reconstruction of brain neural network connections occurs not only during the infancy and early childhood stages of brain development, but also in patients with cognitive impairment in middle and old age under the therapy with…

Neurons and Cognition · Quantitative Biology 2024-03-12 Xuan Zhang , Duoyu Feng , Djibrina Barry , Jiajia Li

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here, we report optically-generated…

Neurons and Cognition · Quantitative Biology 2022-11-07 Yueming Li , Ying Jiang , Lu Lan , Xiaowei Ge , Ran Cheng , Yuewei Zhan , Guo Chen , Linli Shi , Runyu Wang , Nan Zheng , Chen Yang , Ji-Xin Cheng

Deep brain stimulation (DBS) has the potential to improve the quality of life of people with a variety of neurological diseases. A key challenge in DBS is in the placement of a stimulation electrode in the anatomical location that maximizes…

Computer Vision and Pattern Recognition · Computer Science 2018-11-27 Camilo Bermudez , William Rodriguez , Yuankai Huo , Allison E. Hainline , Rui Li , Robert Shults , Pierre D. DHaese , Peter E. Konrad , Benoit M. Dawant , Bennett A. Landman

Non-invasive stimulation of small, variably shaped brain sub-regions is crucial for advancing our understanding of brain functions. Current ultrasound neuromodulation faces two significant trade-offs when targeting brain sub-regions:…

Neurons and Cognition · Quantitative Biology 2025-07-09 Yueming Li , Guo Chen , Tiago R. Oliveira , Nick Todd , Yong-Zhi Zhang , Carolyn Marar , Nan Zheng , Lu Lan , Nathan McDannold , Ji-Xin Cheng , Chen Yang

Objective: Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique used to generate conduction currents in the head and disrupt brain functions. To rapidly evaluate the tDCS-induced current density in…

Quantitative Methods · Quantitative Biology 2022-10-07 Xiaofan Jia , Sadeed Bin Sayed , Nahian Ibn Hasan , Luis J. Gomez , Guang-Bin Huang , Abdulkadir C. Yucel

In individuals afflicted with conditions such as paralysis, the implementation of Brain-Computer-Interface (BCI) has begun to significantly impact their quality of life. Furthermore, even in healthy individuals, the anticipated advantages…

Neurons and Cognition · Quantitative Biology 2024-03-01 Masaru Kuwabara , Ryota Kanai

Background: The use of near-infrared lasers for transcranial photobiomodulation (tPBM) offers a non-invasive method for influencing brain activity and is beneficial for various neurological conditions. Objective: To investigate the safety…

Neurons and Cognition · Quantitative Biology 2024-07-16 Zhilin Li , Yongheng Zhao , Yiqing Hu , Yang Li , Keyao Zhang , Zhibing Gao , Lirou Tan , Hanli Liu , Xiaoli Li , Aihua Cao , Zaixu Cui , Chenguang Zhao

Deep brain stimulation (DBS) is an effective therapy as an alternative to pharmaceutical treatments for Parkinson's disease (PD). Aside from factors such as instrumentation, treatment plans, and surgical protocols, the success of the…

Image and Video Processing · Electrical Eng. & Systems 2024-10-30 Yiming Xiao , Jonathan C. Lau , Dimuthu Hemachandra , Greydon Gilmore , Ali R. Khan , Terry M. Peters

In several diagnosis and therapy procedures based on electrostimulation effect, the internal physical quantity related to the stimulation is the induced electric field. To estimate the induced electric field in an individual human model,…

Medical Physics · Physics 2021-02-03 Essam A. Rashed , Jose Gomez-Tames , Akimasa Hirata

In the emerging research field of bioelectronic medicine, it has been indicated that neuromodulation of the Vagus Nerve (VN) has the potential to treat various conditions such as epilepsy, depression, and autoimmune diseases. In order to…

Neuronavigation is widely used in biomedical research and interventions to guide the precise placement of instruments around the head to support procedures such as transcranial magnetic stimulation. Traditional systems, however, rely on…

Computer Vision and Pattern Recognition · Computer Science 2026-05-12 Ziye Xie , Oded Schlesinger , Raj Kundu , Jessica Y. Choi , Pablo Iturralde , Dennis A. Turner , Stefan M. Goetz , Guillermo Sapiro , Angel V. Peterchev , J. Matias Di Martino