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Neuropsychiatric disorders, such as Alzheimer's disease (AD), depression, and autism spectrum disorder (ASD), are characterized by linguistic and acoustic abnormalities, offering potential biomarkers for early detection. Despite the promise…

Computation and Language · Computer Science 2025-12-25 Zhongren Dong , Haotian Guo , Weixiang Xu , Huan Zhao , Zixing Zhang

We propose a novel deep neural network architecture to integrate imaging and genetics data, as guided by diagnosis, that provides interpretable biomarkers. Our model consists of an encoder, a decoder and a classifier. The encoder learns a…

Capturing subtle speech disruptions across the psychosis spectrum is challenging because of the inherent variability in speech patterns. This variability reflects individual differences and the fluctuating nature of symptoms in both…

Schizophrenia (SZ) is a complex mental disorder that necessitates accurate and timely diagnosis for effective treatment. Traditional methods for SZ classification often struggle to capture transient EEG features and face high computational…

Signal Processing · Electrical Eng. & Systems 2024-07-26 Umesh Kumar Naik M , Shaik Rafi Ahamed

Natural language processing tools are used to automatically detect disturbances in transcribed speech of schizophrenia inpatients who speak Hebrew. We measure topic mutation over time and show that controls maintain more cohesive speech…

Computation and Language · Computer Science 2019-04-18 Kfir Bar , Vered Zilberstein , Ido Ziv , Heli Baram , Nachum Dershowitz , Samuel Itzikowitz , Eiran Vadim Harel

Speech holds promise as a cost-effective and non-invasive biomarker for neurological conditions such as Parkinson's disease (PD). While deep learning systems trained on raw audio can find subtle signals not available from hand-crafted…

Audio and Speech Processing · Electrical Eng. & Systems 2025-07-24 Peter Plantinga , Jen-Kai Chen , Roozbeh Sattari , Mirco Ravanelli , Denise Klein

Schizophrenia (SZ) is a severe brain disorder marked by diverse cognitive impairments, abnormalities in brain structure, function, and genetic factors. Its complex symptoms and overlap with other psychiatric conditions challenge traditional…

Computer Vision and Pattern Recognition · Computer Science 2024-07-30 Nagur Shareef Shaik , Teja Krishna Cherukuri , Vince D. Calhoun , Dong Hye Ye

Patients with schizophrenia often display impairments in the expression of emotion and speech and those are observed in their facial behaviour. Automatic analysis of patients' facial expressions that is aimed at estimating symptoms of…

Computer Vision and Pattern Recognition · Computer Science 2018-08-09 Mina Bishay , Petar Palasek , Stefan Priebe , Ioannis Patras

Background: An early diagnosis together with an accurate disease progression monitoring of multiple sclerosis is an important component of successful disease management. Prior studies have established that multiple sclerosis is correlated…

Audio and Speech Processing · Electrical Eng. & Systems 2021-09-28 Emil Svoboda , Tomáš Bořil , Jan Rusz , Tereza Tykalová , Dana Horáková , Charles R. G. Guttman , Krastan B. Blagoev , Hiroto Hatabu , Vlad I. Valtchinov

Schizophrenia is a chronic neuropsychiatric disorder that causes distinct structural alterations within the brain. We hypothesize that deep learning applied to a structural neuroimaging dataset could detect disease-related alteration and…

Image and Video Processing · Electrical Eng. & Systems 2022-07-08 Junhao Zhang , Vishwanatha M. Rao , Ye Tian , Yanting Yang , Nicolas Acosta , Zihan Wan , Pin-Yu Lee , Chloe Zhang , Lawrence S. Kegeles , Scott A. Small , Jia Guo

Dysarthria is a speech disorder characterized by impaired intelligibility and reduced communicative effectiveness. Automatic dysarthria assessment provides a scalable, cost-effective approach for supporting the diagnosis and treatment of…

Audio and Speech Processing · Electrical Eng. & Systems 2025-11-05 Kaimeng Jia , Minzhu Tu , Zengrui Jin , Siyin Wang , Chao Zhang

Schizophrenia is one of the most disabling mental health conditions to live with. Approximately one percent of the population has schizophrenia which makes it fairly common, and it affects many people and their families. Patients with…

Computation and Language · Computer Science 2022-01-26 Amal Alqahtani , Efsun Sarioglu Kay , Sardar Hamidian , Michael Compton , Mona Diab

This paper presents a novel multimodal framework to distinguish between different symptom classes of subjects in the schizophrenia spectrum and healthy controls using audio, video, and text modalities. We implemented Convolution Neural…

Audio and Speech Processing · Electrical Eng. & Systems 2024-09-17 Gowtham Premananth , Yashish M. Siriwardena , Philip Resnik , Sonia Bansal , Deanna L. Kelly , Carol Espy-Wilson

Alzheimers disease (AD) is a progressive disorder that affects cognitive brain functions and starts many years before its clinical manifestations. A biomarker that provides a quantitative measure of changes in the brain due to AD in the…

Neurons and Cognition · Quantitative Biology 2022-05-19 Ali H. Al-Nuaimi , Emmanuel Jammeh , Lingfen Sun , Emmanuel Ifeachor

In the field of neuroscience, Brain activity analysis is always considered as an important area. Schizophrenia(Sz) is a brain disorder that severely affects the thinking, behaviour, and feelings of people all around the world.…

Signal Processing · Electrical Eng. & Systems 2021-11-23 Geetanjali Sharma , Amit M. Joshi

Research in machine learning for autism spectrum disorder (ASD) classification bears the promise to improve clinical diagnoses. However, recent studies in clinical imaging have shown the limited generalization of biomarkers across and…

Machine Learning · Computer Science 2022-09-23 Christian Gerloff , Kerstin Konrad , Jana Kruppa , Martin Schulte-Rüther , Vanessa Reindl

Background: Alzheimer's disease and related dementias (ADRD) are progressive neurodegenerative conditions where early detection is vital for timely intervention and care. Spontaneous speech contains rich acoustic and linguistic markers that…

Computation and Language · Computer Science 2025-06-16 Jingyu Li , Lingchao Mao , Hairong Wang , Zhendong Wang , Xi Mao , Xuelei Sherry Ni

Large-scale end-to-end models such as Whisper have shown strong performance on diverse speech tasks, but their internal behavior on pathological speech remains poorly understood. Understanding how dysarthric speech is represented across…

Audio and Speech Processing · Electrical Eng. & Systems 2025-10-07 Zhengjun Yue , Devendra Kayande , Zoran Cvetkovic , Erfan Loweimi

Dementia encompasses a group of syndromes that impair cognitive functions such as memory, reasoning, and the ability to perform daily activities. As populations globally age, over 10 million new dementia diagnoses are reported annually.…

Audio and Speech Processing · Electrical Eng. & Systems 2026-04-24 Marko Niemelä , Mikaela von Bonsdorff , Sami Äyrämö , Tommi Kärkkäinen

Autism Spectrum Disorder (ASD) is a multi-factorial neurodevelopmental disorder, whose causes are still poorly understood. Effective therapies to reduce all the heterogeneous symptoms of the disorder do not exists yet, but behavioural…

Neurons and Cognition · Quantitative Biology 2025-06-02 Elisa Ferrari , Alessandra Retico , Alessandro Cellerino , Davide Bacciu