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Clinical predictive models often rely on patients' electronic health records (EHR), but integrating medical knowledge to enhance predictions and decision-making is challenging. This is because personalized predictions require personalized…

Artificial Intelligence · Computer Science 2024-01-19 Pengcheng Jiang , Cao Xiao , Adam Cross , Jimeng Sun

Electronic Health Records (EHRs) and routine documentation practices play a vital role in patients' daily care, providing a holistic record of health, diagnoses, and treatment. However, complex and verbose EHR narratives overload healthcare…

Computation and Language · Computer Science 2025-02-26 Yanjun Gao , Ruizhe Li , Emma Croxford , John Caskey , Brian W Patterson , Matthew Churpek , Timothy Miller , Dmitriy Dligach , Majid Afshar

Clinical risk prediction using electronic health records (EHRs) is vital to facilitate timely interventions and clinical decision support. However, modeling heterogeneous and irregular temporal EHR data presents significant challenges. We…

Machine Learning · Computer Science 2025-11-04 Kun-Wei Lin , Yu-Chen Kuo , Hsin-Yao Wang , Yi-Ju Tseng

Accurate interpretation of pediatric dental clinical records and safe antibiotic prescribing remain persistent challenges in dental informatics. Traditional rule-based clinical decision support systems struggle with unstructured dental…

Computation and Language · Computer Science 2025-12-11 Zihan Han , Junyan Ge , Caifeng Li

Large language models (LLMs) have demonstrated significant potential in clinical decision support. Yet LLMs still suffer from hallucinations and lack fine-grained contextual medical knowledge, limiting their high-stake healthcare…

Computation and Language · Computer Science 2025-04-22 Pengcheng Jiang , Cao Xiao , Minhao Jiang , Parminder Bhatia , Taha Kass-Hout , Jimeng Sun , Jiawei Han

Large Language Models (LLMs) are being adopted at an unprecedented rate, yet still face challenges in knowledge-intensive domains like biomedicine. Solutions such as pre-training and domain-specific fine-tuning add substantial computational…

Large language models (LLMs) have recently emerged as powerful tools, finding many medical applications. LLMs' ability to coalesce vast amounts of information from many sources to generate a response-a process similar to that of a human…

Large Language Models (LLMs) generate fluent answers but can struggle with trustworthy, domain-specific reasoning. We evaluate whether domain knowledge graphs (KGs) improve Retrieval-Augmented Generation (RAG) for healthcare by constructing…

Computation and Language · Computer Science 2026-01-23 Sydney Anuyah , Mehedi Mahmud Kaushik , Hao Dai , Rakesh Shiradkar , Arjan Durresi , Sunandan Chakraborty

The increasing reliance on Large Language Models (LLMs) for health information seeking can pose severe risks due to the potential for misinformation and the complexity of these topics. This paper introduces KNOWNET a visualization system…

Human-Computer Interaction · Computer Science 2024-09-27 Youfu Yan , Yu Hou , Yongkang Xiao , Rui Zhang , Qianwen Wang

Clinical diagnosis is time-consuming, requiring intensive interactions between patients and medical professionals. While large language models (LLMs) could ease the pre-diagnostic workload, their limited domain knowledge hinders effective…

Computation and Language · Computer Science 2026-03-03 Liwen Sun , Xiang Yu , Ming Tan , Zhuohao Chen , Anqi Cheng , Ashutosh Joshi , Chenyan Xiong

In electronic health record (EHR) mining, learning high-quality representations of medical concepts (e.g., standardized diagnosis, medication, and procedure codes) is fundamental for downstream clinical prediction. However, ro bust concept…

Machine Learning · Computer Science 2026-05-05 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Chen Chen , Dongjie Wang , Zijun Yao

Large language models (LLMs) offer new opportunities for constructing knowledge graphs (KGs) from unstructured clinical narratives. However, existing approaches often rely on structured inputs and lack robust validation of factual accuracy…

Artificial Intelligence · Computer Science 2026-01-06 Udiptaman Das , Krishnasai B. Atmakuri , Duy Ho , Chi Lee , Yugyung Lee

Large language models (LLMs) are increasingly used in the mental health domain, yet it remains unclear how well they capture related biomedical knowledge and how reliably they apply it to clinically salient structured judgments. Here, we…

Computation and Language · Computer Science 2026-05-18 Weixin Liu , Congning Ni , Shelagh A. Mulvaney , Susannah L. Rose , Murat Kantarcioglu , Bradley A. Malin , Zhijun Yin

Knowledge Graphs (KGs) represent relationships between entities in a graph structure and have been widely studied as promising tools for realizing recommendations that consider the accurate content information of items. However, traditional…

Information Retrieval · Computer Science 2024-12-18 Keigo Sakurai , Ren Togo , Takahiro Ogawa , Miki Haseyama

Knowledge graph (KG) embedding has been used to benefit the diagnosis of animal diseases by analyzing electronic medical records (EMRs), such as notes and veterinary records. However, learning representations to capture entities and…

Artificial Intelligence · Computer Science 2023-09-08 Van Thuy Hoang , Sang Thanh Nguyen , Sangmyeong Lee , Jooho Lee , Luong Vuong Nguyen , O-Joun Lee

Knowledge graph (KG) is an abstraction that can be extracted from text corpora and used for in-depth reasoning. Prior work has leveraged KGs to fine-tune language models (LMs), enabling domain-specific superintelligence. In this work, we…

Computation and Language · Computer Science 2026-05-28 Jake Stephen , Niraj K. Jha

The task of multi-hop link prediction within knowledge graphs (KGs) stands as a challenge in the field of knowledge graph analysis, as it requires the model to reason through and understand all intermediate connections before making a…

Computation and Language · Computer Science 2025-06-17 Dong Shu , Tianle Chen , Mingyu Jin , Chong Zhang , Mengnan Du , Yongfeng Zhang

The automatic construction of knowledge graphs (KGs) is an important research area in medicine, with far-reaching applications spanning drug discovery and clinical trial design. These applications hinge on the accurate identification of…

Computation and Language · Computer Science 2025-01-30 Vahan Arsenyan , Spartak Bughdaryan , Fadi Shaya , Kent Small , Davit Shahnazaryan

Knowledge graph completion (KGC) is a widely used method to tackle incompleteness in knowledge graphs (KGs) by making predictions for missing links. Description-based KGC leverages pre-trained language models to learn entity and relation…

Computation and Language · Computer Science 2024-03-05 Derong Xu , Ziheng Zhang , Zhenxi Lin , Xian Wu , Zhihong Zhu , Tong Xu , Xiangyu Zhao , Yefeng Zheng , Enhong Chen

Biomedical knowledge graphs (KGs) hold rich information on entities such as diseases, drugs, and genes. Predicting missing links in these graphs can boost many important applications, such as drug design and repurposing. Recent work has…

Computation and Language · Computer Science 2021-09-22 Rahul Nadkarni , David Wadden , Iz Beltagy , Noah A. Smith , Hannaneh Hajishirzi , Tom Hope
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