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Alzheimer's Disease and normal aging are both characterized by brain atrophy. The question of whether AD-related brain atrophy represents accelerated aging or a neurodegeneration process distinct from that in normal aging remains…

Computer Vision and Pattern Recognition · Computer Science 2025-04-08 Jingru Fu , Daniel Ferreira , Örjan Smedby , Rodrigo Moreno

Reliable segmentation of anatomical tissues of human head is a major step in several clinical applications such as brain mapping, surgery planning and associated computational simulation studies. Segmentation is based on identifying…

Computer Vision and Pattern Recognition · Computer Science 2023-09-14 Essam A. Rashed , Mohammad al-Shatouri , Ilkka Laakso , Akimasa Hirata

Accurate estimation of biological brain age from three dimensional (3D) T$_1$-weighted magnetic resonance imaging (MRI) is a critical imaging biomarker for identifying accelerated aging associated with neurodegenerative diseases. Effective…

Image and Video Processing · Electrical Eng. & Systems 2025-08-05 Mehreen Kanwal , Yunsik Son

We investigate numerically the dynamics of three different spin models in the aging regime. Each of these models is meant to be representative of a distinct class of aging behavior: coarsening systems, discontinuous spin glasses, and…

Disordered Systems and Neural Networks · Physics 2009-11-10 Andrea Montanari , Federico Ricci-Tersenghi

In the paper, we present an approach for learning a single model that universally segments 33 anatomical structures, including vertebrae, pelvic bones, and abdominal organs. Our model building has to address the following challenges.…

Image and Video Processing · Electrical Eng. & Systems 2022-03-07 Pengbo Liu , Yang Deng , Ce Wang , Yuan Hui , Qian Li , Jun Li , Shiwei Luo , Mengke Sun , Quan Quan , Shuxin Yang , You Hao , Honghu Xiao , Chunpeng Zhao , Xinbao Wu , S. Kevin Zhou

Alzheimer's Disease (AD) is a neurodegenerative disease that is one of the significant causes of death in the elderly population. Many deep learning techniques have been proposed to diagnose AD using Magnetic Resonance Imaging (MRI) scans.…

Image and Video Processing · Electrical Eng. & Systems 2022-07-05 A. H. Rashid , A. Gupta , J. Gupta , M. Tanveer

Bone age assessment (BAA) is a standard method for determining the age difference between skeletal and chronological age. Manual processes are complicated and necessitate the expertise of experts. This is where deep learning comes into…

Image and Video Processing · Electrical Eng. & Systems 2022-07-22 Aravinda Raman , Sameena Pathan , Tanweer Ali

Schizophrenia (SZ) is a mental disorder that typically emerges in late adolescence or early adulthood. It reduces the life expectancy of patients by 15 years. Abnormal behavior, perception of emotions, social relationships, and reality…

Spine segmentation, based on ultrasound volume projection imaging (VPI), plays a vital role for intelligent scoliosis diagnosis in clinical applications. However, this task faces several significant challenges. Firstly, the global…

Computer Vision and Pattern Recognition · Computer Science 2025-10-31 Hao Xie , Zixun Huang , Yushen Zuo , Yakun Ju , Frank H. F. Leung , N. F. Law , Kin-Man Lam , Yong-Ping Zheng , Sai Ho Ling

Neuroimaging biomarkers that distinguish between typical brain aging and Alzheimer's disease (AD) are valuable for determining how much each contributes to cognitive decline. Machine learning models can derive multi-variate brain change…

With populations ageing, the number of people with dementia worldwide is expected to triple to 152 million by 2050. Seventy percent of cases are due to Alzheimer's disease (AD) pathology and there is a 10-20 year 'pre-clinical' period…

Artificial Intelligence · Computer Science 2021-04-30 Renjie Li , Xinyi Wang , Katherine Lawler , Saurabh Garg , Quan Bai , Jane Alty

Magnetic Resonance Images (MRIs) are extremely used in the medical field to detect and better understand diseases. In order to fasten automatic processing of scans and enhance medical research, this project focuses on automatically…

Image and Video Processing · Electrical Eng. & Systems 2020-01-16 Antoine Delplace

Age prediction using brain imaging, such as MRIs, has achieved promising results, with several studies identifying the model's residual as a potential biomarker for chronic disease states. In this study, we developed a brain age predictive…

Machine Learning · Computer Science 2025-04-22 Shahrzad Jamshidi , Arthur Bousquet , Sugata Banerji , Mark F. Conneely , Bita Aslrousta

Early and accurate diagnosis of Alzheimer Disease is critical for effective clinical intervention, particularly in distinguishing it from Mild Cognitive Impairment, a prodromal stage marked by subtle structural changes. In this study, we…

Image and Video Processing · Electrical Eng. & Systems 2025-10-08 Fahad Mostafa , Kannon Hossain , Hafiz Khan

Osteoporosis is a common condition that increases fracture risk, especially in older adults. Early diagnosis is vital for preventing fractures, reducing treatment costs, and preserving mobility. However, healthcare providers face challenges…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Mehdi Hosseini Chagahi , Saeed Mohammadi Dashtaki , Niloufar Delfan , Nadia Mohammadi , Farshid Rostami Pouria , Behzad Moshiri , Md. Jalil Piran , Oliver Faust

We propose an interpretable 3D Grid-Attention deep neural network that can accurately predict a person's age and whether they have Alzheimer's disease (AD) from a structural brain MRI scan. Building on a 3D convolutional neural network, we…

Tissues and Organs · Quantitative Biology 2020-11-19 Pradeep Lam , Alyssa H. Zhu , Iyad Ba Gari , Neda Jahanshad , Paul M. Thompson

Scoliosis is a three-dimensional spinal deformity, which may lead to abnormal morphologies, such as thoracic deformity, and pelvic tilt. Severe patients may suffer from nerve damage and urinary abnormalities. At present, the number of…

Image and Video Processing · Electrical Eng. & Systems 2024-09-24 Zhenlin Zhang , Lixin Pu , Ang Li , Jun Zhang , Xianjie Li , Jipeng Fan

Age-related macular degeneration (AMD) is a major cause of blindness in older adults, severely affecting vision and quality of life. Despite advances in understanding AMD, the molecular factors driving the severity of subretinal scarring…

Genomics · Quantitative Biology 2024-09-10 Kuan Yan , Yue Zeng , Dai Shi , Ting Zhang , Dmytro Matsypura , Mark C. Gillies , Ling Zhu , Junbin Gao

Simulating prospective magnetic resonance imaging (MRI) scans from a given individual brain image is challenging, as it requires accounting for canonical changes in aging and/or disease progression while also considering the individual…

Computer Vision and Pattern Recognition · Computer Science 2025-06-23 Jingru Fu , Yuqi Zheng , Neel Dey , Daniel Ferreira , Rodrigo Moreno

Vertebrae localization, segmentation and identification in CT images is key to numerous clinical applications. While deep learning strategies have brought to this field significant improvements over recent years, transitional and…

Image and Video Processing · Electrical Eng. & Systems 2022-06-27 Di Meng , Edmond Boyer , Sergi Pujades