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Risk stratification is a key tool in clinical decision-making, yet current approaches often fail to translate sophisticated survival analysis into actionable clinical criteria. We present a novel method for unsupervised machine learning…

Recent advances in computational pathology have led to the emergence of numerous foundation models. These models typically rely on general-purpose encoders with multi-instance learning for whole slide image (WSI) classification or apply…

Computer Vision and Pattern Recognition · Computer Science 2025-10-29 Yuxuan Sun , Yixuan Si , Chenglu Zhu , Kai Zhang , Zhongyi Shui , Bowen Ding , Tao Lin , Lin Yang

Diagnosing lung cancer typically involves physicians identifying lung nodules in Computed tomography (CT) scans and generating diagnostic reports based on their morphological features and medical expertise. Although advancements have been…

Computer Vision and Pattern Recognition · Computer Science 2025-11-27 Cheng Yang , Hui Jin , Xinlei Yu , Zhipeng Wang , Yaoqun Liu , Fenglei Fan , Dajiang Lei , Gangyong Jia , Changmiao Wang , Ruiquan Ge

For predicting cancer survival outcomes, standard approaches in clinical research are often based on two main modalities: pathology images for observing cell morphology features, and genomic (e.g., bulk RNA-seq) for quantifying gene…

Computer Vision and Pattern Recognition · Computer Science 2024-03-19 Hongxiao Wang , Yang Yang , Zhuo Zhao , Pengfei Gu , Nishchal Sapkota , Danny Z. Chen

Target Safety Assessment (TSA) requires systematic integration of heterogeneous evidence, including genetic, transcriptomic, target homology, pharmacological, and clinical data, to evaluate potential safety liabilities of therapeutic…

Computation and Language · Computer Science 2026-05-11 Xiaochen Zheng , Zhiwen Jiang , Melanie Guerard , Klas Hatje , Tatyana Doktorova

LLM-based multimodal emotion recognition relies on static parametric memory and often hallucinates when interpreting nuanced affective states. In this paper, given that single-round retrieval-augmented generation is highly susceptible to…

Computer Vision and Pattern Recognition · Computer Science 2026-04-15 Zeheng Wang , Zitong Yu , Yijie Zhu , Bo Zhao , Haochen Liang , Taorui Wang , Wei Xia , Jiayu Zhang , Zhishu Liu , Hui Ma , Fei Ma , Qi Tian

Agentic systems offer a potential path to solve complex clinical tasks through collaboration among specialized agents, augmented by tool use and external knowledge bases. Nevertheless, for chest X-ray (CXR) interpretation, prevailing…

Multiagent Systems · Computer Science 2026-04-16 Kai Zhang , Corey D Barrett , Jangwon Kim , Lichao Sun , Tara Taghavi , Krishnaram Kenthapadi

Although numerous strategies have recently been proposed to enhance the autonomous interaction capabilities of multimodal agents in graphical user interface (GUI), their reliability remains limited when faced with complex or out-of-domain…

Computation and Language · Computer Science 2025-10-06 Pengzhou Cheng , Lingzhong Dong , Zeng Wu , Zongru Wu , Xiangru Tang , Chengwei Qin , Zhuosheng Zhang , Gongshen Liu

Accurately predicting the survival rate of cancer patients is crucial for aiding clinicians in planning appropriate treatment, reducing cancer-related medical expenses, and significantly enhancing patients' quality of life. Multimodal…

Computer Vision and Pattern Recognition · Computer Science 2024-03-15 Liangrui Pan , Yijun Peng , Yan Li , Xiang Wang , Wenjuan Liu , Liwen Xu , Qingchun Liang , Shaoliang Peng

The accurate prediction of survival times for patients with severe diseases remains a critical challenge despite recent advances in artificial intelligence. This study introduces "SurvTimeSurvival: Survival Analysis On Patients With…

Machine Learning · Computer Science 2023-11-17 Hung Le , Ong Eng-Jon , Bober Miroslaw

