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The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing…

Quantitative Methods · Quantitative Biology 2024-09-10 Yizhen Zheng , Huan Yee Koh , Maddie Yang , Li Li , Lauren T. May , Geoffrey I. Webb , Shirui Pan , George Church

Recent advancements in artificial intelligence (AI), especially large language models (LLMs), have significantly advanced healthcare applications and demonstrated potentials in intelligent medical treatment. However, there are conspicuous…

Computation and Language · Computer Science 2025-05-26 Qinkai Yu , Mingyu Jin , Dong Shu , Chong Zhang , Lizhou Fan , Wenyue Hua , Suiyuan Zhu , Yanda Meng , Zhenting Wang , Mengnan Du , Yongfeng Zhang

Mental health is a growing global concern, prompting interest in AI-driven solutions to expand access to psychosocial support. \emph{Peer support}, grounded in lived experience, offers a valuable complement to professional care. However,…

Human-Computer Interaction · Computer Science 2026-04-10 Kellie Yu Hui Sim , Roy Ka-Wei Lee , Kenny Tsu Wei Choo

Large language models (LLMs) could be valuable personal AI agents across various domains, provided they can precisely follow user instructions. However, recent studies have shown significant limitations in LLMs' instruction-following…

Artificial Intelligence · Computer Science 2025-03-31 Juyeon Heo , Miao Xiong , Christina Heinze-Deml , Jaya Narain

This work presents an analytical framework for the design and analysis of LLM-based algorithms, i.e., algorithms that contain one or multiple calls of large language models (LLMs) as sub-routines and critically rely on the capabilities of…

Machine Learning · Computer Science 2025-10-14 Yanxi Chen , Yaliang Li , Bolin Ding , Jingren Zhou

In recent years, Large Language Models (LLMs) have achieved significant success in natural language processing (NLP) and various interdisciplinary areas. However, applying LLMs to chemistry is a complex task that requires specialized domain…

Machine Learning · Computer Science 2024-02-05 Chang Liao , Yemin Yu , Yu Mei , Ying Wei

Large Language Models (LLMs) have demonstrated their transformative potential across numerous disciplinary studies, reshaping the existing research methodologies and fostering interdisciplinary collaboration. However, a systematic…

Computation and Language · Computer Science 2025-07-14 Lu Xiang , Yang Zhao , Yaping Zhang , Chengqing Zong

Large language models (LLMs) can support democratic deliberation at scales previously constrained by turn-taking and facilitation bandwidth. Recent work shows that LLM-generated group statements are often preferred over human-mediated…

Computation and Language · Computer Science 2026-05-27 Wajdi Zaghouani

Autonomous agents utilizing Large Language Models (LLMs) have demonstrated remarkable capabilities in isolated medical tasks like diagnosis and image analysis, but struggle with integrated clinical workflows that connect diagnostic…

Artificial Intelligence · Computer Science 2025-10-14 Hongjie Zheng , Zesheng Shi , Ping Yi

Large language models (LLMs) frequently generate confident yet inaccurate responses, introducing significant risks for deployment in safety-critical domains. We present a novel, test-time approach to detecting model hallucination through…

Machine Learning · Computer Science 2025-10-07 Hazel Kim , Tom A. Lamb , Adel Bibi , Philip Torr , Yarin Gal

Global healthcare providers are exploring use of large language models (LLMs) to provide medical advice to the public. LLMs now achieve nearly perfect scores on medical licensing exams, but this does not necessarily translate to accurate…

Explainable recommendations help improve the transparency and credibility of recommendation systems, and play an important role in personalized recommendation scenarios. At present, methods for explainable recommendation based on large…

Information Retrieval · Computer Science 2026-04-07 Xiangchen Pan , Wei Wei

The use of large language models (LLMs) in qualitative analysis offers enhanced efficiency but raises questions about their alignment with the contextual nature of research for design (RfD). This research examines the trustworthiness of…

Human-Computer Interaction · Computer Science 2025-04-24 Joel Oksanen , Andrés Lucero , Perttu Hämäläinen

In this study, we propose a structured methodology that utilizes large language models (LLMs) in a cost-efficient and parsimonious manner, integrating the strengths of scholars and machines while offsetting their respective weaknesses. Our…

Computation and Language · Computer Science 2025-12-30 Navid Asgari , Benjamin M. Cole

Recent research has shown that hallucinations, omissions, and biases are prevalent in everyday use-cases of LLMs. However, chatbots used in medical contexts must provide consistent advice in situations where non-medical factors are…

Computation and Language · Computer Science 2025-11-05 Jonathan Liu , Haoling Qiu , Jonathan Lasko , Damianos Karakos , Mahsa Yarmohammadi , Mark Dredze

Therapy recommendation for chronic patients with multimorbidity is challenging due to risks of treatment conflicts. Existing decision support systems face scalability limitations. Inspired by the way in which general practitioners (GP)…

Artificial Intelligence · Computer Science 2025-07-16 Yicong Wu , Ting Chen , Irit Hochberg , Zhoujian Sun , Ruth Edry , Zhengxing Huang , Mor Peleg

This paper introduces a system that integrates large language models (LLMs) into the clinical trial retrieval process, enhancing the effectiveness of matching patients with eligible trials while maintaining information privacy and allowing…

Information Retrieval · Computer Science 2024-11-01 Georgios Peikos , Pranav Kasela , Gabriella Pasi

The medical ecosystem consists of the training of new clinicians and researchers, the practice of clinical medicine, and areas of adjacent research. There are many aspects of these domains that could benefit from the application of task…

Computers and Society · Computer Science 2025-07-29 Elisha D. O. Roberson

Large language models (LLMs) are transforming society, powering applications from smartphone assistants to autonomous driving. Yet cloud-based LLM services alone cannot serve a growing class of applications, including those operating under…

Signal Processing · Electrical Eng. & Systems 2026-05-12 Liangqi Yuan , Wenzhi Fang , Shiqiang Wang , H. Vincent Poor , Christopher G. Brinton

The field of chemistry and Artificial Intelligence (AI) intersection is an area of active research that aims to accelerate scientific discovery. The integration of large language models (LLMs) with scientific modalities has shown…

Computation and Language · Computer Science 2024-07-16 Dimitris Gkoumas