English
Related papers

Related papers: Aligning LLMs with Biomedical Knowledge using Bala…

200 papers

Supervised fine-tuning (SFT) is a standard approach to adapting large language models (LLMs) to new domains. In this work, we improve the statistical efficiency of SFT by selecting an informative subset of training examples. Specifically,…

Machine Learning · Computer Science 2025-05-22 Rohan Deb , Kiran Thekumparampil , Kousha Kalantari , Gaurush Hiranandani , Shoham Sabach , Branislav Kveton

The alignment of large language models (LLMs) is crucial not only for unlocking their potential in specific tasks but also for ensuring that responses meet human expectations and adhere to safety and ethical principles. Current alignment…

Computation and Language · Computer Science 2024-06-18 Ruijun Chen , Jiehao Liang , Shiping Gao , Fanqi Wan , Xiaojun Quan

Large language models (LLMs) are deep learning algorithms being used to perform natural language processing tasks in various fields, from social sciences to finance and biomedical sciences. Developing and training a new LLM can be very…

General Finance · Quantitative Finance 2024-01-23 Valentina Aparicio , Daniel Gordon , Sebastian G. Huayamares , Yuhuai Luo

We explore efficient strategies to fine-tune decoder-only Large Language Models (LLMs) for downstream text classification under resource constraints. Two approaches are investigated: (1) attaching a classification head to a pretrained…

Computation and Language · Computer Science 2026-05-26 Amirhossein Yousefiramandi , Ciaran Cooney

Continual post-training (CPT) is a popular and effective technique for adapting foundation models like multimodal large language models to specific and ever-evolving downstream tasks. While existing research has primarily concentrated on…

Machine Learning · Computer Science 2026-01-22 Song Lai , Haohan Zhao , Rong Feng , Changyi Ma , Wenzhuo Liu , Hongbo Zhao , Xi Lin , Dong Yi , Qingfu Zhang , Hongbin Liu , Gaofeng Meng , Fei Zhu

Large language models (LLMs) have recently been adapted to tabular prediction by serializing structured features into natural language, but their performance in low-data regimes remains limited compared to gradient-boosted decision trees…

Machine Learning · Computer Science 2026-05-12 Yi-Siang Wang , Kuan-Yu Chen , Yu-Chen Den , Darby Tien-Hao Chang

Advancements in Large Language Models (LLMs) have significantly enhanced instruction-following capabilities. However, most Instruction Fine-Tuning (IFT) datasets are predominantly in English, limiting model performance in other languages.…

Computation and Language · Computer Science 2024-07-03 Sathish Reddy Indurthi , Wenxuan Zhou , Shamil Chollampatt , Ravi Agrawal , Kaiqiang Song , Lingxiao Zhao , Chenguang Zhu

Reasoning is a cognitive process of using evidence to reach a sound conclusion. The reasoning capability is essential for large language models (LLMs) to serve as the brain of the artificial general intelligence agent. Recent studies reveal…

Computation and Language · Computer Science 2023-09-06 Peiyi Wang , Lei Li , Liang Chen , Feifan Song , Binghuai Lin , Yunbo Cao , Tianyu Liu , Zhifang Sui

We present Branch-Train-Merge (BTM), a communication-efficient algorithm for embarrassingly parallel training of large language models (LLMs). We show it is possible to independently train subparts of a new class of LLMs on different…

Computation and Language · Computer Science 2022-08-08 Margaret Li , Suchin Gururangan , Tim Dettmers , Mike Lewis , Tim Althoff , Noah A. Smith , Luke Zettlemoyer

Supervised Fine-Tuning (SFT) of the language backbone plays a pivotal role in adapting Vision-Language Models (VLMs) to specialized domains such as medical reasoning. However, existing SFT practices often rely on unfiltered textual datasets…

Computation and Language · Computer Science 2026-03-17 Xinlin Zhuang , Feilong Tang , Haolin Yang , Xiwei Liu , Ming Hu , Huifa Li , Haochen Xue , Junjun He , Zongyuan Ge , Yichen Li , Ying Qian , Imran Razzak

To acquire instruction-following capabilities, large language models (LLMs) undergo instruction tuning, where they are trained on instruction-response pairs using next-token prediction (NTP). Efforts to improve instruction tuning often…

Computation and Language · Computer Science 2026-04-21 Yuxin Xiao , Shujian Zhang , Wenxuan Zhou , Marzyeh Ghassemi , Sanqiang Zhao

Parameter Efficient Finetuning (PEFT) has emerged as a viable solution for improving the performance of Large Language Models (LLMs) without requiring massive resources and compute. Prior work on multilingual evaluation has shown that there…

Computation and Language · Computer Science 2024-07-23 Divyanshu Aggarwal , Ashutosh Sathe , Ishaan Watts , Sunayana Sitaram

The rapid growth of biomedical literature poses challenges for manual knowledge curation and synthesis. Biomedical Natural Language Processing (BioNLP) automates the process. While Large Language Models (LLMs) have shown promise in general…

In recent years, there has been substantial progress in using pretrained Language Models (LMs) on a range of tasks aimed at improving the understanding of biomedical texts. Nonetheless, existing biomedical LLMs show limited comprehension of…

Computation and Language · Computer Science 2025-09-10 Andrey Sakhovskiy , Elena Tutubalina

Aligned Large Language Models (LLMs) showcase remarkable versatility, capable of handling diverse real-world tasks. Meanwhile, aligned LLMs are also expected to exhibit speciality, excelling in specific applications. However, fine-tuning…

Computation and Language · Computer Science 2025-02-25 Hengyuan Zhang , Yanru Wu , Dawei Li , Sak Yang , Rui Zhao , Yong Jiang , Fei Tan

Open-source, multilingual medical large language models (LLMs) have the potential to serve linguistically diverse populations across different regions. Adapting generic LLMs for healthcare often requires continual pretraining, but this…

Computation and Language · Computer Science 2024-09-10 Meng Zhou , Surajsinh Parmar , Anubhav Bhatti

While Supervised Fine-Tuning (SFT) and Rejection Sampling Fine-Tuning (RFT) are standard for LLM alignment, they either rely on costly expert data or discard valuable negative samples, leading to data inefficiency. To address this, we…

Machine Learning · Computer Science 2026-04-24 Zehua Liu , Shuqi Liu , Tao Zhong , Mingxuan Yuan

Scientific literature understanding is crucial for extracting targeted information and garnering insights, thereby significantly advancing scientific discovery. Despite the remarkable success of Large Language Models (LLMs), they face…

Machine Learning · Computer Science 2025-04-21 Sihang Li , Jin Huang , Jiaxi Zhuang , Yaorui Shi , Xiaochen Cai , Mingjun Xu , Xiang Wang , Linfeng Zhang , Guolin Ke , Hengxing Cai

Retrieval-augmented generation (RAG) enhances large language models (LLMs) by integrating external knowledge retrieved from a knowledge base. However, its effectiveness is fundamentally constrained by the reliability of both the retriever…

Computation and Language · Computer Science 2025-01-31 Yiteng Tu , Weihang Su , Yujia Zhou , Yiqun Liu , Qingyao Ai

Reinforcement Learning from Human Feedback (RLHF), using algorithms like Proximal Policy Optimization (PPO), aligns Large Language Models (LLMs) with human values but is costly and unstable. Alternatives have been proposed to replace PPO or…

Computation and Language · Computer Science 2026-04-03 Liang Zhu , Feiteng Fang , Yuelin Bai , Longze Chen , Zhexiang Zhang , Minghuan Tan , Min Yang