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A neuron is a basic physiological and computational unit of the brain. While much is known about the physiological properties of a neuron, its computational role is poorly understood. Here we propose to view a neuron as a signal processing…

Neurons and Cognition · Quantitative Biology 2014-05-14 Tao Hu , Zaid J. Towfic , Cengiz Pehlevan , Alex Genkin , Dmitri B. Chklovskii

Drawing inspiration from our human brain that designs different neurons for different tasks, recent advances in deep learning have explored modifying a network's neurons to develop so-called task-driven neurons. Prototyping task-driven…

Machine Learning · Computer Science 2026-02-17 Hanyu Pei , Jing-Xiao Liao , Qibin Zhao , Ting Gao , Shijun Zhang , Xiaoge Zhang , Feng-Lei Fan

We present a novel methodology to enable control of a neuromorphic circuit in close analogy with the physiological neuromodulation of a single neuron. The methodology is general in that it only relies on a parallel interconnection of…

Neurons and Cognition · Quantitative Biology 2020-11-19 Luka Ribar , Rodolphe Sepulchre

Recent theoretical and experimental work in neuroscience has focused on the representational and dynamical character of neural manifolds --subspaces in neural activity space wherein many neurons coactivate. Importantly, neural populations…

Neurons and Cognition · Quantitative Biology 2024-10-21 Jacob Tanner , Sina Mansour L. , Ludovico Coletta , Alessandro Gozzi , Richard F. Betzel

Decoded Neurofeedback (DecNef) is a flourishing non-invasive approach to brain modulation with wide-ranging applications in neuromedicine and cognitive neuroscience. However, progress in DecNef research remains constrained by…

Neurons and Cognition · Quantitative Biology 2026-03-05 Alexander Olza , Roberto Santana , David Soto

This paper considers neural representation through the lens of active inference, a normative framework for understanding brain function. It delves into how living organisms employ generative models to minimize the discrepancy between…

Neurons and Cognition · Quantitative Biology 2023-10-24 Giovanni Pezzulo , Leo D'Amato , Francesco Mannella , Matteo Priorelli , Toon Van de Maele , Ivilin Peev Stoianov , Karl Friston

In complex systems, we often observe complex global behavior emerge from a collection of agents interacting with each other in their environment, with each individual agent acting only on locally available information, without knowing the…

Neural and Evolutionary Computing · Computer Science 2021-09-30 Yujin Tang , David Ha

Biological nervous systems consist of networks of diverse, sophisticated information processors in the form of neurons of different classes. In most artificial neural networks (ANNs), neural computation is abstracted to an activation…

Neural and Evolutionary Computing · Computer Science 2023-06-12 Joachim Winther Pedersen , Sebastian Risi

Neurons in real brains are enormously complex computational units. Among other things, they're responsible for transforming inbound electro-chemical vectors into outbound action potentials, updating the strengths of intermediate synapses,…

Artificial Intelligence · Computer Science 2020-11-16 Blake Camp , Jaya Krishna Mandivarapu , Rolando Estrada

Precise control of neural activity -- modulating target neurons deep in the brain while leaving nearby neurons unaffected -- is an outstanding challenge in neuroscience, generally approached using invasive techniques. This study…

Neurons and Cognition · Quantitative Biology 2025-06-17 Guy Gaziv , Sarah Goulding , Ani Ayvazian-Hancock , Yoon Bai , James J. DiCarlo

A main concern in cognitive neuroscience is to decode the overt neural spike train observations and infer latent representations under neural circuits. However, traditional methods entail strong prior on network structure and hardly meet…

Neurons and Cognition · Quantitative Biology 2019-11-22 Zhijie Chen , Junchi Yan , Longyuan Li , Xiaokang Yang

Feed-forward neural networks consist of a sequence of layers, in which each layer performs some processing on the information from the previous layer. A downside to this approach is that each layer (or module, as multiple modules can…

Machine Learning · Computer Science 2020-10-19 Alex Lamb , Anirudh Goyal , Agnieszka Słowik , Michael Mozer , Philippe Beaudoin , Yoshua Bengio

Although Deep Neural Networks have seen great success in recent years through various changes in overall architectures and optimization strategies, their fundamental underlying design remains largely unchanged. Computational neuroscience on…

Machine Learning · Computer Science 2019-12-17 Paul Bertens , Seong-Whan Lee

We propose a neural network model of multi-neuron interacting system that simulates neurons to interact each other through the surroundings of neuronal cell bodies. We physically model the neuronal cell surroundings, include the dendrites,…

Neurons and Cognition · Quantitative Biology 2021-07-05 Yu-Juan Sun , Wei-Min Zhang

Spontaneously evolving living systems can be modelled as continuous-time dynamical systems (DSs), whose evolution rules are determined by their velocity vector fields. We point out that because of their architectural plasticity, biological…

Adaptation and Self-Organizing Systems · Physics 2016-02-09 Natalia B. Janson , Christopher J. Marsden

Capsule networks are biologically inspired neural networks that group neurons into vectors called capsules, each explicitly representing an object or one of its parts. The routing mechanism connects capsules in consecutive layers, forming a…

Computer Vision and Pattern Recognition · Computer Science 2025-07-15 Riccardo Renzulli , Enzo Tartaglione , Marco Grangetto

Network science can offer fundamental insights into the structural and functional properties of complex systems. For example, it is widely known that neuronal circuits tend to organize into basic functional topological modules, called…

Adaptation and Self-Organizing Systems · Physics 2022-08-03 Matteo Zambra , Alberto Testolin , Amos Maritan

Foundation models have shown remarkable success in fitting biological visual systems; however, their black-box nature inherently limits their utility for understanding brain function. Here, we peek inside a SOTA foundation model of neural…

Neurons and Cognition · Quantitative Biology 2026-01-30 Johannes Bertram , Luciano Dyballa , Anderson Keller , Savik Kinger , Steven W. Zucker

Mounting evidence in neuroscience suggests the possibility of neuronal representations that individual neurons serve as the substrates of different mental representations in a point-to-point way. Combined with associationism, it can…

Neurons and Cognition · Quantitative Biology 2021-09-06 Chiyin Zheng

Systems neuroscience relies on two complementary views of neural data, characterized by single neuron tuning curves and analysis of population activity. These two perspectives combine elegantly in neural latent variable models that…