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Accurate and verifiable large language model (LLM) simulations of human research subjects promise an accessible data source for understanding human behavior and training new AI systems. However, results to date have been limited, and few…

Human-Computer Interaction · Computer Science 2025-06-06 Jacy Reese Anthis , Ryan Liu , Sean M. Richardson , Austin C. Kozlowski , Bernard Koch , James Evans , Erik Brynjolfsson , Michael Bernstein

Large Language Models (LLMs) have emerged as powerful candidates to inform clinical decision-making processes. While these models play an increasingly prominent role in shaping the digital landscape, two growing concerns emerge in…

Computation and Language · Computer Science 2024-04-24 Raphael Poulain , Hamed Fayyaz , Rahmatollah Beheshti

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

Large Language Models (LLMs) are increasingly employed for simulating human behaviors across diverse domains. However, our position is that current LLM-based human simulations remain insufficiently reliable, as evidenced by significant…

Computation and Language · Computer Science 2025-12-02 Qian Wang , Jiaying Wu , Zichen Jiang , Zhenheng Tang , Bingqiao Luo , Nuo Chen , Wei Chen , Bingsheng He

Large Language Models (LLMs) have shown remarkable capabilities in general natural language processing tasks but often fall short in complex reasoning tasks. Recent studies have explored human-like problem-solving strategies, such as…

Computation and Language · Computer Science 2023-12-19 Zhenran Xu , Senbao Shi , Baotian Hu , Jindi Yu , Dongfang Li , Min Zhang , Yuxiang Wu

Large language models (LLMs) are emerging as promising tools for mental health care, offering scalable support through their ability to generate human-like responses. However, the effectiveness of these models in clinical settings remains…

Artificial Intelligence · Computer Science 2024-08-22 Yining Hua , Hongbin Na , Zehan Li , Fenglin Liu , Xiao Fang , David Clifton , John Torous

Large Language Models (LLMs) and Large Reasoning Models (LRMs) offer transformative potential for high-stakes domains like finance and law, but their tendency to hallucinate, generating factually incorrect or unsupported content, poses a…

Artificial Intelligence · Computer Science 2026-01-16 Ahmad Pesaranghader , Erin Li

Large language models (LLMs) are beginning to reshape how chemists plan and run reactions in organic synthesis. Trained on millions of reported transformations, these text-based models can propose synthetic routes, forecast reaction…

Artificial Intelligence · Computer Science 2025-08-08 Kartar Kumar Lohana Tharwani , Rajesh Kumar , Sumita , Numan Ahmed , Yong Tang

Clinical trial matching is a key process in health delivery and discovery. In practice, it is plagued by overwhelming unstructured data and unscalable manual processing. In this paper, we conduct a systematic study on scaling clinical trial…

As AI becomes fundamental in sectors like healthcare, explainable AI (XAI) tools are essential for trust and transparency. However, traditional user studies used to evaluate these tools are often costly, time consuming, and difficult to…

Artificial Intelligence · Computer Science 2024-10-24 Francesco Bombassei De Bona , Gabriele Dominici , Tim Miller , Marc Langheinrich , Martin Gjoreski

Multi-AI collaboration, such as ensembling or debating large language models (LLMs), is a promising paradigm for aggregating information and boosting performance. A foundational step in these pipelines is to feed the responses of several…

Machine Learning · Computer Science 2026-05-26 Yichi Zhang , Kevin Lu , Yuang Zhang , Jie Gao , Lirong Xia , Fang-Yi Yu

Large language models (LLMs) are highly capable but face latency challenges in real-time applications, such as conducting online hallucination detection. To overcome this issue, we propose a novel framework that leverages a small language…

Computation and Language · Computer Science 2024-08-26 Mengya Hu , Rui Xu , Deren Lei , Yaxi Li , Mingyu Wang , Emily Ching , Eslam Kamal , Alex Deng

Conversational agents are increasingly used in healthcare, and the integration of Large Language Models (LLMs) has significantly enhanced their capabilities. When integrated into social robots, LLMs offer the potential for more natural…

Computers and Society · Computer Science 2024-11-25 Robert Ranisch , Joschka Haltaufderheide

As AI agents built on large language models (LLMs) become increasingly embedded in society, issues of coordination, control, delegation, and accountability are entangled with concerns over their reliability. To design and implement LLM…

Computers and Society · Computer Science 2025-12-09 R. Patrick Xian , Garry A. Gabison , Ahmed Alaa , Christoph Riedl , Grigorios G. Chrysos

Multimodal Large Language Models (MLLMs) have tremendous potential to improve the accuracy, availability, and cost-effectiveness of healthcare by providing automated solutions or serving as aids to medical professionals. Despite promising…

Computer Vision and Pattern Recognition · Computer Science 2025-05-22 Mohammad Shahab Sepehri , Zalan Fabian , Maryam Soltanolkotabi , Mahdi Soltanolkotabi

Large Language Models (LLMs) offer a promising approach to enhancing Explainable AI (XAI) by transforming complex machine learning outputs into easy-to-understand narratives, making model predictions more accessible to users, and helping…

Artificial Intelligence · Computer Science 2025-04-02 Ahsan Bilal , David Ebert , Beiyu Lin

Large language models (LLMs) are rapidly transforming materials science. This review examines recent LLM applications across the materials discovery pipeline, focusing on three key areas: mining scientific literature , predictive modelling,…

Computation and Language · Computer Science 2025-11-17 Fengxu Yang , Weitong Chen , Jack D. Evans

Robust therapeutic relationships between counselors and clients are fundamental to counseling effectiveness. The assessment of therapeutic alliance is well-established in traditional face-to-face therapy but may not directly translate to…

Computation and Language · Computer Science 2024-10-10 Anqi Li , Yu Lu , Nirui Song , Shuai Zhang , Lizhi Ma , Zhenzhong Lan

Artificial General Intelligence falls short when communicating role specific nuances to other systems. This is more pronounced when building autonomous LLM agents capable and designed to communicate with each other for real world problem…

Machine Learning · Computer Science 2024-03-19 Rabimba Karanjai , Weidong Shi

Uncertainty estimation is a necessary component when implementing AI in high-risk settings, such as autonomous cars, medicine, or insurances. Large Language Models (LLMs) have seen a surge in popularity in recent years, but they are subject…

Machine Learning · Computer Science 2024-12-09 Gabriel Y. Arteaga , Thomas B. Schön , Nicolas Pielawski
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