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Extensive adoption of electronic health records (EHRs) offers opportunities for their use in various downstream clinical analyses. To accomplish this purpose, enriching an EHR cohort with external knowledge (e.g., standardized medical…

Machine Learning · Computer Science 2024-06-13 Ahmad Wisnu Mulyadi , Heung-Il Suk

In recent years, the introduction of knowledge graphs (KGs) has significantly advanced recommender systems by facilitating the discovery of potential associations between items. However, existing methods still face several limitations.…

Information Retrieval · Computer Science 2025-04-18 Ziqiang Cui , Yunpeng Weng , Xing Tang , Fuyuan Lyu , Dugang Liu , Xiuqiang He , Chen Ma

Knowledge Graphs (KGs) are foundational to applications such as search, question answering, and recommendation. Conventional knowledge graph construction methods are predominantly static, rely ing on a single-step construction from a fixed…

Artificial Intelligence · Computer Science 2026-03-23 Weidong Bao , Yilin Wang , Ruyu Gao , Fangling Leng , Yubin Bao , Ge Yu

The recent proliferation of large language models (LLMs) holds the potential to revolutionize healthcare, with strong capabilities in diverse medical tasks. Yet, deploying LLMs in high-stakes healthcare settings requires rigorous…

Machine Learning · Computer Science 2025-12-22 Shasha Zhou , Mingyu Huang , Jack Cole , Charles Britton , Ming Yin , Jan Wolber , Ke Li

Large Language Models (LLMs) and Knowledge Graphs (KGs) offer a promising approach to robust and explainable Question Answering (QA). While LLMs excel at natural language understanding, they suffer from knowledge gaps and hallucinations.…

Machine Learning · Computer Science 2025-04-15 Jasper Linders , Jakub M. Tomczak

This paper presents an exhaustive quantitative and qualitative evaluation of Large Language Models (LLMs) for Knowledge Graph (KG) construction and reasoning. We engage in experiments across eight diverse datasets, focusing on four…

Computation and Language · Computer Science 2024-12-30 Yuqi Zhu , Xiaohan Wang , Jing Chen , Shuofei Qiao , Yixin Ou , Yunzhi Yao , Shumin Deng , Huajun Chen , Ningyu Zhang

Understanding complex biomolecular mechanisms requires multi-step reasoning across molecular interactions, signaling cascades, and metabolic pathways. While large language models(LLMs) show promise in such tasks, their application to…

Artificial Intelligence · Computer Science 2025-11-12 Tianwen Lyu , Xiang Zhuang , Keyan Ding , Xinzhe Cao , Lei Liang , Wei Zhao , Qiang Zhang , Huajun Chen

Knowledge graphs and structural causal models have each proven valuable for organizing biomedical knowledge and estimating causal effects, but remain largely disconnected: knowledge graphs encode qualitative relationships focusing on facts…

Artificial Intelligence · Computer Science 2025-05-13 Sumyyah Toonsi , Paul Schofield , Robert Hoehndorf

Knowledge Graph Embedding (KGE) techniques are crucial in learning compact representations of entities and relations within a knowledge graph, facilitating efficient reasoning and knowledge discovery. While existing methods typically focus…

Computation and Language · Computer Science 2024-10-29 Pengcheng Jiang , Lang Cao , Cao Xiao , Parminder Bhatia , Jimeng Sun , Jiawei Han

Chain-of-thought (CoT) reasoning boosts large language models' (LLMs) performance on complex tasks but faces two key limitations: a lack of reliability when solely relying on LLM-generated reasoning chains and lower reasoning performance…

Computation and Language · Computer Science 2025-09-11 Feiyang Li , Peng Fang , Zhan Shi , Arijit Khan , Fang Wang , Weihao Wang , Xin Zhang , Yongjian Cui

Knowledge graphs (KGs) are increasingly used to support large lan guage model (LLM) reasoning, but standard triplet-based KGs treat each relation as globally valid. In many settings, whether a relation should count as evidence depends on…

Computation and Language · Computer Science 2026-04-28 Yao Wang , Zixu Geng , Jun Yan

The rapid expansion of publicly-available medical data presents a challenge for clinicians and researchers alike, increasing the gap between the volume of scientific literature and its applications. The steady growth of studies and findings…

Artificial Intelligence · Computer Science 2025-08-06 Taine J. Elliott , Stephen P. Levitt , Ken Nixon , Martin Bekker

Objective: To combine medical knowledge and medical data to interpretably predict the risk of disease. Methods: We formulated the disease prediction task as a random walk along a knowledge graph (KG). Specifically, we build a KG to record…

Machine Learning · Computer Science 2023-01-09 Zhoujian Sun , Wei Dong , Jinlong Shi , Zhengxing Huang

Knowledge Graph Retrieval-Augmented Generation (KG-RAG) extends the RAG paradigm by incorporating structured knowledge from knowledge graphs, enabling Large Language Models (LLMs) to perform more precise and explainable reasoning. While…

Computation and Language · Computer Science 2026-02-04 Jing Ren , Bowen Li , Ziqi Xu , Xikun Zhang , Haytham Fayek , Xiaodong Li

Schema matching is a critical task in data integration, particularly in the medical domain where disparate Electronic Health Record (EHR) systems must be aligned to standard models like OMOP CDM. While Large Language Models (LLMs) have…

Artificial Intelligence · Computer Science 2025-12-02 Mingyu Jeon , Jaeyoung Suh , Suwan Cho

The advent of large language models (LLMs) has revolutionized the integration of knowledge graphs (KGs) in biomedical and cognitive sciences, overcoming limitations in traditional machine learning methods for capturing intricate semantic…

Artificial Intelligence · Computer Science 2025-10-09 Ali Sarabadani , Kheirolah Rahsepar Fard

Knowledge graphs (KGs) are valuable for representing structured, interconnected information across domains, enabling tasks like semantic search, recommendation systems and inference. A pertinent challenge with KGs, however, is that many…

Computation and Language · Computer Science 2024-12-17 Haji Gul , Abdul Ghani Naim , Ajaz A. Bhat

Knowledge Graphs (KG) provide us with a structured, flexible, transparent, cross-system, and collaborative way of organizing our knowledge and data across various domains in society and industrial as well as scientific disciplines. KGs…

Chain-of-Thought (CoT) prompting along with sub-question generation and answering has enhanced multi-step reasoning capabilities of Large Language Models (LLMs). However, prompting the LLMs to directly generate sub-questions is suboptimal…

Computation and Language · Computer Science 2024-06-25 Jinyoung Park , Ameen Patel , Omar Zia Khan , Hyunwoo J. Kim , Joo-Kyung Kim

Artificial intelligence (AI) is reshaping modern healthcare by advancing disease diagnosis, treatment decision-making, and biomedical research. Among AI technologies, large language models (LLMs) have become especially impactful, enabling…

Artificial Intelligence · Computer Science 2025-11-18 Zhengda Wang , Daqian Shi , Jingyi Zhao , Xiaolei Diao , Xiongfeng Tang , Yanguo Qin