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Recent progress in neuroscience to image and investigate brain function has been made possible by impressive developments in optogenetic and opto-molecular tools. Such research requires advances in optical techniques for the delivery of…

While stress visualization within 3-dimensional particles would greatly advance our understanding of the behaviors of complex particles, traditional photoelastic methods suffer from a lack of available technology for producing suitable…

Multi-photon lithography has emerged as a powerful tool for photonic integration, allowing to complement planar photonic circuits by 3D-printed freeform structures such as waveguides or micro-optical elements. These structures can be…

Recent developments in photonics include efficient nanoscale optoelectronic components and novel methods for sub-wavelength light manipulation. Here, we explore the potential offered by such devices as a substrate for neuromorphic…

Mesoscale and Nanoscale Physics · Physics 2020-10-15 David O. Winge , Steven Limpert , Heiner Linke , Magnus T. Borgström , Barbara Webb , Stanley Heinze , Anders Mikkelsen

Stimulation of specific neurons expressing opsins in a targeted region to manipulate brain function has proved to be a powerful tool in neuroscience. However, the use of visible light for optogenetic stimulation is invasive due to low…

Additive manufacturing has revolutionized the building of materials direct from design, allowing high resolution rapid prototyping in complex 3D designs with many materials. 3D printing hasenabled high strength damage-tolerant structures,…

Applied Physics · Physics 2020-07-17 Vladimir Egorov , Umair Gulzar , Yan Zhang , Siobhán Breen , Colm O'Dwyer

We report optical brain imaging using a semi-transparent organic light-emitting diode (OLED) based on the orange light-emitting polymer (LEP) Livilux PDO-124. The OLED serves as a compact, extended light source which is capable of uniformly…

Three-dimensional (3D) nano-printing via two-photon polymerization offers unparalleled design flexibility and precision, thereby enabling rapid prototyping of advanced micro-optical elements and systems, including hybrid achromats,…

Optics · Physics 2026-02-25 Florian Lux , Aybuke Calikoglu , Çağlar Ataman

Cathodoluminescence, i.e. the radiation caused by the interaction of high-energy electron beams with matter, has gained a major interest in the analysis of minerals, semiconductors, and plasmonic resonances in nanoparticles. This radiation…

Neural probes are in vivo invasive devices that combine electrophysiology and optogenetics to gain insight into how the brain operates, down to the single neuron and its network activity. Their integration of stimulation sites and sensors…

Light-based 3D printing, which relies on photocurable resins, has shown the capability to produce complex geometries with high resolution and fidelity. Tomographic Volumetric Additive Manufacturing (TVAM) employs a digital micromirror…

Optics · Physics 2025-06-04 Maria Isabel Álvarez-Castaño , Ye Pu , Christophe Moser

Deep learning-based segmentation techniques have shown remarkable performance in brain segmentation, yet their success hinges on the availability of extensive labeled training data. Acquiring such vast datasets, however, poses a significant…

Computer Vision and Pattern Recognition · Computer Science 2024-07-18 Jihoon Cho , Suhyun Ahn , Beomju Kim , Hyungjoon Bae , Xiaofeng Liu , Fangxu Xing , Kyungeun Lee , Georges Elfakhri , Van Wedeen , Jonghye Woo , Jinah Park

A wide range of modern science and engineering applications are formulated as optimization problems with a system of partial differential equations (PDEs) as constraints. These PDE-constrained optimization problems are typically solved in a…

Artificial Intelligence · Computer Science 2021-04-28 Yuyu Zhang , Heng Chi , Binghong Chen , Tsz Ling Elaine Tang , Lucia Mirabella , Le Song , Glaucio H. Paulino

Neuromorphic computing-modelled after the functionality and efficiency of biological neural systems-offers promising new directions for advancing artificial intelligence and computational models. Photonic techniques for neuromorphic…

Clinical trials previously demonstrated the notable capacity to elicit visual percepts in blind patients affected with retinal diseases by electrically stimulating the remaining neurons on the retina. However, these implants restored very…

The lack of labeled datasets in 3D vision for surgical scenes inhibits the development of robust 3D reconstruction algorithms in the medical domain. Despite the popularity of Neural Radiance Fields and 3D Gaussian Splatting in the general…

Computer Vision and Pattern Recognition · Computer Science 2025-03-03 John J. Han , Jie Ying Wu

Advanced photonic tools may enable researchers and clinicians to visualize, track, control and manipulate biological processes at the single-cell level in space and time. Biological systems are complex and highly organized on both spatial…

Optics · Physics 2021-11-30 Alina Karabchevsky , Tal Elbaz , Aviad Katiyi , Ofer Prager , Alon Friedman

The efficiency of photo-conductive switches, which continue to be used for the generation and detection of THz waves, has been overlooked for a long time. The so far 'optics-dominated' devices are making their way through to new and…

Applied Physics · Physics 2020-11-10 Giorgos Georgiou , Clément Geffroy , Christopher Bäuerle , Jean-François Roux

A novel beam profiler based on microstructured scintillation resin is presented. The detector consists of a bundle of waveguides, with an active area of 30 x 30 mm$^2$ and a pitch of 400 $\mu$m, obtained by molding a scintillating resin…

Photonic computing using chalcogenide phase-change materials (PCMs) is under active development for energy-efficient artificial intelligence (AI) applications. A key requirement is to enable as many optically programmable levels per device…

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