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We introduce a single-frame diffractive imaging method called randomized probe imaging (RPI). In RPI, a sample is illuminated by a structured probe field containing speckles smaller than the sample's typical feature size. Quantitative…

With applications ranging from metabolomics to histopathology, quantitative phase microscopy (QPM) is a powerful label-free imaging modality. Despite significant advances in fast multiplexed imaging sensors and deep-learning-based inverse…

Quantitative phase imaging (QPI) has been widely applied in characterizing cells and tissues. Spatial light interference microscopy (SLIM) is a highly sensitive QPI method, due to its partially coherent illumination and common path…

Image and Video Processing · Electrical Eng. & Systems 2024-06-12 Yuheng Jiao , Yuchen R. He , Mikhail E. Kandel , Xiaojun Liu , Wenlong Lu , Gabriel Popescu

We present an entanglement-based quantitative phase gradient microscopy technique that employs principles from quantum ghost imaging and ghost diffraction. In this method, a transparent sample is illuminated by both photons of an entangled…

Quantum Physics · Physics 2026-03-09 Yingwen Zhang , Paul-Antoine Moreau , Duncan England , Ebrahim Karimi , Benjamin Sussman

We present Quanta Diffusion (QuDi), a powerful generative video reconstruction method for single-photon imaging. QuDi is an algorithm supporting the latest Quanta Image Sensors (QIS) and Single Photon Avalanche Diodes (SPADs) for extremely…

Image and Video Processing · Electrical Eng. & Systems 2025-10-14 Prateek Chennuri , Dongdong Fu , Stanley H. Chan

Quantitative phase microscopy (QPM), a technique combining phase imaging and microscopy, enables visualization of the 3D topography in reflective samples, as well as the inner structure or refractive index distribution of transparent and…

Optics · Physics 2025-01-17 Vicente Mico , Juanjuan Zheng , Javier Garcia , Zeev Zalevsky , Peng Gao

Due to its specificity, fluorescence microscopy (FM) has become a quintessential imaging tool in cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit FM's utility. Recently, it has been shown that…

A major hurdle in Quantum Image Processing (QIMP) is efficiently transferring classical, high-dimensional image data into quantum states. Current methods face trade-offs: amplitude encoding (FRQI) is computationally expensive in gate…

Multi-spectral quantitative phase imaging (QPI) is an emerging imaging modality for wavelength dependent studies of several biological and industrial specimens. Simultaneous multi-spectral QPI is generally performed with color CCD cameras.…

Instrumentation and Detectors · Physics 2019-02-20 Azeem Ahmad , Anand Kumar , Vishesh Dubey , Ankit Butola , Balpreet Singh Ahluwalia , Dalip Singh Mehta

We demonstrate a single-arm optical platform for phase-retrieval-free, quantitative dynamic phase mapping of continuous transparent media via field-correlation ghost imaging. By modeling the medium as a dynamic pure-phase object, we…

Optics · Physics 2026-03-24 Chaoran Wang , Jinquan Qi , Shuang Liu , Xingzhao Jiang , Shensheng Han

Fourier ptychographic microscopy (FPM) is a recently developed imaging modality that uses angularly varying illumination to extend a system performance beyond the limit defined by its optical elements. The FPM technique applies a novel…

Optics · Physics 2014-05-02 Xiaoze Ou , Roarke Horstmeyer , Changhuei Yang , Guoan Zheng

White light phase-shifting interference microscopy (WL-PSIM) is a prominent technique for high-resolution quantitative phase imaging (QPI) of industrial and biological specimens. However, multiple interferograms with accurate phase-shifts…

Image and Video Processing · Electrical Eng. & Systems 2021-05-04 Sunil Bhatt , Ankit Butola , Sheetal Raosaheb Kanade , Anand Kumar , Dalip Singh Mehta

Measuring the average refractive index (RI) of spherical objects, such as suspended cells, in quantitative phase imaging (QPI) requires a decoupling of RI and size from the QPI data. This has been commonly achieved by determining the…

Quantitative Methods · Quantitative Biology 2018-04-27 Paul Müller , Mirjam Schürmann , Salvatore Girardo , Gheorghe Cojoc , Jochen Guck

Coded wavefront sensing (Coded-WFS) is a snapshot quantitative phase imaging (QPI) technique that has been shown to successfully leverage the memory effect to retrieve the phase of biological specimens. In this paper, we perform QPI on…

Quantitative phase imaging (QPI) is a valuable label-free modality that has gained significant interest due to its wide potentials, from basic biology to clinical applications. Most existing QPI systems measure microscopic objects via…

Optics · Physics 2021-12-22 Chenfei Hu , Mikhail E. Kandel , Young Jae Lee , Gabriel Popescu

Purpose: Quantitative phase imaging (QPI) is a label-free technique that provides high-contrast images of tissues and cells without the use of chemicals or dyes. Accurate semantic segmentation of cells in QPI is essential for various…

Image and Video Processing · Electrical Eng. & Systems 2024-05-13 Zhuchen Shao , Mark A. Anastasio , Hua Li

Quadriwave lateral shearing interferometry (QLSI) is a quantitative phase imaging technique based on the use of a diffraction grating placed in front of a camera. This grating creates a wire-mesh-like image, called an interferogram, that is…

Optics · Physics 2022-03-15 Guillaume Baffou

Quantum phase imaging enables the analysis of transparent samples with thickness and refractive index variations in scenarios requiring precise measurements under low-light conditions. Here, we present a compact quantum phase-gradient…

The structural complexity and instability of many interference phase microscopy methods are the major obstacles toward high-precision phase measurement. In this vein, improving more efficient configurations as well as proposing new methods…

Optics · Physics 2020-01-08 Samira Ebrahimi , Masoomeh Dashtdar

Optical microscopy has been employed to derive salient characteristics of an object in various fields, including cell biology, flow cytometry, biopsy, and neuroscience. In particular, measuring the phase of light scattered from an object…

Optics · Physics 2025-03-18 Jeonghun Oh , Herve Hugonnet , Weisun Park , YongKeun Park