Diagnosing diseases through histopathology whole slide images (WSIs) is fundamental in modern pathology but is challenged by the gigapixel scale and complexity of WSIs. Trained histopathologists overcome this challenge by navigating the…

Computer Vision and Pattern Recognition · Computer Science 2025-02-14 Fatemeh Ghezloo , Mehmet Saygin Seyfioglu , Rustin Soraki , Wisdom O. Ikezogwo , Beibin Li , Tejoram Vivekanandan , Joann G. Elmore , Ranjay Krishna , Linda Shapiro

Research agents have recently achieved significant progress in information seeking and synthesis across heterogeneous textual and visual sources. In this paper, we introduce MuSEAgent, a multimodal reasoning agent that enhances…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Shijian Wang , Jiarui Jin , Runhao Fu , Zexuan Yan , Xingjian Wang , Mengkang Hu , Eric Wang , Xiaoxi Li , Kangning Zhang , Li Yao , Wenxiang Jiao , Xuelian Cheng , Yuan Lu , Zongyuan Ge

Survival analysis (SA) models have been widely studied in mining electronic health records (EHRs), particularly in forecasting the risk of critical conditions for prioritizing high-risk patients. However, their vulnerability to adversarial…

Machine Learning · Computer Science 2024-12-30 Mohsen Nayebi Kerdabadi , Arya Hadizadeh Moghaddam , Bin Liu , Mei Liu , Zijun Yao

Cancer prognosis is a critical task that involves predicting patient outcomes and survival rates. To enhance prediction accuracy, previous studies have integrated diverse data modalities, such as clinical notes, medical images, and genomic…

Machine Learning · Computer Science 2025-02-04 Jie Peng , Shuang Zhou , Longwei Yang , Yiran Song , Mohan Zhang , Kaixiong Zhou , Feng Xie , Mingquan Lin , Rui Zhang , Tianlong Chen

Large Language Model (LLM)-based agents have recently shown impressive capabilities in complex reasoning and tool use via multi-step interactions with their environments. While these agents have the potential to tackle complicated tasks,…

Artificial Intelligence · Computer Science 2025-11-04 Jiaye Lin , Yifu Guo , Yuzhen Han , Sen Hu , Ziyi Ni , Licheng Wang , Mingguang Chen , Hongzhang Liu , Ronghao Chen , Yangfan He , Daxin Jiang , Binxing Jiao , Chen Hu , Huacan Wang

Survival prediction, utilizing pathological images and genomic profiles, is increasingly important in cancer analysis and prognosis. Despite significant progress, precise survival analysis still faces two main challenges: (1) The massive…

Image and Video Processing · Electrical Eng. & Systems 2024-06-26 Songhan Jiang , Zhengyu Gan , Linghan Cai , Yifeng Wang , Yongbing Zhang

Renal cell carcinoma represents a significant global health challenge with a low survival rate. This research aimed to devise a comprehensive deep-learning model capable of predicting survival probabilities in patients with renal cell…

Computer Vision and Pattern Recognition · Computer Science 2023-07-10 Maryamalsadat Mahootiha , Hemin Ali Qadir , Jacob Bergsland , Ilangko Balasingham

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is particularly challenging due to the different nature of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Guillaume Jaume , Anurag Vaidya , Richard Chen , Drew Williamson , Paul Liang , Faisal Mahmood

Identifying associations between imaging phenotypes, disease risk factors, and clinical outcomes is essential for understanding disease mechanisms. However, traditional approaches rely on human-driven hypothesis testing and selection of…

Artificial Intelligence · Computer Science 2025-09-09 Weitong Zhang , Mengyun Qiao , Chengqi Zang , Steven Niederer , Paul M Matthews , Wenjia Bai , Bernhard Kainz

Therapeutic decision-making in clinical medicine constitutes a high-stakes domain in which AI guidance interacts with complex interactions among patient characteristics, disease processes, and pharmacological agents. Tasks such as drug…

Artificial Intelligence · Computer Science 2025-12-15 Tim Cofala , Christian Kalfar , Jingge Xiao , Johanna Schrader , Michelle Tang , Wolfgang Nejdl