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Acute neuroprotection in numerous human clinical trials has been an abject failure. Major systemic-and procedural-based issues have subsequently been identified in both clinical trials and preclinical animal model experimentation. As well,…
Diabetes affects more than 425 million people worldwide, a scale approaching pandemic proportion. Diabetes represents a major risk factor for stroke, and therefore is actively addressed for stroke prevention. However, how diabetes affects…
English version of abstract A growing number of scientific researches have been demonstrating that olive oil operates a crucial role on the prevention of cardiovascular and tumoral diseases, being related with low mortality and morbidity in…
One of the biggest challenges in medicine is to dampen the pathophysiological stress induced by an episode of ischemia. Such stress, due to various pathological or clinical situations, follows a restriction in blood and oxygen supply to…
Understanding the risk and protective factors associated with Parkinsons disease (PD) is crucial for improving outcomes for patients, individuals at risk, healthcare providers, and healthcare systems. Studying these factors not only…
Oxidative stress, which is one of the main harmful mechanisms of pathologies including is-chemic stroke, contributes to both neurons and endothelial cell damages, leading to vascular lesions. Although many antioxidants have been tested in…
To date, there are no effective treatments for most neurodegenerative diseases. However, certain foods may be associated with these diseases and bring an opportunity to prevent or delay neurodegenerative progression. Our objective is to…
Obesity is a global health concern associated with high morbidity and mortality. Therapeutic strategies include synthetic drugs and surgery, which may entail high costs and serious complications. Plant-based medicinal agents offer an…
Stroke is the second leading cause of death worldwide, and is increasingly prevalent in low- and middle-income countries (LMICs). Timely interventions can significantly influence stroke survivability and the quality of life after treatment.…
Alzheimer disease (AD) is the leading cause of dementia, accounts for 60 to 80 percent cases. Two main factors called beta amyloid plaques and tangles are prime suspects in damaging and killing nerve cells. However, oxidative stress, the…
The negative impact of stroke in society has led to concerted efforts to improve the management and diagnosis of stroke. With an increased synergy between technology and medical diagnosis, caregivers create opportunities for better patient…
Neuroblastoma, is a highly heterogeneous pediatric tumour and is responsible for 15% of pediatric cancer-related deaths. The clinical outcomes can vary from spontaneous regression to high metastatic disease. This extracranial tumour arises…
Lycopene, rich in red, yellow, or orange-colored fruits and vegetables, is the most potent antioxidant among the other carotenoids available in human blood plasma. It is evident that regular lycopene intake can prevent chronic diseases like…
Stroke is a major cause of mortality and long--term disability in the world. Predictive outcome models in stroke are valuable for personalized treatment, rehabilitation planning and in controlled clinical trials. In this paper we design a…
A stroke is defined as a neurologic deficit arising from an interruption in blood supply to the brain. According to the World Health Organization, over 15 million people suffer from strokes annually, of which almost 70% die or are…
Locomotor system disorders affect a vast majority of people at some time in their life bringing pain, functional limitations, social and economic implications. Modern medicine cannot offer prevention and effective treatment for most chronic…
Stroke is one of two main causes of death worldwide. Many individuals suffer from ischemic stroke every year. Only in US more over 700,000 individuals meet ischemic stroke due to blood clot blocking an artery to the brain every year. The…
In the last decades, important progress has been achieved in the understanding of the neurotrophic effects of intermittent fasting (IF), caloric restriction (CR) and exercise. Improved neuroprotection, synaptic plasticity and adult…
Currently, strokes are the leading cause of adult disability in the United States. Traditional treatment and rehabilitation options such as physical therapy and tissue plasminogen activator are limited in their effectiveness and ability to…
The global burden of neurological diseases, the second leading cause of death after heart dis-eases constitutes one of the major challenges of modern medicine. Ayurveda, the traditional Indian medicinal systemenrooted in the Vedic…