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The diagnosis and prognosis of cancer are typically based on multi-modal clinical data, including histology images and genomic data, due to the complex pathogenesis and high heterogeneity. Despite the advancements in digital pathology and…

Quantitative Methods · Quantitative Biology 2024-04-15 Zeyu Zhang , Yuanshen Zhao , Jingxian Duan , Yaou Liu , Hairong Zheng , Dong Liang , Zhenyu Zhang , Zhi-Cheng Li

Spatial transcriptomics enables spatial gene expression profiling, motivating computational models that capture spatially conditioned regulatory relationships. We introduce SAGE-FM, a lightweight spatial transcriptomics foundation model…

Machine Learning · Computer Science 2026-01-23 Xianghao Zhan , Jingyu Xu , Yuanning Zheng , Zinaida Good , Olivier Gevaert

Deep learning has proven to successfully learn variations in tissue and cell morphology. Training of such models typically relies on expensive manual annotations. Here we conjecture that spatially resolved gene expression, e.i., the…

Quantitative Methods · Quantitative Biology 2023-12-11 Axel Andersson , Gabriele Partel , Leslie Solorzano , Carolina Wählby

Medication mistaking is one of the risks that can result in unpredictable consequences for patients. To mitigate this risk, we develop an automatic system that correctly identifies pill-prescription from mobile images. Specifically, we…

Computer Vision and Pattern Recognition · Computer Science 2022-09-05 Trung Thanh Nguyen , Hoang Dang Nguyen , Thanh Hung Nguyen , Huy Hieu Pham , Ichiro Ide , Phi Le Nguyen

Integrating whole-slide images (WSIs) and bulk transcriptomics for predicting patient survival can improve our understanding of patient prognosis. However, this multimodal task is particularly challenging due to the different nature of…

Computer Vision and Pattern Recognition · Computer Science 2024-04-16 Guillaume Jaume , Anurag Vaidya , Richard Chen , Drew Williamson , Paul Liang , Faisal Mahmood

Vision-language models have shown strong performance, but they often generalize poorly to specialized domains. While semi-supervised vision-language learning mitigates this limitation by leveraging a small set of labeled image-text pairs…

Computer Vision and Pattern Recognition · Computer Science 2026-04-30 Junwon You , Mihyun Jang , Sangwoo Mo , Jae-Hun Jung

Human perception integrates multiple modalities, such as vision, hearing, and language, into a unified understanding of the surrounding reality. While recent multimodal models have achieved significant progress by aligning pairs of…

Computer Vision and Pattern Recognition · Computer Science 2025-02-13 Giordano Cicchetti , Eleonora Grassucci , Luigi Sigillo , Danilo Comminiello

In the field of computational histopathology, both whole slide images (WSIs) and diagnostic captions provide valuable insights for making diagnostic decisions. However, aligning WSIs with diagnostic captions presents a significant…

Computer Vision and Pattern Recognition · Computer Science 2025-03-18 Qifeng Zhou , Wenliang Zhong , Yuzhi Guo , Michael Xiao , Hehuan Ma , Junzhou Huang

Multi-modal semantic understanding requires integrating information from different modalities to extract users' real intention behind words. Most previous work applies a dual-encoder structure to separately encode image and text, but fails…

Computation and Language · Computer Science 2024-03-12 Ming Zhang , Ke Chang , Yunfang Wu

Predicting the response of a patient to a cancer treatment is of high interest. Nonetheless, this task is still challenging from a medical point of view due to the complexity of the interaction between the patient organism and the…

Computer Vision and Pattern Recognition · Computer Science 2024-08-09 Bilel Guetarni , Feryal Windal , Halim Benhabiles , Mahfoud Chaibi , Romain Dubois , Emmanuelle Leteurtre , Dominique Collard

We propose a novel computational framework leveraging hypergraph theory to analyse cancer stem cell markers (CSCMs) across multiple organs. Hypergraphs provide a robust representation of CSCM co-expression patterns, capturing their complex…

Biological Physics · Physics 2025-08-01 David H. Margarit , Gustavo Paccosi , Marcela V. Reale , Lilia M. Romanelli

Identification and counting of cells and mitotic figures is a standard task in diagnostic histopathology. Due to the large overall cell count on histological slides and the potential sparse prevalence of some relevant cell types or mitotic…

Computer Vision and Pattern Recognition · Computer Science 2017-09-08 Marc Aubreville , Maximilian Krappmann , Christof Bertram , Robert Klopfleisch , Andreas Maier

This paper presents a novel unsupervised domain adaptation framework, called Synergistic Image and Feature Adaptation (SIFA), to effectively tackle the problem of domain shift. Domain adaptation has become an important and hot topic in…

Computer Vision and Pattern Recognition · Computer Science 2019-06-19 Cheng Chen , Qi Dou , Hao Chen , Jing Qin , Pheng-Ann Heng

This paper demonstrates that spatial information can be used to learn interpretable representations in medical images using Self-Supervised Learning (SSL). Our proposed method, ISImed, is based on the observation that medical images exhibit…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Nabil Jabareen , Dongsheng Yuan , Sören Lukassen

Video-based pretraining offers immense potential for learning strong visual representations on an unprecedented scale. Recently, masked video modeling methods have shown promising scalability, yet fall short in capturing higher-level…

Computer Vision and Pattern Recognition · Computer Science 2024-07-23 Mohammadreza Salehi , Michael Dorkenwald , Fida Mohammad Thoker , Efstratios Gavves , Cees G. M. Snoek , Yuki M. Asano

The classification of medical images is a pivotal aspect of disease diagnosis, often enhanced by deep learning techniques. However, traditional approaches typically focus on unimodal medical image data, neglecting the integration of diverse…

Image and Video Processing · Electrical Eng. & Systems 2025-11-11 Jun-En Ding , Chien-Chin Hsu , Chi-Hsiang Chu , Shuqiang Wang , Feng Liu

Domain adaptation is an attractive approach given the availability of a large amount of labeled data with similar properties but different domains. It is effective in image classification tasks where obtaining sufficient label data is…

Computer Vision and Pattern Recognition · Computer Science 2022-09-28 Yeganeh Madadi , Vahid Seydi , Jian Sun , Edward Chaum , Siamak Yousefi

Most existing cross-modal retrieval methods employ two-stream encoders with different architectures for images and texts, \textit{e.g.}, CNN for images and RNN/Transformer for texts. Such discrepancy in architectures may induce different…

Computer Vision and Pattern Recognition · Computer Science 2023-08-09 Yi Bin , Haoxuan Li , Yahui Xu , Xing Xu , Yang Yang , Heng Tao Shen

The development of computational pathology lies in the consensus that pathological characteristics of tumors are significant guidance for cancer diagnostics. Most existing research focuses on the inner-contextual information within each WSI…

Computer Vision and Pattern Recognition · Computer Science 2024-10-15 Jun Shi , Tong Shu , Zhiguo Jiang , Wei Wang , Haibo Wu , Yushan Zheng

In pathology, tissue samples are assessed using multiple staining techniques to enhance contrast in unique histologic features. In this paper, we introduce a multimodal CNN-GNN based graph fusion approach that leverages complementary…

Image and Video Processing · Electrical Eng. & Systems 2022-04-28 Chaitanya Dwivedi , Shima Nofallah , Maryam Pouryahya , Janani Iyer , Kenneth Leidal , Chuhan Chung , Timothy Watkins , Andrew Billin , Robert Myers , John Abel , Ali Behrooz