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Bridging the gap between theoretical conceptualization and computational implementation is a major bottleneck in Scientific Computing (SciC) and Scientific Machine Learning (SciML). We introduce ATHENA (Agentic Team for Hierarchical…

Machine Learning · Computer Science 2026-05-11 Juan Diego Toscano , Daniel T. Chen , George Em Karniadakis

Histopathology remains the gold standard for cancer diagnosis because it provides detailed cellular-level assessment of tissue morphology. However, manual histopathological examination is time-consuming, labour-intensive, and subject to…

Computer Vision and Pattern Recognition · Computer Science 2026-03-13 Ravi Mosalpuri , Mohammed Abdelsamea , Ahmed Karam Eldaly

The rapid growth of biomedical data, tools, and literature has created a fragmented research landscape that outpaces human expertise. While AI agents offer a solution, they typically rely on static, manually curated toolsets, limiting their…

Artificial Intelligence · Computer Science 2025-07-04 Ruofan Jin , Zaixi Zhang , Mengdi Wang , Le Cong

Automated pathology image analysis is central to clinical diagnosis, but clinicians still ask which slide features drive a model's decision and why. Vision-language models can produce natural language explanations, but these are often…

Artificial Intelligence · Computer Science 2026-01-06 Kewen Cao , Jianxu Chen , Yongbing Zhang , Ye Zhang , Hongxiao Wang

Computational pathology has advanced rapidly in recent years, driven by domain-specific image encoders and growing interest in using vision-language models to answer natural-language questions about diseases. Yet, the core problem behind…

Computer Vision and Pattern Recognition · Computer Science 2026-03-31 Wentao Huang , Weimin Lyu , Peiliang Lou , Qingqiao Hu , Xiaoling Hu , Shahira Abousamra , Wenchao Han , Ruifeng Guo , Jiawei Zhou , Chao Chen , Chen Wang

The current landscape of AI for Science (AI4S) is predominantly anchored in large-scale textual corpora, where generative AI systems excel at hypothesis generation, literature search, and multi-modal reasoning. However, a critical…

We introduce DeepSearchQA, a 900-prompt benchmark for evaluating agents on difficult multi-step information-seeking tasks across 17 different fields. Unlike traditional benchmarks that target single answer retrieval or broad-spectrum…

Digital pathology has emerged as a transformative approach to tissue analysis, offering unprecedented opportunities for objective, quantitative assessment of histopathological features. However, the complexity of implementing artificial…

Quantitative Methods · Quantitative Biology 2025-09-17 Noor Shaker , Mohamed AbouZleikha , Nuha Shaker

Pathology is experiencing rapid digital transformation driven by whole-slide imaging and artificial intelligence (AI). While deep learning-based computational pathology has achieved notable success, traditional models primarily focus on…

ANOVA Simultaneous Component Analysis (ASCA) is the current state-of-theart chemometric tool for analyzing and interpreting high-dimensional experimental data from a Design of Experiment (DoE). Being a multivariate extension of the ANOVA,…

Methodology · Statistics 2026-05-20 José Camacho , Jokin Ezenarro , Daniel Schorn-García , Johan A. Westerhuis

The automation of scientific research workflows has emerged as a transformative frontier in artificial intelligence, yet existing autonomous research agents remain largely domain-agnostic, lacking the specialized reasoning, method…

Artificial Intelligence · Computer Science 2026-05-05 Bing Zhou , Xiao Huang , Huan Ning , Qiusheng Wu , Diya Li , Ziyi Zhang

AI tools can greatly enhance the analysis of organoid microscopy images, from detection and segmentation to feature extraction and classification. However, their limited accessibility to biologists without programming experience remains a…

Computer Vision and Pattern Recognition · Computer Science 2025-11-04 Mikhail Konov , Lion J. Gleiter , Khoa Co , Monica Yabal , Tingying Peng

Histopathology nuclei segmentation is crucial for quantitative tissue analysis and cancer diagnosis. Although existing segmentation methods have achieved strong performance, they are often computationally heavy and show limited…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Muhammad Hassan Maqsood , Yanming Zhu , Alfred Lam , Getamesay Dagnaw , Xuefei Yin , Alan Wee-Chung Liew

Semantic segmentation is a crucial task in biomedical image processing, which recent breakthroughs in deep learning have allowed to improve. However, deep learning methods in general are not yet widely used in practice since they require…

Computer Vision and Pattern Recognition · Computer Science 2019-07-12 Melanie Lubrano di Scandalea , Christian S. Perone , Mathieu Boudreau , Julien Cohen-Adad

Agentic AI is rapidly advancing in healthcare and biomedical research. However, in medical image analysis, their performance and adoption remain limited due to the lack of a robust ecosystem, insufficient toolsets, and the absence of…

Computer Vision and Pattern Recognition · Computer Science 2025-09-25 Songhao Li , Jonathan Xu , Tiancheng Bao , Yuxuan Liu , Yuchen Liu , Yihang Liu , Lilin Wang , Wenhui Lei , Sheng Wang , Yinuo Xu , Yan Cui , Jialu Yao , Shunsuke Koga , Zhi Huang

Multimodal agentic pipelines are transforming human-computer interaction by enabling efficient and accessible automation of complex, real-world tasks. However, recent efforts have focused on short-horizon or general-purpose applications…

Computer Vision and Pattern Recognition · Computer Science 2026-03-26 Akash Ghosh , Tajamul Ashraf , Rishu Kumar Singh , Numan Saeed , Sriparna Saha , Xiuying Chen , Salman Khan

Computational pathology (CoPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CoPath that are annotated with extensive histological…

Colorectal diseases, including inflammatory conditions and neoplasms, require quick, accurate care to be effectively treated. Traditional diagnostic pipelines require extensive preparation and rely on separate, individual evaluations on…

Computer Vision and Pattern Recognition · Computer Science 2025-09-09 Krithik Ramesh , Ritvik Koneru

Computational notebooks, such as Jupyter Notebook, have become data scientists' de facto programming environments. Many visualization researchers and practitioners have developed interactive visualization tools that support notebooks, yet…

Human-Computer Interaction · Computer Science 2024-04-01 Zijie J. Wang , David Munechika , Seongmin Lee , Duen Horng Chau

Histopathological images contain abundant phenotypic information and pathological patterns, which are the gold standards for disease diagnosis and essential for the prediction of patient prognosis and treatment outcome. In recent years,…

Computer Vision and Pattern Recognition · Computer Science 2022-10-26 Linhao Qu , Siyu Liu , Xiaoyu Liu , Manning Wang , Zhijian Song