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Purpose Study on curcumin dissolved in natural deep eutectic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods The concentration of dissolved curcumin in NADES was measured. Simulated…
Neural inflammation immediately follows the onset of ischemic stroke. During this process, microglial cells can be activated into two different phenotypes: the M1 phenotype, which can worsen brain injury by producing pro-inflammatory…
Linear constrained optimization techniques have been applied to many real-world settings. In recent years, inferring the unknown parameters and functions inside an optimization model has also gained traction. This inference is often based…
Alzheimer disease (AD) is a neurodegenerative disease that lacks specific treatment options. Natural drugs have displayed neuroprotective effects; however, their high-throughput discovery is challenging because of the expense of…
This essay is presented with two principal objectives in mind: first, to document the prevalence of fractals at all levels of the nervous system, giving credence to the notion of their functional relevance; and second, to draw attention to…
Lead is a naturally-occurring element. It has been known to man for a long time, and it is one of the longest established poisons. The current consensus is that no level of lead exposure should be deemed "safe." New evidence regarding the…
Stroke is a major cause of death and disability worldwide. Accurate outcome and evolution prediction has the potential to revolutionize stroke care by individualizing clinical decision-making leading to better outcomes. However, despite a…
We investigate the evolution of tumor growth relying on a nonlinear model of partial differential equations which incorporates mechanical laws for tissue compression combined with rules for nutrients availability and drug application.…
Nanotechnology has been one of the fastest growing fields in the last three decades. Nanomaterials (sized 1-100 nm) has a wide spectrum of potential applications in many fields, applied as coating materials or in treatment and diagnosis.…
How do we know if a particular medical treatment actually works? Ideally one would consult all available evidence from relevant clinical trials. Unfortunately, such results are primarily disseminated in natural language scientific articles,…
I present a theory of schizophrenia (SZ) that mechanistically explains its etiology, symptoms, pathophysiology, and treatment. SZ involves the chronic release of membrane polyunsaturated fatty acids (PUFAs) and their utilization for the…
Accurate estimation of brain infarction (i.e., irreversibly damaged tissue) is critical for guiding treatment decisions in acute ischemic stroke. Reliable infarct prediction informs key clinical interventions, including the need for patient…
Stroke is a leading cause of long-term disability and the second most common cause of death worldwide. Although acute treatments have advanced, recovery remains challenging and limited. Brain-computer interfaces (BCIs) have emerged as a…
Background: Hemiparesis after subcortical stroke is classically described as distal upper-extremity (UE) predominant, but prevalence data in chronic stroke is limited. Objective: Determine the prevalence of distal predominant UE weakness in…
The emerging field of immunometabolism has underscored the central role of metabolic pathways in orchestrating immune cell function. Far from being passive background processes, metabolic activities actively regulate key immune responses.…
Parkinson disease is a very common neurodegenerative disorder. Patients usually undergo destruction of substantia nigra to develop typical symptoms such as resting tremor, hypokinesia, and rigidity. However, the exact mechanism of Parkinson…
Muscular dystrophy (MD) describes generalized progressive muscular weakness due to the wasting of muscle fibers. The progression of the disease is affected by known immunological and mechanical factors, and possibly other unknown…
Living cells are soft bodies of a characteristic form, but endowed with a capacity for a steady turnover of their structures. Both of these material properties, i.e. recovery of the shape after an external stress has been imposed and…
Many people suffering from skin disorders such as chronic wounds, non-healing ulcers, and diabetic ulcers need skin repair and regeneration. Aside from the diseases listed above, the industry needed a skin rejuvenation system and…
Artificial intelligence models have shown strong potential in acute ischemic stroke imaging, particularly for lesion detection and segmentation using computed tomography and magnetic resonance imaging. However, most existing approaches…