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Fluorescence microscopy has enabled a dramatic development in modern biology by visualizing biological organisms with micrometer scale resolution. However, due to the diffraction limit, sub-micron/nanometer features are difficult to…

Image and Video Processing · Electrical Eng. & Systems 2021-03-10 Varun Mannam , Yide Zhang , Xiaotong Yuan , Scott Howard

Optical-based nanothermometry represents a transformative approach for precise temperature measurements at the nanoscale, which finds versatile applications across biology, medicine, and electronics. The assembly of ratiometric fluorescent…

Optics · Physics 2025-04-01 Mahshid Iraniparast , Nishant Kumar , Igor Sokolov

We demonstrate a three-dimensional (3D) optical diffraction tomographic technique with optimal frequency combination (OFC-ODT) for the 3D quantitative phase imaging of unlabeled specimens. Three sets of through-focus intensity images are…

Optics · Physics 2018-03-06 Jiaji Li , Qian Chen Jiasong Sun , Jialin Zhang , Junyi Ding , Chao Zuo

Miniaturized, low-cost wavelength detectors are gaining enormous interest as we step into the new age of photonics. Incompatibility with integrated circuits or complex fabrication requirement in most of the conventionally used filters…

Plasmonic materials and metamaterials have been widely utilized to achieve spectral transmission, reflection and absorption filters based on localized or delocalized resonances arising from the interaction of photons with nanostructured…

Optics · Physics 2014-10-30 Zhongyang Li , Serkan Butun , Koray Aydin

Lensless X-ray imaging provides element-specific nanoscale insights into thick samples beyond the reach of conventional light and electron microscopy. Coherent diffraction imaging (CDI) methods, such as ptychographic tomography, can recover…

The orbital angular momentum (OAM) of light provides an unbounded set of orthogonal modes for ultrahigh-capacity optical information processing. However, current OAM detection schemes typically rely on light interference or diffraction,…

The miniaturization of diagnostic devices that exploit optical detection schemes requires the design of light-sources combining small size, high performance for effective excitation of chromophores, and mechanical flexibility for easy…

Dense photonic integration promises to revolutionize optical computing and communications. However, efforts towards this goal face unacceptable attenuation of light caused by surface roughness in microscopic devices. Here we address this…

Optics · Physics 2015-05-30 M. Sumetsky , J. M. Fini

Optical parametric oscillation (OPO) in a microresonator is promising as an efficient and scalable approach to on-chip coherent visible light generation. However, so far only red light at < 420 THz (near the edge of the visible band) has…

Optics · Physics 2022-07-21 Xiyuan Lu , Gregory Moille , Ashutosh Rao , Daron Westly , Kartik Srinivasan

Optical metasurfaces have been heralded as the platform to integrate multiple functionalities in a compact form-factor, potentially replacing bulky components. A central stepping stone towards realizing this promise is the demonstration of…

Optical fibers are crucial for guiding light in various sensing applications. Especially for quantum sensors such as the nitrogen-vacancy (NV) center in diamond, they enable light control and device miniaturization. However, fluorescence…

Free-space optical communications with moving targets, such as satellite terminals, demand ultrafast wavefront sensing and correction. This is typically addressed using a Shack-Hartmann sensor, which pairs a high-speed camera with a lenslet…

Fluorescent Optical Tomography (FOT) is a new bio-medical imaging method with wider industrial applications. It is currently intensely researched since it is very precise and with no side effects for humans, as it uses non-ionising red and…

Analysis of PDEs · Mathematics 2019-10-29 Nikos Katzourakis

Total internal reflection fluorescence microscopy (TIRF) has enabled low-background, live-cell friendly imaging of cell surfaces and other thin samples thanks to the shallow penetration of the evanescent light field into the sample. The…

Selective plane illumination microscopy (SPIM), also known as light sheet fluorescence microscopy, provides high specificity through fluorescence labeling. However, it lacks complementary structural information from the surrounding context,…

Optics · Physics 2024-12-19 Rui Ma , Olga Lyraki , Daniel Wehner , Jochen Guck

The wavelength and state of polarization (SOP) are fundamental properties of an optical field which are essential for applications in optical communications, imaging and other fields. However, it is challenging for existing spectrometers…

Optics · Physics 2025-02-25 Yuxuan Xiong , Hao Wu , Mingming Zhang , Yucheng Yao , Ming Tang

Aberrations limit scanning fluorescence microscopy when imaging in scattering materials such as biological tissue. Model-based approaches for adaptive optics take advantage of a computational model of the optical setup. Such models can be…

Optics · Physics 2021-07-07 Ivan Vishniakou , Johannes D. Seelig

The realization of all-optical logic gates (AOLGs) is important for advancing photonic integrated circuit (PIC) design and optical data communication. Various photonic structures and design techniques, including two-dimensional photonic…

Dynamic full-field optical coherence microscopy (d-FF-OCM) is a label-free imaging technique that captures intrinsic subcellular motions to generate functional contrast. This dynamic approach yields images with fluorescence-like contrast,…

Optics · Physics 2025-08-06 Erikas Tarvydas , Austeja Treciokaite , Egidijus Auksorius
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