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Most benchmarks for studying surgical interventions focus on a specific challenge instead of leveraging the intrinsic complementarity among different tasks. In this work, we present a new experimental framework towards holistic surgical…

Mediation analysis in causal inference typically concentrates on one binary exposure, using deterministic interventions to split the average treatment effect into direct and indirect effects through a single mediator. Yet, real-world…

Methodology · Statistics 2023-07-07 David B. McCoy , Alan E. Hubbard , Mark van der Laan , Alejandro Schuler

The complexity and variability inherent in high-resolution pathological images present significant challenges in computational pathology. While pathology foundation models leveraging AI have catalyzed transformative advancements, their…

The deep neural network is a research hotspot for histopathological image analysis, which can improve the efficiency and accuracy of diagnosis for pathologists or be used for disease screening. The whole slide pathological image can reach…

Image and Video Processing · Electrical Eng. & Systems 2022-05-09 Tingting Zheng , Weixing chen , Shuqin Li , Hao Quan , Qun Bai , Tianhang Nan , Song Zheng , Xinghua Gao , Yue Zhao , Xiaoyu Cui

Curating high-quality, domain-specific datasets is a major bottleneck for deploying robust vision systems, requiring complex trade-offs between data quality, diversity, and cost when researching vast, unlabeled data lakes. We introduce…

Drug discovery is a long, expensive, and complex process, relying heavily on human medicinal chemists, who can spend years searching the vast space of potential therapies. Recent advances in artificial intelligence for chemistry have sought…

Computation and Language · Computer Science 2025-10-14 Reza Averly , Frazier N. Baker , Ian A. Watson , Xia Ning

Autonomous science agents built on large language models (LLMs) are increasingly used to generate hypotheses, design experiments, and produce reports. However, prior work mainly targets open-ended scientific problems with subjective outputs…

Computation and Language · Computer Science 2026-03-24 Tianshu Zhang , Huan Sun

Recent methods for pathology report generation from whole-slide image (WSI) are capable of producing slide-level diagnostic descriptions but fail to ground fine-grained statements in localized visual evidence. Furthermore, they lack control…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Rundong Wang , Wei Ba , Ying Zhou , Yingtai Li , Bowen Liu , Baizhi Wang , Yuhao Wang , Zhidong Yang , Kun Zhang , Rui Yan , S. Kevin Zhou

Cancer diagnosis, prognosis, and therapeutic response predictions are based on morphological information from histology slides and molecular profiles from genomic data. However, most deep learning-based objective outcome prediction and…

Computer Vision and Pattern Recognition · Computer Science 2020-09-04 Richard J. Chen , Ming Y. Lu , Jingwen Wang , Drew F. K. Williamson , Scott J. Rodig , Neal I. Lindeman , Faisal Mahmood

Identifying potential drug targets using metabolic modeling requires integrating multiple modeling methods and heterogenous biological datasets, which can be challenging without sophisticated tools. We developed COMO, a user-friendly…

Visual AutoRegressive modeling (VAR) suffers from substantial computational cost due to the massive token count involved. Failing to account for the continuous evolution of modeling dynamics, existing VAR token reduction methods face three…

Computer Vision and Pattern Recognition · Computer Science 2026-02-03 Yu Zhang , Jingyi Liu , Feng Liu , Duoqian Miao , Qi Zhang , Kexue Fu , Changwei Wang , Longbing Cao

Evaluating the clinical correctness and reasoning fidelity of automatically generated medical imaging reports remains a critical yet unresolved challenge. Existing evaluation methods often fail to capture the structured diagnostic logic…

Artificial Intelligence · Computer Science 2026-01-26 Suzhong Fu , Jingqi Dong , Xuan Ding , Rui Sun , Yiming Yang , Shuguang Cui , Zhen Li

Alzheimer's disease (AD) presents a complex, multifaceted challenge to patients, caregivers, and the healthcare system, necessitating integrated and dynamic support solutions. While artificial intelligence (AI) offers promising avenues for…

Multiagent Systems · Computer Science 2025-10-13 Adib Bazgir , Amir Habibdoust , Xing Song , Yuwen Zhang

Deep research systems are widely used for multi-step web research, analysis, and cross-source synthesis, yet their evaluation remains challenging. Existing benchmarks often require annotation-intensive task construction, rely on static…

Computation and Language · Computer Science 2026-01-15 Yibo Wang , Lei Wang , Yue Deng , Keming Wu , Yao Xiao , Huanjin Yao , Liwei Kang , Hai Ye , Yongcheng Jing , Lidong Bing

Deep research has revolutionized data analysis, yet data scientists still devote substantial time to manually crafting visualizations, highlighting the need for robust automation from natural language queries. However, current systems…

Artificial Intelligence · Computer Science 2025-10-06 Zichen Chen , Jiefeng Chen , Sercan Ö. Arik , Misha Sra , Tomas Pfister , Jinsung Yoon

Large language model (LLM) agents have demonstrated remarkable capabilities in tool use, reasoning, and code generation, yet single-agent systems exhibit fundamental limitations when confronted with complex research tasks demanding…

Artificial Intelligence · Computer Science 2026-03-17 Aaron Shen , Alfred Shen

The rapid advancement of artificial intelligence, particularly autonomous agentic systems based on Large Language Models (LLMs), presents new opportunities to accelerate drug discovery by improving in-silico modeling and reducing dependence…

PDEs are central to scientific and engineering modeling, yet designing accurate numerical solvers typically requires substantial mathematical expertise and manual tuning. Recent neural network-based approaches improve flexibility but often…

Artificial Intelligence · Computer Science 2026-02-20 Jianda Du , Youran Sun , Haizhao Yang

Scientific Machine Learning (SciML) integrates data-driven inference with physical modeling to solve complex problems in science and engineering. However, the design of SciML architectures, loss formulations, and training strategies remains…

Artificial Intelligence · Computer Science 2026-02-17 Qile Jiang , George Karniadakis

Recent advances in agentic AI have enabled increasingly autonomous workflows, but existing systems still face substantial challenges in achieving reliable deployment in real-world scientific research. In this work, we present a safe,…

Artificial Intelligence · Computer Science 2026-04-16 Qibin Liu , Julia Gonski