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We present a fast and accurate analytical method for fluorescence lifetime imaging microscopy (FLIM) using the extreme learning machine (ELM). We used extensive metrics to evaluate ELM and existing algorithms. First, we compared these…

Biological Physics · Physics 2022-03-28 Zhenya Zang , Dong Xiao , Quan Wang , Zinuo Li , Wujun Xie , Yu Chen , David Day Uei Li

Fluorescence microscopy allows for a detailed inspection of cells, cellular networks, and anatomical landmarks by staining with a variety of carefully-selected markers visualized as color channels. Quantitative characterization of…

Computer Vision and Pattern Recognition · Computer Science 2021-08-26 Alvaro Gomariz , Tiziano Portenier , Patrick M. Helbling , Stephan Isringhausen , Ute Suessbier , César Nombela-Arrieta , Orcun Goksel

Human expertise in chemistry and biomedicine relies on contextual molecular understanding, a capability that large language models (LLMs) can extend through fine-grained alignment between molecular structures and text. Recent multimodal…

Computation and Language · Computer Science 2025-03-10 Sumin Ha , Jun Hyeong Kim , Yinhua Piao , Sun Kim

Multimodal and multi-information microscopy techniques such as Fluorescence Lifetime Imaging Microscopy (FLIM) extend the informational channels beyond intensity-based fluorescence microscopy but suffer from reduced image quality due to…

Image and Video Processing · Electrical Eng. & Systems 2025-04-15 Hao Chen , Julian Najera , Dagmawit Geresu , Meenal Datta , Cody Smith , Scott Howard

We propose a deep network that can be trained to tackle image reconstruction and classification problems that involve detection of multiple object instances, without any supervision regarding their whereabouts. The network learns to extract…

Computer Vision and Pattern Recognition · Computer Science 2020-12-08 Baptiste Angles , Yuhe Jin , Simon Kornblith , Andrea Tagliasacchi , Kwang Moo Yi

Lensless imaging stands out as a promising alternative to conventional lens-based systems, particularly in scenarios demanding ultracompact form factors and cost-effective architectures. However, such systems are fundamentally governed by…

Image and Video Processing · Electrical Eng. & Systems 2025-05-06 Jiesong Bai , Yuhao Yin , Yihang Dong , Xiaofeng Zhang , Chi-Man Pun , Xuhang Chen

Single-beam scanning electron microscopes (SEM) are widely used to acquire massive data sets for biomedical study, material analysis, and fabrication inspection. Datasets are typically acquired with uniform acquisition: applying the…

Image and Video Processing · Electrical Eng. & Systems 2021-01-11 Lu Mi , Hao Wang , Yaron Meirovitch , Richard Schalek , Srinivas C. Turaga , Jeff W. Lichtman , Aravinthan D. T. Samuel , Nir Shavit

Pretrained vision-language models (VLMs), such as CLIP, have shown remarkable potential in few-shot image classification and led to numerous effective transfer learning strategies. These methods leverage the pretrained knowledge of VLMs to…

Computer Vision and Pattern Recognition · Computer Science 2025-08-19 Dexia Chen , Qianjie Zhu , Weibing Li , Yue Yu , Tong Zhang , Ruixuan Wang

Ultrasound localization microscopy (ULM) refers to a promising medical imaging modality that systematically leverages the advantages of contrast-enhanced ultrasound (CEUS) to surpass the diffraction barrier and delineate the microvascular…

Image and Video Processing · Electrical Eng. & Systems 2022-09-22 Md Ashikuzzaman , Brandon Helfield , Hassan Rivaz

We study inference in stochastic block models (SBMs) through the lens of optimal transport (OT). We first establish that maximum likelihood variational inference (MLVI) can be interpreted as a semi-relaxed Gromov-Wasserstein (srGW)…

Machine Learning · Statistics 2026-05-29 Simon Queric , Cédric Vincent-Cuaz , Charles Bouveyron , Marco Corneli

When using supervised fine-tuning (SFT) to adapt large language models (LLMs) to specific domains, a significant challenge arises: should we use the entire SFT dataset for fine-tuning? Common practice often involves fine-tuning directly on…

Computation and Language · Computer Science 2025-05-26 Xiang Liu , Zhaoxiang Liu , Peng Wang , Kohou Wang , Huan Hu , Kai Wang , Shiguo Lian

Single-cell RNA sequencing (scRNA-seq) allows transcriptional profiling, and cell-type annotation of individual cells. However, sample preparation in typical scRNA-seq experiments often homogenizes the samples, thus spatial locations of…

Applications · Statistics 2024-08-28 Junhao Zhu , Kevin Zhang , Dehan Kong , Zhaolei Zhang

An efficient machine-learning-based method combined with a conventional local optimization technique has been proposed for exploring local energy minima of interstitial species in a crystal. In the proposed method, an effective initial…

Computational Physics · Physics 2020-11-18 Kazuaki Toyoura , Kansei Kanayama

Multimodal Large Language Models (MLLMs) encounter significant computational and memory bottlenecks from the massive number of visual tokens generated by high-resolution images or multi-image inputs. Previous token compression techniques…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Jiaying Zhu , Yurui Zhu , Xin Lu , Wenrui Yan , Dong Li , Kunlin Liu , Xueyang Fu , Zheng-Jun Zha

A lensfree spectral light-field fusion microscopy (LSLFM) system is presented for enabling contrast- and resolution-enhanced imaging of biological specimens. LSLFM consists of a pulsed multispectral lensfree microscope for capturing…

Low-light image enhancement (LLIE) aims to improve the illuminance of images due to insufficient light exposure. Recently, various lightweight learning-based LLIE methods have been proposed to handle the challenges of unfavorable prevailing…

Computer Vision and Pattern Recognition · Computer Science 2023-05-24 Yuantong Zhang , Baoxin Teng , Daiqin Yang , Zhenzhong Chen , Haichuan Ma , Gang Li , Wenpeng Ding

Structured illumination microscopy (SIM) uses a set of images captured with different illumination patterns to computationally reconstruct resolution beyond the diffraction limit. Here, we propose an alternative approach using a single…

Optics · Physics 2025-06-17 Ruiming Cao , Guanghan Meng , Laura Waller

In this paper, we address the problem of Multiple Transmitter Localization (MTL). MTL is to determine the locations of potential multiple transmitters in a field, based on readings from a distributed set of sensors. In contrast to the…

Networking and Internet Architecture · Computer Science 2022-03-23 Caitao Zhan , Mohammad Ghaderibaneh , Pranjal Sahu , Himanshu Gupta

This work presents a new deep learning approach for keystroke biometrics based on a novel Distance Metric Learning method (DML). DML maps input data into a learned representation space that reveals a "semantic" structure based on distances.…

Computer Vision and Pattern Recognition · Computer Science 2021-09-03 Aythami Morales , Julian Fierrez , Alejandro Acien , Ruben Tolosana , Ignacio Serna

Existing deep learning methods in multimode fiber (MMF) imaging often focus on simpler datasets, limiting their applicability to complex, real-world imaging tasks. These models are typically data-intensive, a challenge that becomes more…

Computer Vision and Pattern Recognition · Computer Science 2025-11-26 Jawaria Maqbool , M. Imran Cheema
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