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Three-photon (3-P) fluorescence microscopy enables deep in vivo imaging with subcellular resolution, but its performance is fundamentally constrained by the maximum permissible laser power required to avoid tissue heating and photodamage.…

Optics · Physics 2026-03-04 Qi Hu , Jingyu Wang , Huriye Atilgan , Armin Lak , Martin J. Booth

We present a robust objective lens optimized for applications requiring both high numerical aperture (NA) and long front working distance imaging comprised of all commercial-off-the-shelf (COTS) singlet lenses. Unlike traditional designs…

Atomic Physics · Physics 2025-07-22 Jiafeng Cui , Gilles Buchs , Christopher M. Seck

Fourier Ptychographic Microscopy (FPM) is a recent technique to overcome the diffraction limit of a low numerical aperture (NA) objective lens by algorithmic post-processing of several lower resolved images. It can increase the…

We propose a novel design methodology to tackle the multi-surface catadioptric freeform lens design for off-axis road illumination applications based on an ideal source. The lens configuration contains an analytic refractive entrance…

Optics · Physics 2019-06-26 Shili Wei , Zhengbo Zhu , Zichao Fan , Yiming Yan , Donglin Ma

The expansion of viewing angle is a crucial factor in holographic displays implemented with a spatial light modulator having a finite space-bandwidth. The enhanced-NA Fresnel hologram reconstructs a holographic image at an angle larger than…

Optics · Physics 2023-08-24 Byung Gyu Chae

Nano- and microparticles are popular media to enhance optical signals, including fluorescence from a dye proximal to the particle. Here we show that homogeneous, lossless, all-dielectric spheres with diameters in the mesoscale range,…

We report subwavelength-thick, polarization insensitive micro-lenses operating at telecom wavelength with focal spots as small as 0.57 wavelengths and measured focusing efficiency up to 82%. The lens design is based on high contrast…

Optics · Physics 2015-05-20 Amir Arbabi , Yu Horie , Alexander J. Ball , Mahmood Bagheri , Andrei Faraon

Fluorescence microscopy is indispensable in nanoscience and biological sciences. The versatility of labeling target structures with fluorescent dyes permits to visualize structure and function at a subcellular resolution with a wide field…

Fabricating brightly fluorescent layers with nanometric thickness and digitally controlled lateral structuration remains a challenge for next-generation photonic devices, optical calibration standards, and biocompatible interfaces. Here, we…

We demonstrate a sustainable, lithography-free process for generating non fading plasmonic colors with a prototype device that produces a wide range of vivid colors in red, green, and blue (RGB) ([0-1], [0-1], [0-1]) color space from violet…

The explosive growth of computation and energy cost of artificial intelligence has spurred strong interests in new computing modalities as potential alternatives to conventional electronic processors. Photonic processors that execute…

Computer Vision and Pattern Recognition · Computer Science 2024-01-02 Kaixuan Wei , Xiao Li , Johannes Froech , Praneeth Chakravarthula , James Whitehead , Ethan Tseng , Arka Majumdar , Felix Heide

Non-invasive optical focusing inside scattering media is still a big challenge because inhomogeneous media scatter both incoming photons for focusing and outgoing photons for observation. Various approaches, utilizing non-linear…

Optics · Physics 2021-09-17 Dayan Li , Sujit Kumar Sahoo , Huy Quoc Lam , Dong Wang , Cuong Dang

Light-sheet microscopes must compromise between field of view, optical sectioning, resolution, and detection efficiency. High-numerical-aperture (NA) detection objective lenses provide high resolution but their narrow depth of field fails…

Organic photodetectors (OPDs) possess bright prospects in applications of medical imaging and wearable electronics due to the advantages such as low cost, good biocompatibility, and good flexibility. Photomultiplication OPDs (PM-OPDs)…

On-chip integration of highly anisotropic two-dimensional (2D) materials offers new opportunities for realizing high performance polarization selective devices. Obtaining optimized designs for such devices requires extensively sweeping…

Recent advances in optical technology have significantly enhanced the resolution of imaging of living cells, achieving nanometer-scale precision. However, the crowded three-dimensional environment within cells presents a challenge for…

Optics · Physics 2024-11-20 Vahid Nasirimarekani , Zuzana Ditte , Eberhard Bodenschatz

Allying high-resolution with a large field-of-view (FOV) is of great importance in the fields of biology and medicine, but particularly challenging when imaging non-flat living samples such as the human retina. Indeed, high-resolution is…

Artificial nanostructures with ultrafine and deep-subwavelength feature sizes have emerged as a paradigm-shifting platform to advanced light field management, becoming a key building block for high-performance integrated optoelectronics and…

Wide field-of-view (FOV) optics are widely used in various imaging, display, and sensing applications. While conventional wide FOV optics rely on cascading multiple elements to suppress coma and other aberrations, it has recently been…

Optics · Physics 2021-08-25 Fan Yang , Sensong An , Mikhail Y. Shalaginov , Hualiang Zhang , Juejun Hu , Tian Gu

Angular filter refractometry is an optical diagnostic that measures absolute contours of line-integrated density gradient by placing a filter with alternating opaque and transparent zones in the focal plane of a probe beam, which produce…

Plasma Physics · Physics 2023-11-30 P. V. Heuer , D. Haberberger , S. T. Ivancic , C. A. Walsh , J. R. Davies