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Myocardial Contrast Echocardiography (MCE) with micro-bubble contrast agent enables myocardial perfusion quantification which is invaluable for the early detection of coronary artery diseases. In this paper, we proposed a new segmentation…

Computer Vision and Pattern Recognition · Computer Science 2018-06-21 Yuanwei Li , Chin Pang Ho , Navtej Chahal , Roxy Senior , Meng-Xing Tang

Segmentation of the aorta is crucial for various medical analyses, such as the diagnosis and treatment of cardiovascular diseases. This work presents mathematical models and methods yielding a semi-automatic segmentation of the aorta from…

Medical Physics · Physics 2025-11-17 Konan A. Allaly , Jozef Urban , Karol Mikula

Diffusion tractography is routinely used to study white matter architecture and brain connectivity in vivo. A key step for successful tractography of neuronal tracts is the correct identification of tract directions in each voxel. Here we…

We present formulations and numerical algorithms for solving diffeomorphic shape matching problems. We formulate shape matching as a variational problem governed by a dynamical system that models the flow of diffeomorphism $f_t \in…

Optimization and Control · Mathematics 2023-07-20 Andreas Mang , Jiwen He , Robert Azencott

Purpose: This study explores the feasibility of using generative machine learning (ML) to translate Optical Coherence Tomography (OCT) images into Optical Coherence Tomography Angiography (OCTA) images, potentially bypassing the need for…

Computer Vision and Pattern Recognition · Computer Science 2024-04-26 Rashadul Hasan Badhon , Atalie Carina Thompson , Jennifer I. Lim , Theodore Leng , Minhaj Nur Alam

The shape of a molecule determines its physicochemical and biological properties. However, it is often underrepresented in standard molecular representation learning approaches. Here, we propose using the Euler Characteristic Transform…

Machine Learning · Computer Science 2025-07-08 Victor Toscano-Duran , Florian Rottach , Bastian Rieck

Tensor time series, which is a time series consisting of tensorial observations, has become ubiquitous. It typically exhibits high dimensionality. One approach for dimension reduction is to use a factor model structure, in a form similar to…

Methodology · Statistics 2024-07-19 Yuefeng Han , Rong Chen , Dan Yang , Cun-Hui Zhang

Accurate planning of transcatheter aortic implantation (TAVI) is important to minimize complications, and it requires anatomic evaluation of the aortic root (AR), commonly done through 3D computed tomography (CT) image analysis. Currently,…

Quantitative Methods · Quantitative Biology 2023-02-13 Simone Saitta , Francesco Sturla , Riccardo Gorla , Omar A. Oliva , Emiliano Votta , Francesco Bedogni , Alberto Redaelli

Intravascular ultrasound and optical coherence tomography are widely available for characterizing coronary stenoses and provide critical vessel parameters to optimize percutaneous intervention. Intravascular polarization-sensitive optical…

Image and Video Processing · Electrical Eng. & Systems 2022-09-15 Mohammad Haft-Javaherian , Martin Villiger , Kenichiro Otsuka , Joost Daemen , Peter Libby , Polina Golland , Brett E. Bouma

The two-point correlation function (2pcf) is the key statistic in structure formation; it measures the clustering of galaxies or other density field tracers. Estimators of the 2pcf, including the standard Landy-Szalay (LS) estimator,…

Cosmology and Nongalactic Astrophysics · Physics 2021-03-31 Kate Storey-Fisher , David W. Hogg

Coronary artery disease (CAD) is one of the most common causes of death in the European Union and the USA. The crucial biomarker in its diagnosis is called Fractional Flow Reserve (FFR) and its in-vivo measurement is obtained via an…

Image and Video Processing · Electrical Eng. & Systems 2024-05-22 Patryk Rygiel

Cardiac MR image segmentation is essential for the morphological and functional analysis of the heart. Inspired by how experienced clinicians assess the cardiac morphology and function across multiple standard views (i.e. long- and…

Image and Video Processing · Electrical Eng. & Systems 2019-12-18 Chen Chen , Carlo Biffi , Giacomo Tarroni , Steffen Petersen , Wenjia Bai , Daniel Rueckert

Accurate 3D representations of cardiac structures allow quantitative analysis of anatomy and function. In this work, we propose a method for reconstructing complete 3D cardiac shapes from segmentations of sparse planes in CT angiography…

Computer Vision and Pattern Recognition · Computer Science 2026-04-07 Gino E. Jansen , Carolina Brás , R. Nils Planken , Mark J. Schuuring , Berto J. Bouma , Ivana Išgum

Optical projection tomography (OPT) is a powerful tool for biomedical studies. It achieves 3D visualization of mesoscopic biological samples with high spatial resolution using conventional tomographic-reconstruction algorithms. However,…

Computer Vision and Pattern Recognition · Computer Science 2023-10-02 Yan Liu , Jonathan Dong , Thanh-An Pham , Francois Marelli , Michael Unser

We propose a fully automated algorithm based on a deep learning framework enabling screening of a coronary computed tomography angiography (CCTA) examination for confident detection of the presence or absence of coronary artery…

Image and Video Processing · Electrical Eng. & Systems 2020-06-09 Sema Candemir , Richard D. White , Mutlu Demirer , Vikash Gupta , Matthew T. Bigelow , Luciano M. Prevedello , Barbaros S. Erdal

Accurately restoring topology is both challenging and crucial in tubular structure extraction tasks, such as blood vessel segmentation and road network extraction. Diverging from traditional approaches based on pixel-level classification,…

Computer Vision and Pattern Recognition · Computer Science 2025-02-18 Zhao Zhang , Ziwei Zhao , Dong Wang , Liwei Wang

Topological Data Analysis (TDA) can be used to detect and characterize holes in an image, such as zero-dimensional holes (connected components) or one-dimensional holes (loops). However, there is currently no widely accepted statistical…

Methodology · Statistics 2025-08-26 Susan Glenn , Jessi Cisewski-Kehe , Jun Zhu , William M Bement

Medical tubular anatomical structures are inherently three-dimensional conduits with lumens, enclosing walls, and complex branching topologies. Accurate reconstruction of their geometry and topology is crucial for applications such as…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Minghui Zhang , Yaoyu Liu , Junyang Wu , Xin You , Hanxiao Zhang , Junjun He , Yun Gu

Automatic detection and classification of Cardiovascular disease (CVD) from Computed Tomography (CT) images play an important part in facilitating better-informed clinical decisions. However, most of the recent deep learning based methods…

Image and Video Processing · Electrical Eng. & Systems 2026-05-07 Ajay Mittal , Raghav Mehta , Omar Todd , Philipp Seeböck , Georg Langs , Ben Glocker

Objective: We aim to provide an algorithm for the detection of myocardial infarction that operates directly on ECG data without any preprocessing and to investigate its decision criteria. Approach: We train an ensemble of fully…

Computers and Society · Computer Science 2019-02-06 Nils Strodthoff , Claas Strodthoff
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