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Multi-instance learning is common for computer vision tasks, especially in biomedical image processing. Traditional methods for multi-instance learning focus on designing feature aggregation methods and multi-instance classifiers, where the…

Computer Vision and Pattern Recognition · Computer Science 2021-03-18 Yanlun Tu , Houchao Lei , Wei Long , Yang Yang

Contrastive learning has emerged as a powerful tool for graph representation learning. However, most contrastive learning methods learn features of graphs with fixed coarse-grained scale, which might underestimate either local or global…

Machine Learning · Computer Science 2022-10-24 Jun Wang , Weixun Li , Changyu Hou , Xin Tang , Yixuan Qiao , Rui Fang , Pengyong Li , Peng Gao , Guotong Xie

Heterogeneous graph pre-training (HGP) has demonstrated remarkable performance across various domains. However, the issue of heterophily in real-world heterogeneous graphs (HGs) has been largely overlooked. To bridge this research gap, we…

Machine Learning · Computer Science 2025-01-16 Haosen Wang , Chenglong Shi , Can Xu , Surong Yan , Pan Tang

Multi-modal learning plays a crucial role in cancer diagnosis and prognosis. Current deep learning based multi-modal approaches are often limited by their abilities to model the complex correlations between genomics and histology data,…

Image and Video Processing · Electrical Eng. & Systems 2024-06-21 Yupei Zhang , Xiaofei Wang , Fangliangzi Meng , Jin Tang , Chao Li

Table understanding (TU) has achieved promising advancements, but it faces the challenges of the scarcity of manually labeled tables and the presence of complex table structures.To address these challenges, we propose HGT, a framework with…

Computation and Language · Computer Science 2024-12-17 Rihui Jin , Yu Li , Guilin Qi , Nan Hu , Yuan-Fang Li , Jiaoyan Chen , Jianan Wang , Yongrui Chen , Dehai Min , Sheng Bi

The enhanced representational power and broad applicability of deep learning models have attracted significant interest from the research community in recent years. However, these models often struggle to perform effectively under domain…

Computer Vision and Pattern Recognition · Computer Science 2024-12-17 Ba Hung Ngo , Doanh C. Bui , Nhat-Tuong Do-Tran , Tae Jong Choi

Pretraining on large-scale, in-domain datasets grants histopathology foundation models (FM) the ability to learn task-agnostic data representations, enhancing transfer learning on downstream tasks. In computational pathology, automated…

Computer Vision and Pattern Recognition · Computer Science 2025-07-22 Pablo Meseguer , Rocío del Amor , Valery Naranjo

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting…

Computer Vision and Pattern Recognition · Computer Science 2026-02-26 Eric Zimmermann , Julian Viret , Michal Zelechowski , James Brian Hall , Neil Tenenholtz , Adam Casson , George Shaikovski , Eugene Vorontsov , Siqi Liu , Kristen A Severson

In semi-supervised segmentation, capturing meaningful semantic structures from unlabeled data is essential. This is particularly challenging in histopathology image analysis, where objects are densely distributed. To address this issue, we…

Computer Vision and Pattern Recognition · Computer Science 2025-10-03 Meilong Xu , Xiaoling Hu , Shahira Abousamra , Chen Li , Chao Chen

Spatial transcriptomics (ST) enables simultaneous mapping of tissue morphology and spatially resolved gene expression, offering unique opportunities to study tumor microenvironment heterogeneity. Here, we introduce a computational framework…

Quantitative Methods · Quantitative Biology 2026-04-27 Ling Liao , Changhuei Yang , Maxim Artyomov , Mark Watson , Adam Kepecs , Haowen Zhou , Alexey Sergushichev , Richard Cote

Spatial transcriptomics has revolutionized tissue analysis by simultaneously mapping gene expression, spatial topography, and histological context across consecutive tissue sections, enabling systematic investigation of spatial…

Applications · Statistics 2025-10-24 Meng Zhou , Shuangge Ma , Mengyun Wu

Hyperspectral images (HSI) clustering is an important but challenging task. The state-of-the-art (SOTA) methods usually rely on superpixels, however, they do not fully utilize the spatial and spectral information in HSI 3-D structure, and…

Computer Vision and Pattern Recognition · Computer Science 2025-09-23 Jianhan Qi , Yuheng Jia , Hui Liu , Junhui Hou

We investigate node representation learning on text-attributed graphs (TAGs), where nodes are associated with text information. Although recent studies on graph neural networks (GNNs) and pretrained language models (PLMs) have exhibited…

Information Retrieval · Computer Science 2024-04-22 Peiyan Zhang , Chaozhuo Li , Liying Kang , Feiran Huang , Senzhang Wang , Xing Xie , Sunghun Kim

Self-supervised learning (SSL) has driven major advances in computational pathology by enabling the learning of rich representations from histopathology data. Yet, tissue analysis alone may fall short in capturing broader molecular…

Machine Learning · Computer Science 2025-12-17 Lucas Robinet , Ahmad Berjaoui , Elizabeth Cohen-Jonathan Moyal

Self-supervised Learning (SSL) has become a powerful paradigm for representation learning without manual annotations. However, most existing frameworks focus on global alignment and struggle to capture the hierarchical, multi-scale lesion…

Computer Vision and Pattern Recognition · Computer Science 2025-12-17 Abdullah Al Mamun , Miaohua Zhang , David Ahmedt-Aristizabal , Zeeshan Hayder , Mohammad Awrangjeb

For many patients, current ovarian cancer treatments offer limited clinical benefit. For some therapies, it is not possible to predict patients' responses, potentially exposing them to the adverse effects of treatment without any…

Image and Video Processing · Electrical Eng. & Systems 2023-10-20 Jack Breen , Katie Allen , Kieran Zucker , Geoff Hall , Nishant Ravikumar , Nicolas M. Orsi

High-dimensional and complex spectral structures make the clustering of hyperspectral images (HSI) a challenging task. Subspace clustering is an effective approach for addressing this problem. However, current subspace clustering algorithms…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Renxiang Guan , Zihao Li , Xianju Li , Chang Tang , Ruyi Feng

Spatial Transcriptomics (ST) reveals the spatial distribution of gene expression in tissues, offering critical insights into biological processes and disease mechanisms. However, the high cost, limited coverage, and technical complexity of…

Computer Vision and Pattern Recognition · Computer Science 2025-04-22 Yi Niu , Jiashuai Liu , Yingkang Zhan , Jiangbo Shi , Di Zhang , Marika Reinius , Ines Machado , Mireia Crispin-Ortuzar , Jialun Wu , Chen Li , Zeyu Gao

In Computational Pathology (CPath), the introduction of Vision-Language Models (VLMs) has opened new avenues for research, focusing primarily on aligning image-text pairs at a single magnification level. However, this approach might not be…

Computer Vision and Pattern Recognition · Computer Science 2025-04-29 Shahad Albastaki , Anabia Sohail , Iyyakutti Iyappan Ganapathi , Basit Alawode , Asim Khan , Sajid Javed , Naoufel Werghi , Mohammed Bennamoun , Arif Mahmood

This paper presents a novel hierarchical alignment model (HAM) that learns multi-granularity visual and linguistic representations in an end-to-end manner. We extract key points and proposal points to model 3D contexts and instances, and…

Computer Vision and Pattern Recognition · Computer Science 2023-06-12 Jiaming Chen , Weixin Luo , Ran Song , Xiaolin Wei , Lin Ma , Wei Zhang