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In medical applications, deep learning methods are built to automate diagnostic tasks. However, a clinically relevant question that practitioners usually face, is how to predict the future trajectory of a disease (prognosis). Current…

Machine Learning · Computer Science 2021-12-08 Huy Hoang Nguyen , Simo Saarakkala , Matthew B. Blaschko , Aleksei Tiulpin

Incurable diseases continue to pose major challenges to global healthcare systems, with their prevalence shaped by lifestyle, economic, social, and genetic factors. Among these, kidney disease remains a critical global health issue,…

Image and Video Processing · Electrical Eng. & Systems 2025-07-04 Yassine Habchi , Hamza Kheddar , Yassine Himeur , Mohamed Chahine Ghanem , Abdelkrim Boukabou , Shadi Atalla , Wathiq Mansoor , Hussain Al-Ahmad

Machine learning models for chronic kidney disease (CKD) risk prediction often post strong discrimination scores on internal test sets. Calibration and uncertainty quantification get far less attention, leaving clinicians without reliable…

Machine Learning · Computer Science 2026-05-22 Michael O. Eniolade

Chronic diseases, such as cardiovascular disease, diabetes, chronic kidney disease, and thyroid disorders, are the leading causes of premature mortality worldwide. Early detection and intervention are crucial for improving patient outcomes,…

Machine Learning · Computer Science 2025-11-04 Houda Belhad , Asmae Bourbia , Salma Boughanja

Background: Hypertensive kidney disease (HKD) patients in intensive care units (ICUs) face high short-term mortality, but tailored risk prediction tools are lacking. Early identification of high-risk individuals is crucial for clinical…

Machine Learning · Computer Science 2025-07-28 Yong Si , Junyi Fan , Li Sun , Shuheng Chen , Minoo Ahmadi , Elham Pishgar , Kamiar Alaei , Greg Placencia , Maryam Pishgar

Electronic health records represent a holistic overview of patients' trajectories. Their increasing availability has fueled new hopes to leverage them and develop accurate risk prediction models for a wide range of diseases. Given the…

In this paper we study the problem of predicting clinical diagnoses from textual Electronic Health Records (EHR) data. We show the importance of this problem in medical community and present comprehensive historical review of the problem…

Computation and Language · Computer Science 2020-09-29 Pavel Blinov , Manvel Avetisian , Vladimir Kokh , Dmitry Umerenkov , Alexander Tuzhilin

We developed deep learning models for predicting Total Knee Replacement (TKR) need within various time horizons in knee osteoarthritis patients, with a novel capability: the models can perform TKR prediction using a single scan, and…

Image and Video Processing · Electrical Eng. & Systems 2025-03-31 Haresh Rengaraj Rajamohan , Richard Kijowski , Kyunghyun Cho , Cem M. Deniz

Acute Kidney Injury (AKI), a sudden decline in kidney function, is associated with increased mortality, morbidity, length of stay, and hospital cost. Since AKI is sometimes preventable, there is great interest in prediction. Most existing…

Machine Learning · Computer Science 2019-03-06 Samuel J. Weisenthal , Caroline Quill , Samir Farooq , Henry Kautz , Martin S. Zand

Acute kidney injury (AKI) commonly occurs in hospitalized patients and can lead to serious medical complications. In order to optimally predict AKI before it develops at any time during a hospital stay, we present a novel framework in which…

Quantitative Methods · Quantitative Biology 2019-02-28 Rohit J. Kate , Noah Pearce , Debesh Mazumdar , Vani Nilakantan

Cardiovascular disease and chronic kidney disease are major complications of diabetes, leading to high morbidity and mortality. Early detection of these conditions is critical, yet traditional diagnostic markers often lack sensitivity in…

Other Quantitative Biology · Quantitative Biology 2025-10-20 Syed Ibad Hasnain

We propose machine learning algorithms to automatically detect and predict clopidogrel treatment failure using longitudinal structured electronic health records (EHR). By drawing analogies between natural language and structured EHR, we…

Machine Learning · Computer Science 2023-10-16 Samuel Kim , In Gu Sean Lee , Mijeong Irene Ban , Jane Chiang

Objectives: We aim to quantify longitudinal acute kidney injury (AKI) trajectories and to describe transitions through progressing and recovery states and outcomes among hospitalized patients using multistate models. Methods: In this large,…

Quantitative Methods · Quantitative Biology 2023-03-13 Esra Adiyeke , Yuanfang Ren , Ziyuan Guan , Matthew M. Ruppert , Parisa Rashidi , Azra Bihorac , Tezcan Ozrazgat-Baslanti

Longitudinal MRI analysis is crucial for predicting disease outcomes, particularly in chronic conditions like hepatocellular carcinoma (HCC), where early detection can significantly influence treatment strategies and patient prognosis. Yet,…

Computer Vision and Pattern Recognition · Computer Science 2025-01-23 Jakob Nolte , Maureen M. J. Guichelaar , Donald E. Bouman , Stephanie M. van den Berg , Maryam Amir Haeri

Clinical risk prediction using electronic health records (EHRs) is vital to facilitate timely interventions and clinical decision support. However, modeling heterogeneous and irregular temporal EHR data presents significant challenges. We…

Machine Learning · Computer Science 2025-11-04 Kun-Wei Lin , Yu-Chen Kuo , Hsin-Yao Wang , Yi-Ju Tseng

Background: Hip replacement procedures improve patient lives by relieving pain and restoring mobility. Predicting hip replacement in advance could reduce pain by enabling timely interventions, prioritising individuals for surgery or…

Machine Learning · Computer Science 2024-09-11 Zoe Hancox , Sarah R. Kingsbury , Andrew Clegg , Philip G. Conaghan , Samuel D. Relton

This study proposed a hybrid model of a convolutional neural network (CNN) and a Transformer to predict and diagnose heart disease. Based on CNN's strength in detecting local features and the Transformer's high capacity in sensing global…

Machine Learning · Computer Science 2025-03-05 Ran Hao , Yanlin Xiang , Junliang Du , Qingyuan He , Jiacheng Hu , Ting Xu

Deep neural networks are often applied to medical images to automate the problem of medical diagnosis. However, a more clinically relevant question that practitioners usually face is how to predict the future trajectory of a disease.…

Image and Video Processing · Electrical Eng. & Systems 2023-09-20 Huy Hoang Nguyen , Matthew B. Blaschko , Simo Saarakkala , Aleksei Tiulpin

In this study, we introduce ExBEHRT, an extended version of BEHRT (BERT applied to electronic health records), and apply different algorithms to interpret its results. While BEHRT considers only diagnoses and patient age, we extend the…

Machine Learning · Computer Science 2023-08-14 Maurice Rupp , Oriane Peter , Thirupathi Pattipaka

With recent achievements in tasks requiring context awareness, foundation models have been adopted to treat large-scale data from electronic health record (EHR) systems. However, previous clinical recommender systems based on foundation…

Artificial Intelligence · Computer Science 2023-02-02 Seunghyun Lee , Da Young Lee , Sujeong Im , Nan Hee Kim , Sung-Min Park