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Fluorescence microscopy is essential in biological and medical research, providing critical insights into cellular structures. However, limited by optical diffraction and background noise, a substantial amount of hidden information is still…

Biological Physics · Physics 2026-04-14 Xiaofeng Zhang , Yongsheng Huang , Jielong Yang , Zhili Wang , Si Chen , Linbo Liu , Xin Ge

We present a physics-informed deep learning framework to address common limitations in Confocal Laser Scanning Microscopy (CLSM), such as diffraction limited resolution, noise, and undersampling due to low laser power conditions. The…

Materials Science · Physics 2025-01-27 Zaheer Ahmad , Junaid Shabeer , Usman Saleem , Tahir Qadeer , Abdul Sami , Zahira El Khalidi , Saad Mehmood

Recently, much progress has been made in unsupervised denoising learning. However, existing methods more or less rely on some assumptions on the signal and/or degradation model, which limits their practical performance. How to construct an…

Image and Video Processing · Electrical Eng. & Systems 2022-04-29 Wei Wang , Fei Wen , Zeyu Yan , Peilin Liu

MetaDL Challenge 2020 focused on image classification tasks in few-shot settings. This paper describes second best submission in the competition. Our meta learning approach modifies the distribution of classes in a latent space produced by…

Machine Learning · Computer Science 2021-02-12 Tomáš Chobola , Daniel Vašata , Pavel Kordík

Super-resolution Structured Illumination Microscopy (SR-SIM) enables fluorescence microscopy beyond the diffraction limit at high frame rates. Compared to other super-resolution microscopy techniques, the low photon fluence used in SR-SIM…

The lensless endoscope (LE) is a promising device to acquire in vivo images at a cellular scale. The tiny size of the probe enables a deep exploration of the tissues. Lensless endoscopy with a multicore fiber (MCF) commonly uses a spatial…

There is a neglected fact in the traditional machine learning methods that the data sampling can actually lead to the solution sampling. We consider this observation to be important because having the solution sampling available makes the…

Computer Vision and Pattern Recognition · Computer Science 2017-06-06 Shangzhen Luan , Baochang Zhang , Jungong Han , Chen Chen , Ling Shao , Alessandro Perina , Linlin Shen

Machine learning (ML) techniques have recently enabled enormous gains in sensitivity to new phenomena across the sciences. In particle physics, much of this progress has relied on excellent simulations of a wide range of physical processes.…

Data Analysis, Statistics and Probability · Physics 2025-10-20 Malte Algren , Tobias Golling , Francesco Armando Di Bello , Christopher Pollard

Molecular dynamics simulations are a cornerstone in science, allowing to investigate from the system's thermodynamics to analyse intricate molecular interactions. In general, to create extended molecular trajectories can be a…

Computational Physics · Physics 2022-06-22 Ludwig Winkler , Klaus-Robert Müller , Huziel E. Sauceda

Multiple Kernel Learning, or MKL, extends (kernelized) SVM by attempting to learn not only a classifier/regressor but also the best kernel for the training task, usually from a combination of existing kernel functions. Most MKL methods seek…

Machine Learning · Computer Science 2016-03-07 John Moeller , Sarathkrishna Swaminathan , Suresh Venkatasubramanian

We recast the forward pass of a multilayered convolutional neural network (CNN) as the solution to the problem of sparse least squares migration (LSM). The CNN filters and feature maps are shown to be analogous, but not equivalent, to the…

Geophysics · Physics 2020-05-26 Zhaolun Liu , Yuqing Chen , Gerard Schuster

A scanning tunneling microscope (STM) can do more than atomic imaging and manipulation. Its tunneling current can also be used for the excitation of light, converting electron energy to photon energy. STM based single-molecule…

Optics · Physics 2019-01-01 Yao Zhang , Yang Zhang , Zhenchao Dong

In machine learning, the cost function is crucial because it measures how good or bad a system is. In image classification, well-known networks only consider modifying the network structures and applying cross-entropy loss at the end of the…

Computer Vision and Pattern Recognition · Computer Science 2019-06-18 Trung Dung Do , Cheng-Bin Jin , Hakil Kim , Van Huan Nguyen

Self-supervised learning (SSL) methods targeting scene images have seen a rapid growth recently, and they mostly rely on either a dedicated dense matching mechanism or a costly unsupervised object discovery module. This paper shows that…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Ke Zhu , Minghao Fu , Jianxin Wu

Optical super-resolution microscopy is a key technology for structural biology that offers high imaging contrast and live-cell compatibility. Minimal (fluorescence) photons flux microscopy, or MINFLUX, is an emerging super-resolution…

Optics · Physics 2025-08-29 Lukas Scheiderer , Zach Marin , Jonas Ries

Traditional supervised 3D medical image segmentation models need voxel-level annotations, which require huge human effort, time, and cost. Semi-supervised learning (SSL) addresses this limitation of supervised learning by facilitating…

Image and Video Processing · Electrical Eng. & Systems 2024-07-09 Suruchi Kumari , Aryan Das , Swalpa Kumar Roy , Indu Joshi , Pravendra Singh

Correlation filters are special classifiers designed for shift-invariant object recognition, which are robust to pattern distortions. The recent literature shows that combining a set of sub-filters trained based on a single or a small group…

Computer Vision and Pattern Recognition · Computer Science 2018-02-14 Baochang Zhang , Shangzhen Luan , Chen Chen , Jungong Han , Wei Wang , Alessandro Perina , Ling Shao

Humans have a unique ability to learn new representations from just a handful of examples with little to no supervision. Deep learning models, however, require an abundance of data and supervision to perform at a satisfactory level.…

Computer Vision and Pattern Recognition · Computer Science 2022-10-13 Ojas Kishorkumar Shirekar , Anuj Singh , Hadi Jamali-Rad

In Ultrasound Localization Microscopy (ULM), achieving high-resolution images relies on the precise localization of contrast agent particles across a series of beamformed frames. However, our study uncovers an enormous potential: The…

Computational Geometry · Computer Science 2024-04-09 Christopher Hahne , Georges Chabouh , Arthur Chavignon , Olivier Couture , Raphael Sznitman

In this paper, we introduce a novel self-supervised learning (SSL) loss for image representation learning. There is a growing belief that generalization in deep neural networks is linked to their ability to discriminate object shapes. Since…

Computer Vision and Pattern Recognition · Computer Science 2023-03-14 Sepehr Sameni , Simon Jenni , Paolo Favaro